Unusual presentation of angiomyomatous hamartoma in an eight-month-old infant: case report and literature review

Abstract

BackgroundEvaluation of palpable neck masses may be a diagnostic problem in pediatric patients, with differential diagnosis including congenital, inflammatory, tumoral and traumatic lesions. Ultrasonography is usually a satisfactory method to make a correct pre-operative evaluation of neck masses, although diagnosis is often challenging for the surgeon and the radiologist and sometimes only possible after a histopathological examination of the resected lesion.Case presentationWe report an 8-month-old patient with a cervical, anterior midline mass. Ultrasonographic images showed features suggesting a partly cystic lesion, with a preoperative suspect of thyroglossal duct cyst. Histological examination, performed after surgical removal of the mass, led to a diagnosis of lymph node angiomyomatous hamartoma (AH).ConclusionsAH, a rarely occurring benign lymph node lesion, has been reported in the neck lateral region only twice. This case, presenting as a palpable neck midline mass, is the first reported case occurring in infancy. Although rare, AH should be included in the differential diagnosis of head and neck masses.

Angiomyomatous Hamartoma of Popliteal Lymph Node: An Unusual Entity

“…Angiomyomatous hamartoma of the lymph node was first described by Chan et al . [ 1 ] in 1992 as a distinctive vascular hamartomatous lesion that primarily occurs in inguinal and femoral lymph nodes [ 2 , 3 ]. Occasional cases have been reported in popliteal and cervical lymph nodes [ 4 , 5 ].…”

“…Angiomyomatous hamartoma (AMH) of the lymph node is characterized by partial replacement of normal nodal parenchyma by disorganized blood vessels and smooth muscle cells with or without adipose tissue within a fibrous stroma. Inguinal and femoral lymph nodes are commonly involved [ 1 - 3 ], while popliteal lymph node involvement is uncommon [ 4 , 5 ]. We report a rare case of AMH of the popliteal lymph node in a young patient with a clinical diagnosis of Baker’s cyst.…”

Primary lymph node hemangioma in a patient with invasive ductal carcinoma

“…Nodal lymphangioma differs from the others, since it tends to affect several organs concomitantly to the lymph node and by the positivity of the D2-40 marker 1,2,6 . Angiomastic hamartoma, on the other hand, was described only in the inguino-femoral region 2 , although it existence has been reported in other locations, such as in the neck and in the popliteal area 9 . The histopathological characteristic is the formation of blood vessels, adipose, muscular and fibrotic tissues by the hilum, as well as lymph node parenchyma without the formation of fascicles.…”

Servikal lenf nodunda lokalize anjiomyomatöz hamartom: Olgu sunumu

“…47) gibi geniş bir yaş aralığında ve sıklıkla erkeklerde izlendiği bildirilmiştir [2]. Bu yaş aralığı dışında literatürde 8 aylık bebek ve 82 yaşında iki ayrı olgu da bulunmaktadır [1,7]. Bu durum AMH'un uzun süreli bozulmuş ve yavaşlamış lenf akımı ile geliştiği hipotezini desteklememektedir.…”