Unusual pathological fracture of the clavicle revealing primary hyperparathyroidism: a case report

Benameur, Yassir; Guerrouj, H.; Ghfir, I.; Aouad, Nouzha Ben Rais

doi:10.1186/s13256-017-1509-7

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…None of our patients developed severe complications. However, three Grade 5 toxicities due to bleeding, one from aorto-esophageal fistula, and one from perforation of gastric ulcer have been reported [ 19 , 22 , 29 ]. The former 4 patients had a central tumor, while the latter one patient had a peripheral tumor.…”

Section: Discussionmentioning

confidence: 99%

Repeat stereotactic body radiotherapy (SBRT) for local recurrence of non-small cell lung cancer and lung metastasis after first SBRT

et al. 2018

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BackgroundThis study evaluated the safety and efficacy of repeat SBRT for local recurrence of stage I non-small-cell lung cancer (NSCLC) and solitary lung metastasis.MethodsThirty-one patients with in-field local relapse of NSCLC (n = 23) or lung metastasis (n = 8) underwent repeat SBRT. All patients had grade 2 or lower radiation pneumonitis after the first SBRT. Local recurrence was diagnosed with CT and FDG-PET in 17 patients and by biopsy in 14. The median interval between the first and second SBRT was 18 months (range, 4–80). The first SBRT dose was mainly 48–52 Gy in 4 fractions (n = 25) according to the institutional protocols. Second SBRT doses were determined based on the tumor size and distance to organs at risk, and were mostly 48–52 Gy in 4 fractions (n = 13) or 60 Gy in 8 fractions (n = 13).ResultsAt 3 years, overall survival and local control rates were 36 and 53%, respectively, for all 31 patients. Four patients showed no further recurrence for > 5 years (63–111 months) after the second SBRT. Radiation pneumonitis after the second SBRT was grade 2 in 4 patients, and no grade 3 pneumonitis was observed.ConclusionRepeat SBRT was safe. Local control and survival rates were higher than expected. SBRT should be an important treatment option for local recurrence of NSCLC or lung metastasis after previous local SBRT.Trial registrationThis retrospective study was approved by the ethics committee of our institution (September, 2017; approval number: 27–10).

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Section: Discussionmentioning

confidence: 99%

Repeat stereotactic body radiotherapy (SBRT) for local recurrence of non-small cell lung cancer and lung metastasis after first SBRT

et al. 2018

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“…Thirteen case reports presented patients with a nonmalignant cause of superscans. In addition to kidney disease ( n = 2) (Campeau et al, 1987; Ohashi et al, 1991), hyperparathyroidism ( n = 3) (Benameur et al, 2017; Gupta et al, 2020; Zanglis et al, 2006) and hyperthyreose ( n = 1) (Koizumi & Matsumoto, 1998), rare diseases such as Castleman disease (Washington et al, 2010), osteopetrosis (Kim et al, 2001) and systemic mastocytosis presented as superscans (Khoury et al, 2003; Pinto‐Lopes et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Frequency of superscan on bone scintigraphy: A systematic review

Kovacsne

Kozon

Bentestuen

2023

Clin Physio Funct Imaging

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Introduction Bone scintigraphy (BS) is an important tool for detecting bone metastasis. BS with diffuse increased skeletal radioisotope uptake with absent or faint urinary tract and soft tissue activity is defined as a superscan. In this review, we investigate the different etiologies causing superscan and the reported frequency of superscan among different disease entities. Materials and Methods The search terms were ‘bone’ AND ‘superscan’ OR ‘superscan’ in the PubMed database from 1980 to November 2020. Eligibility criteria included the following: Peer‐reviewed studies containing original data using 99mTc‐phosphate‐analogue BS reporting a superscan pattern. Unretrievable papers, imaging modalities other than BS or with insufficient information to assess the aetiology were excluded. The abstracts of every paper and full texts of potentially eligible papers were assessed independently by three observers. Results Sixty‐seven papers were included (48 case reports and 19 cohort studies). Studies conducted in patients with osteomalacia or skeletal fluorosis revealed superscan in all patients. Other benign causes of superscan were hyperparathyroidism and kidney disease. Among papers with malignant cause, prostate cancer was the most common cause, followed by gastric cancer. The frequency of superscans ranged from 1.3% in a cohort of mixed cancer types up to 2.6% in patients with gastric cancer and up to 23% in a cohort of prostate cancer patients. Conclusion Superscan is most frequently seen in prostate cancer, but numerous other cancers and metabolic bone diseases can cause superscan, which should be kept in mind when encountering an unexpected superscan on BS.

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Primary Hyperparathyroidism in the Common Orthopaedic Practice

Sferopoulos¹

2021

TOORTHJ

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An extensive review of the publications on primary hyperparathyroidism (pHPT) is presented in this report. It has strongly been emphasized in the literature that patients with pHPT may present either with the classical symptomatology or with asymptomatic disease, emerged due to biochemical screening. The clinical and epidemiological presentation of pHPT in western countries has changed profoundly during the past few decades, and bone disease is nowadays a distinct rarity. The introduction of serum calcium screening for osteoporosis and the technological advances in the laboratory assessment of parathyroid hormone have played important roles in early diagnosis. Subsequently, the disease is increasingly being detected as asymptomatic hypercalcaemia without guiding signs or symptoms. A third type of disease, the normocalcaemic variant, has been recently described in the literature. However, the potential diagnosis of pHPT should always be on the orthopaedics’ list of differential diagnoses in female or elderly patients with vertebral fractures and nephrolithiasis, either symptomatic or asymptomatic, as well as when solitary or multiple osteolytic lesions are encountered on the radiographs. Additionally, a middle aged woman with parathyroid adenoma and subsequent brown tumors detected on the pelvic radiographs is reported. Her initial laboratory findings indicated a minimal increase of the serum calcium, a mild increase of the erythrocyte sedimentation rate, and a significant increase in total serum alkaline phosphatase. Finally, the detection of elevated parathyroid hormone levels indicated the diagnosis of pHPT and necessitated imaging studies of the parathyroid glands, which indicated a parathyroid adenoma. Following successful excision of the parathyroid adenoma, the patient suffered from the hungry bone syndrome. After a follow-up of 20 years, the patient had normal calcium, vitamin D, and parathyroid hormone serum levels, while a pelvic radiograph indicated no significant changes in the appearance of the brown tumors.

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Unusual pathological fracture of the clavicle revealing primary hyperparathyroidism: a case report

Cited by 4 publications

References 9 publications

Repeat stereotactic body radiotherapy (SBRT) for local recurrence of non-small cell lung cancer and lung metastasis after first SBRT

Repeat stereotactic body radiotherapy (SBRT) for local recurrence of non-small cell lung cancer and lung metastasis after first SBRT

Frequency of superscan on bone scintigraphy: A systematic review

Primary Hyperparathyroidism in the Common Orthopaedic Practice

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