Unusual Ovarian Malignancies in Ascitic Fluid

Murugan, Paari; Siddaraju, Neelaiah; Sridhar, Epaari; Soundararaghavan, Jayanthi; Habeebullah, Syed

doi:10.1159/000325187

Cited by 13 publications

(17 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many cells have vacuolated cytoplasm and eccentric placed hyperchromatic nuclei with marked pleomorphism and inconspicuous nucleoli. [71] The cytomorphologic features of yolk sac tumors in fluid cytology overlap with adenocarcinoma and the use of a cell block for a definitive diagnosis is recommended. [72] Immunostains in challenging cases is usually necessary.…”

Section: Introductionmentioning

confidence: 99%

Abdominopelvic washings: A comprehensive review

Rodrı́guez¹,

Khalbuss²,

Austin³

et al. 2013

CytoJournal

View full text Add to dashboard Cite

Intraperitoneal spread may occur with gynecological epithelial neoplasms, as well as with non-gynecological malignancies, which may result in serosal involvement with or without concomitant effusion. Therefore, washings in patients with abdominopelvic tumors represent important specimens for cytologic examination. They are primarily utilized for staging ovarian cancers, although their role has decreased in staging of endometrial and cervical carcinoma. Abdominopelvic washings can be positive in a variety of pathologic conditions, including benign conditions, borderline neoplastic tumors, locally invasive tumors, or distant metastases. In a subset of cases, washings can be diagnostically challenging due to the presence of co-existing benign cells (e.g., mesothelial hyperplasia, endosalpingiosis, or endometriosis), lesions in which there is only minimal atypia (e.g., serous borderline tumors) or scant atypical cells, and the rarity of specific tumor types (e.g., mesothelioma). Ancillary studies including immunocytochemistry and fluorescence in situ hybridization may be required in difficult cases to resolve the diagnosis. This article provides a comprehensive and contemporary review of abdominopelvic washings in the evaluation of gynecologic and non-gynecologic tumors, including primary peritoneal and mesothelial entities.

show abstract

Section: Introductionmentioning

confidence: 99%

Abdominopelvic washings: A comprehensive review

Rodrı́guez¹,

Khalbuss²,

Austin³

et al. 2013

CytoJournal

View full text Add to dashboard Cite

show abstract

“…92,[126][127][128]130 The borders of the three-dimensional groups are smooth, and cells will be overlapping. 92,[126][127][128]130 Intra-and extracellular periodic acid Schiff positive hyaline globules, and a hyaline basement membrane material may be observed, but overt Schiller-Duval bodies are usually not identified in cytology samples. 92,[126][127][128]130 Intra-and extracellular periodic acid Schiff positive hyaline globules, and a hyaline basement membrane material may be observed, but overt Schiller-Duval bodies are usually not identified in cytology samples.…”

Section: Yolk Sac Tumorsmentioning

confidence: 99%

“…Adult granulosa cell tumors are often large, cystic, and hemorrhagic tumors, which can present with tumor rupture and positive APW. [130][131][132] Rare microfollicular structures with amorphous material, characteristic of the pathognomonic Call-Exner bodies, are rarely seen in fluids. [130][131][132][133] The tumor cells show round to oval, often eccentrically placed hyperchromatic nuclei with nuclear grooves and granular chromatin (Fig.…”

Section: Granulosa Cell Tumormentioning

confidence: 99%

“…[130][131][132][133] The tumor cells show round to oval, often eccentrically placed hyperchromatic nuclei with nuclear grooves and granular chromatin (Fig. 130,[132][133][134] The cytoplasmic borders of [130][131][132] Rare microfollicular structures with amorphous material, characteristic of the pathognomonic Call-Exner bodies, are rarely seen in fluids.…”

Section: Granulosa Cell Tumormentioning

confidence: 99%

“…44, No 12juvenile granulosa cells tumors are well defined 130. (B) Cell block from the same patient demonstrating anucleate and nucleated squamous cells (H&E stain, 403).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Abdominopelvic washings in gynecologic pathology: A comprehensive review

Schulte

Lastra

2016

Diagnostic Cytopathology

View full text Add to dashboard Cite

Abdominopelvic washings (APW) performed during gynecologic surgeries have become a common specimen evaluated by cytopathologists. Their role in staging of female genital tract tumors has changed significantly since they were first described, and continue to evolve. The ability of these washings to detect microscopic disease, even in the absence of gross disease, warrants the critical role that these washings play in the staging of certain female gynecologic tract tumors, allowing for optimal staging and subsequent treatment of the patient. Irrespective of the underlying pathology, the gamut of cytomorphologic findings that may be observed in APW is extensive, and ranges from benign lesions that may act as mimickers of malignancy, to both common and rare malignancies. This review discusses the changing role of APW in the staging of gynecologic tumors, and highlights the salient cytomorphologic features of these lesions, with emphasis in their correct identification, including cautionary notes to avoid over or misinterpretation. Diagn. Cytopathol. 2016;44:1039-1057. © 2016 Wiley Periodicals, Inc.

show abstract

Adult granulosa cell tumor presenting as metastases to the pleural and peritoneal cavity

Gupta

Rajwanshi

Dey

et al. 2011

Diagnostic Cytopathology

View full text Add to dashboard Cite

Ovarian tumors of sex-cord stromal derivation rarely exfoliate malignant cells in serous effusions. Adult granulosa cell tumor (AGCT) often presents as a stage I disease and association with ascites is about 10%. AGCT is rarely known to exfoliate tumor cells in the ascitic fluid. Exfoliation of malignant cells in the pleural fluid is rarer and has not been described previously in literature to the best of our knowledge. We report a case of AGCT presenting as stage IV disease with exfoliation of malignant cells in the pleural and ascitic fluid with exudative effusions. We wish to emphasize on cytomorphologic features of AGCT to differentiate the same from malignant epithelial tumors. A precise diagnosis in such a case may be possible on serous body fluid cytology with a combined clinical and cytopathologic approach.

show abstract

Unusual Ovarian Malignancies in Ascitic Fluid

Cited by 13 publications

References 9 publications

Abdominopelvic washings: A comprehensive review

Abdominopelvic washings: A comprehensive review

Abdominopelvic washings in gynecologic pathology: A comprehensive review

Adult granulosa cell tumor presenting as metastases to the pleural and peritoneal cavity

Contact Info

Product

Resources

About