Unusual presentation of seminoma of the testis

Evans, Cyril; Kaufman, H. D.

doi:10.1002/bjs.1800580919

Cited by 10 publications

(2 citation statements)

References 5 publications

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“…We have encountered a patient with stage 1 testicular seminoma, SSN and antineuronal antibodies identified as anti-Hu. Two previous reports describe a possible association between sensorimotor neuropathy and seminoma (Littler 1970, Evans andKaufman 1971). Our patient is the first in whom antineuronal antibodies have been described in association with seminoma and SSN and one of very few in whom treatment has been followed by improvement.…”

Section: Introductionsupporting

confidence: 58%

Sensory neuropathy and anti‐Hu antibodies in a patient with seminoma

Gabriel

Gregson

Hughes

1996

Euro J of Neurology

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Section: Introductionsupporting

confidence: 58%

Sensory neuropathy and anti‐Hu antibodies in a patient with seminoma

Gabriel

Gregson

Hughes

1996

Euro J of Neurology

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“…Surgery and regional lymph node radiotherapy provided rapid improvement in neurological symptoms. No antibodies or EMG results were documented in cases published in the seventies [10, 11].…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic Demyelinating Inflammatory Neuropathy Revealing Metastatic Seminoma: A Case Report

Cherifi

Dereeper²,

Forestier

et al. 2022

Chemotherapy

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Paraneoplastic neurological syndrome (PNS) is uncommon and not well known. PNS can reveal cancer, but its role in seminomas has not been described explicitly. We report the case of a 36-year-old man with unremarkable medical history and no comorbidities who was diagnosed with a retroperitoneal metastatic seminoma. The patient’s general condition deteriorated, and he developed progressive neurological palsy without other clinical anomalies. Electromyography revealed demyelinating, non-lengthy neuropathy. Guillain-Barré syndrome was initially suspected. However, a positron emission tomography scan revealed a retroperitoneal mass, and blood markers revealed increased human chorionic gonadotropin. The patient was diagnosed with PNS, and a computed tomography-guided biopsy revealed a metastatic seminoma without a primary tumor. No circulating neural antibodies were detected. Human polyvalent immunoglobulin was simultaneously administered with chemotherapy. After three cycles of a cisplatin-etoposide-bleomycin, a complete biological and metabolic response rate was observed, and his neurological symptoms rapidly improved. Four years later, the patient responded completely, without any neurological complaints. Paraneoplastic demyelinating inflammatory neuropathy can lead to advanced seminoma diagnosis. Prompt management of seminomas with cisplatin-based regimens provides the best chance of cure for both advanced seminoma and paraneoplastic syndrome.

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Cancer and Cancer Treatment-Related Neuromuscular Disease

Balmaceda¹,

Korkin²

2003

Cancer Neurology in Clinical Practice

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Unusual presentation of seminoma of the testis

Cited by 10 publications

References 5 publications

Sensory neuropathy and anti‐Hu antibodies in a patient with seminoma

Sensory neuropathy and anti‐Hu antibodies in a patient with seminoma

Paraneoplastic Demyelinating Inflammatory Neuropathy Revealing Metastatic Seminoma: A Case Report

Cancer and Cancer Treatment-Related Neuromuscular Disease

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