“…1,2 Some of the etiologies include prior pneumonectomy, esophageal foreign body, and sequelae related to malignancies of the esophagus, lung, and mediastinum. 2,3 Clinical manifestations are nonspecific and include fever, subcutaneous emphysema, dyspnea, and pleural effusions. 2 Leakage of digestive contents into the sterile space of the mediastinum and pleura can lead to local response, including acute mediastinitis and pneumonia or systemic response, including sepsis and related shock.…”