Unusual presentation of a large GIST in an extraintestinal site: a challenging diagnosis dilemma

Ashoor, Arwa; Barefah, Ghaith

doi:10.1136/bcr-2019-229839

Cited by 18 publications

(30 citation statements)

References 23 publications

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“…Over 90% of GISTs show overexpression of the receptor tyrosine kinase KIT (CD117) by immunohistochemistry (IHC), and about 5% are CD117-negative. GIST is also usually associated with CD34 expression in 70% of cases [ 10 ]. Their malignant potential is evaluated using several parameters that include size, location, invasion of adjacent organs, mucosal invasion, cellular architecture, degree of cellularity, mitotic count, nuclear pleomorphism, necrosis, and proliferation [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…There have been reports of EGISTs occurring in the abdominal wall, mesentery and retroperitoneum, lesser omentum, pancreas, and scrotum [ 9 ]. However, the precise incidence and tumor behavior of EGISTs is not clearly understood [ 10 ]. In this report, we present a case of EGIST that originated in the anterior perirectal space, which is an extremely rare location, and we describe the endoscopic approach that was employed to biopsy the tumor.…”

Section: Introductionmentioning

confidence: 99%

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Perirectal Extragastrointestinal Stromal Tumor: An Unusual Presentation

Elagami

Khalid

Kumar

et al. 2021

Cureus

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Gastrointestinal stromal tumors (GISTs), even though rare, remain the most common mesenchymal tumors of the gastrointestinal (GI) tract. When GISTs occur outside of the GI tract, they are termed extragastrointestinal stromal tumors (EGISTs). Most GISTs arise from the stomach (50-70%) and small intestine (20-30%). A smaller percentage of these tumors also occurs in the large intestine (5%) and esophagus (2-5%). EGISTs have histopathological and molecular characteristics that are similar to GISTs. However, the precise incidence and tumor behavior of EGISTs are not fully understood. EGISTs have no specific symptoms or radiologic features, and in most cases, the presenting complaint is abdominal pain or discomfort. Yet, they tend to be more aggressive and have a worse prognosis than GISTs. Morphologic diagnosis based on microscopic examination of histological sections is the standard diagnostic procedure for GIST/EGIST. In this patient-centered study, we present a case of EGIST that originated in the anterior perirectal space, an extremely rare location; we also describe the endoscopic approach that was used to biopsy the tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Perirectal Extragastrointestinal Stromal Tumor: An Unusual Presentation

Elagami

Khalid

Kumar

et al. 2021

Cureus

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“…According to our literature review, this is the first case presentation of a GIST perforating through a diverticular structure within the terminal ileum, producing the unique symptoms observed in the patient. GISTs in other diverticular structures, such as Meckel's diverticulum, have been reported several times [ 8 , 9 ]. The mechanisms surrounding perforation of the GI wall are not fully understood.…”

Section: Discussionmentioning

confidence: 99%

“…About 97% of GISTs are sporadic tumors, and about 20% of affected patients present with overt metastasis at diagnosis [ 6 , 7 ]. GISTs have been reported in unusual abdominal locations including the Meckel's diverticulum [ 8 , 9 ]. GI perforation at the site of the GIST is rare but has been reported [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Unusual Presentation of a Gastrointestinal Stromal Tumor in a Small Intestine Diverticulum

Senti

Torres

Espinosa

et al. 2021

Case Rep Gastroenterol

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A 50-year-old female with no significant medical history initially presented to an urgent care center with symptoms of acute onset abdominal pain, nausea, and emesis. Chest and abdominal X-ray revealed free air under the diaphragm, prompting immediate transfer to the emergency department. Continued abdominal tenderness and pain were concerning for perforated viscus. The patient was transferred to the operating room, and diagnostic laparoscopy was performed. Inflammation and contamination were discovered in the right side of the abdomen and pelvis secondary to a small bowel (SB) perforation. Segmental SB resection revealed a perforated diverticulum. Pathological examination confirmed a diagnosis of gastrointestinal stromal tumor (GIST) at the perforated segment. On postoperative day 5, the patient was discharged home, and at 30-month follow-up, the patient continued to do well. Although rare, SB diverticula are commonly false (i.e., pseudodiverticula). The concomitant presence of a GIST in a true SB diverticulum presenting with perforation has not yet been reported.

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“…Extragastrointestinal stromal tumours (EGISTs) are GISTs that are found outside the digestive tract, and only a few cases have been reported [8][9][10][11]. Approximately 95% of GISTs overexpress KIT (CD117), the immunohistochemistry signature of GISTs which is a receptor protein tyrosine kinase.…”

Section: Introductionmentioning

confidence: 99%

An unusual presentation of an extragastrointestinal stromal tumour: a case report

Santos

Cunha

Lemos³

2020

Egypt J Radiol Nucl Med

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Background: Gastrointestinal stromal tumours (GISTs) account for most mesenchymal gastrointestinal tumours, which in turn represent 1% of all gastrointestinal cancers. They mainly affect older adults, with a slight male preponderance. These lesions can be found along the digestive tract and most frequently in the stomach. Extragastrointestinal stromal tumours (EGISTs) are even rarer lesions, with few cases or series reported. Case presentation: A 51-year-old woman was referred to our hospital due to progressive abdominal volume increase. Evaluation by multidetector computed tomography (MDCT) revealed a large intraperitoneal mixed tumour with few solid components, measuring up to 30 cm and compressing the surrounding structures, thought to be an ovarian tumour. Diagnostic laparotomy showed that the lesion was adherent to the greater gastric curvature and the vesical peritoneum. The lesion was removed without complications. Conclusions: Imaging plays an essential role in the diagnosis of large intraperitoneal tumours. MDCT is the preferred technique to stage and to follow-up EGISTs.

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Unusual presentation of a large GIST in an extraintestinal site: a challenging diagnosis dilemma

Cited by 18 publications

References 23 publications

Perirectal Extragastrointestinal Stromal Tumor: An Unusual Presentation

Perirectal Extragastrointestinal Stromal Tumor: An Unusual Presentation

Unusual Presentation of a Gastrointestinal Stromal Tumor in a Small Intestine Diverticulum

An unusual presentation of an extragastrointestinal stromal tumour: a case report

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