Unusual presentation of sporadic Burkitt’s lymphoma originating from the nasal septum: a case report

Aslan, Gaffar

doi:10.1186/1752-1947-7-60

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Among extranodal head and neck presentations of sporadic Burkitt lymphoma, the nasopharynx and tonsils were the most common sites of occurrence in one large case series of American sporadic Burkitt lymphoma [ 3 ]. Other extranodal sites of involvement within the head and neck, which occur in less than 5% of patients with sporadic Burkitt lymphoma, include the nasopharynx, tonsils, palate, sinuses, nasal septum, and other facial bones [ 3 , 6 , 11 , 12 ]. This is the first reported case of primary Burkitt lymphoma of the larynx.…”

Section: Discussionmentioning

confidence: 99%

Primary Burkitt lymphoma of the supraglottic larynx: a case report and review of the literature

et al. 2017

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BackgroundBurkitt lymphoma is a high-grade B cell lymphoma which accounts for less than 1% of all adult cases of non-Hodgkin lymphoma. Rare instances of Burkitt lymphoma developing secondary to prior irradiation have been described in the literature.Case presentationWe report a case of a 90-year-old white woman with a recent history of irradiation for Hodgkin lymphoma, who presented with primary Burkitt lymphoma of the supraglottic larynx. She underwent emergency awake tracheostomy with biopsy. A histopathological examination confirmed non-Hodgkin, B cell lymphoma of Burkitt type. Given her age and poor functional status, she underwent treatment with palliative radiotherapy.ConclusionsA literature review was performed to clarify the clinical characteristics of radiation-induced Burkitt lymphoma in the head and neck, as well as its diagnosis and management. The present case represents the second case of radiation-induced Burkitt lymphoma in the head and neck in the reported literature, and the first in the supraglottic larynx. It highlights the need to maintain a broad differential in the assessment of malignancies of the larynx, particularly in patients with a prior history of radiation treatment.

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Section: Discussionmentioning

confidence: 99%

Primary Burkitt lymphoma of the supraglottic larynx: a case report and review of the literature

et al. 2017

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“…Rare cases of sporadic Burkitt lymphoma have been found in specific anatomic regions of the head such as those reported in Europe and Asia by Aslan and Patankar et al, respectively. 11,12 In some low-income health centers where minimally invasive surgical approaches or imaging guided biopsies are not always available, a rapid onset of action with more aggressive measures may clearly help a patient when an uncertain diagnosis arises, increasing the chances of survival and diminishing the risk for potential complications in late-onset treatment.…”

Section: Discussionmentioning

confidence: 99%

Sporadic Burkitt Lymphoma: A Case Report

et al. 2019

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Introduction: Burkitt lymphoma is an aggressive subtype of Hodgkin lymphoma with a doubling time of 25 hours. It is characterized by a MYC gene coding alteration which results from a translocation of chromosome 8 on the MYC gene locus and immunoglobulin heavy-chain locus (IGH) on chromosome 14. Even though HIV infection is associated to an increased risk of Burkitt lymphoma, these type of malignancies are EBV-negative cases. Sporadic type Burkitt lymphoma is a rare clinical entity. Case Presentation: A 48-year-old female without any past medical history presented with a chief complaint of mild abdominal pain of 6 months duration located at the epigastrium which was not related to food ingestion. Nausea or vomiting were neither reported. She noted an acute increased abdominal pain over the last 4 hours before presentation, with irradiation to the right lower quadrant. She denied any Fever, night sweats and weight loss. She also reported hypermenorrhea in the last 6 months. During the physical examination, a palpable mass with 10 cm in diameter was found on right lower quadrant. Conclusion: Sporadic Burkitt lymphoma is one of the rarest hematologic malignancies. The increased tumor size may be more than enough to show clinical or biochemical abnormalities such as serum lactate dehydrogenase (LDH) increased and tumor lysis.

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“…The nose and paranasal sinuses, orbit(s), salivary glands are other sites in head and neck affected in descending order of frequency [11][12][13]. It generally affects the elderly, especially over the 6th decade of life, and the male: female ratio was 2:1 [14].…”

Section: Discussionmentioning

confidence: 99%

“…Another hypothesis suggested that lymphomas develop as a result of imbalanced immunoregulation, however in the great majority of malignant lymphomas; there is no overt immunologic abnormality. Malignant lymphomas are thought to arise in the oral cavity from components of the lymphoreticular system in the oral submucosa, usually Waldeyer's ring [9,11,12].…”

Section: Discussionmentioning

confidence: 99%

Primary Small B-cell Lymphoma (MALT Lymphoma) at Lingual Tonsil: A Case Report

Aslan

2014

BJMMR

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Aims: Primary non-Hodgkin's lymphomas of the oropharyngeal region are rare. We report a case of a small B-cell lymphoma (MALT lymphoma) involving base of tongue. The patient was successfully treated with wide excision of the lesion followed by radiotherapy. Presentation of Case: A 75-year-old female Caucasian patient was referred to our clinic with complaints of foreign body sensation in the throat and progressively worsening snoring over 4 months. Oropharyngeal examination revealed a 3x3-cm smooth mass originating from the left side of the base of tongue and moving with protrusion of the tongue. Excisional biopsy revealed a low-grade small B-cell lymphoma with lambda monoclonal plasmacytic differentiation [extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue (MALT) with lambda monoclonal plasmacytic differentiation]. The neoplastic population was consisted of small lymphoid B-cells and lambda Case Studymonoclonal plasma cells. Lymphoid cells showed CD20(+), CD5(-), CD23(-), CD10(-), BCL-6(-), IgD(-), BCL-2(+). In the neoplasm were seen few mitoses, and cellular proliferation marker Ki-67 was approximately 15%. Magnetic resonance imaging of the head and neck showed a well-circumscribed solid mass originating from the base of left side tongue. Bone marrow aspiration biopsy showed no evidence of disease. Computerized tomographic scans of the thorax and magnetic resonance imaging of the abdomen showed no adenopathy. Tumor was determined to be at Stage I. Discussion and Conclusion: Primary non-Hodgkin's lymphomas involving oropharyngeal region should be considered in differential diagnosis of all lesions located in this region. To our knowledge, a case of small B-cell lymphoma of the base of the tongue is rarely reported. An appropriate evaluation of the clinical presentation along with histopathologic and immunohistochemical evaluation of biopsy specimen may aid in the diagnosis and effective treatment.

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Unusual presentation of sporadic Burkitt’s lymphoma originating from the nasal septum: a case report

Cited by 5 publications

References 18 publications

Primary Burkitt lymphoma of the supraglottic larynx: a case report and review of the literature

Primary Burkitt lymphoma of the supraglottic larynx: a case report and review of the literature

Sporadic Burkitt Lymphoma: A Case Report

Primary Small B-cell Lymphoma (MALT Lymphoma) at Lingual Tonsil: A Case Report

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