Unusual Presentation of Sarcoidosis

Abstract

The extrapulmonary presentation of sarcoidosis is a frequent occurrence – over 30% of cases when the observation is prospective – but early diagnosis may still be a challenge. A comparison between two different Italian series – (1) patients visiting the Milan Sarcoidosis Clinic of an Internal Medicine Department and (2) an Italian Register from many pneumology centers (RIPID) – has shown a different approach to the diagnosis because pneumologists are more likely to use transbronchial biopsy, while internists are more likely to use extrapulmonary biopsies. Such a different clinical approach may be due in part to a different case mix of the two series.

Gender Differences in Rates of Arrhythmias, Cardiac Implantable Electronic Devices, and Diagnostic Modalities Among Sarcoidosis Patients

“…Sarcoid lesions are most frequently present in the lung but can affect multiple organ systems, with 30% of the patients presenting with extra-pulmonary symptoms, with cardiac involvement carrying a significantly poorer outcome in terms of all-cause mortality [6][7][8][9]. Our study found that among both gender groups, females had a higher prevalence of sarcoidosis (65.2%) as compared to males (34.8%).…”

Necrotizing Granulomata in the Lung Preceding Colonic Involvement in 2 Patients with Crohn’s Disease

“…Chest involvement in IBD is well known, and usually accompanies or follows the intestinal symptomatology. These manifestations include pulmonary function abnormalities, granulomatous inflammation with or without cavitation and drug-related lung disease [4,5,6,7,8,9]. The initial presentation of IBD by respiratory symptoms has not been described before to our knowledge.…”

Dry cough in a middle-aged man

“…[123] It typically affects women in the age group from 20 to 60 years. It is diagnosed pathologically by the presence of noncaseating granulomas on biopsy of the lesion and presents in one or more of the following ways – pulmonary involvement in the form of hilar adenopathy or reticular shadows or extrapulmonary involvement in the form of eye/joint/skin/cardiac/central nervous system lesions.…”