Unusual presentation of uterine tumors resembling ovarian sex cord tumor: A rare case report of cervical involvement

Sahraoui, Ghada; Sassi, Farah; Charfi, Lamia; Ltaief, Feriel; Doghri, Raoudha; Mrad, Karima

doi:10.1016/j.ijscr.2023.108477

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…As regards age, this neoplasm often occurs in perimenopausal or menopausal women [19]. However, in a more recent and large series reported by Boyraz et al, the patients' age ranged from 21-84 (mean: 52.4; median: 53) years [20], moreover in the literature many cases have been reported in which the patients can be <40 years [16,[21][22][23][24][25][26][27][28][29][30][31][32] or are very young [33,34].…”

Section: Clinical Datamentioning

confidence: 99%

“…More rarely, a UTROSCT can be observed in the cervix. In fact, in the literature we found only four cases [21,33,37,67] that presented as cervical masses, mimicking a primary cervical carcinoma on instrumental tests, such as Computed Tomography (CT) or pelvic Magnetic Resonance Imaging (MRI), on macroscopic, histologic and cytologic examination. So, as emphasized by Dubruc et al, it is important to keep in mind that UTROSCTs can also be encountered in current cervical screening programs, and in this occurrence, can be responsible for diagnostic pitfalls [67].…”

Section: Macroscopic Findingsmentioning

confidence: 99%

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Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Rare Polyphenotypic Neoplasm

Giordano,

Guareschi,

Thai

2024

Preprint

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Uterine Tumor Resembling Ovarian Sex Cord Stromal Tumor (UTROSCT) is a rare uterine mesenchymal neoplasm, which resembles ovarian sex cord tumors of the ovary. Although, in general, UTROSCT exhibits benign behavior with a favorable prognosis, this neoplasm is nonetheless classified as being of an uncertain ma-lignant potential, given its low rate of recurrence and the fact that it rarely pro-duces metastases (lymph nodes, epiploic appendix, omentum, small bowel, subcutaneous, lungs). Its histogenesis too is uncertain. Typically, UTROSCT oc-curs in peri-menopausal or menopausal women but can sometimes be observed in young women. Usually, this neoplasm can be found in the uterine corpus as a nodular intramural lesion, less frequently submucosal, subserosal or poly-poid/intracavitary. UTROSCT can cause abnormal bleeding, pelvic pain, enlarged uterus, mass sensation, but sometimes it is found purely by chance. This neo-plasm can be considered polyphenotypic on morphological, immunohistochem-ical, and genetic analyses. Generally, on microscopic examination, UTROSCT shows a predominant pattern of the cords, nests, and trabeculae typical of sex cord tumors of the ovary while, immunohistochemically, it is characterized by a co-expression of epithelial, smooth muscle, and sex cord markers. The aim of this review is to report clinical and pathological data and genetic alterations to estab-lish its impact on the prognosis and management of patients affected by this rare entity.

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Section: Clinical Datamentioning

confidence: 99%

Section: Macroscopic Findingsmentioning

confidence: 99%

Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Rare Polyphenotypic Neoplasm

Giordano,

Guareschi,

Thai

2024

Preprint

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“…However, in a more recent and large series reported by Boyraz et al, the patients’ age ranged from 21 to 84 years (mean: 52.4; median: 53) [ 20 ]. Moreover, in the literature, many cases have been reported in which the patients were aged < 40 years [ 16 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ] or even very young women [ 33 , 34 ]. The most common symptom found is abnormal vaginal bleeding (67.1%) [ 35 ].…”

Section: Clinical Datamentioning

confidence: 99%

“…More rarely, a UTROSCT has been observed in the cervix. In fact, in the literature, we found only four cases [ 21 , 33 , 37 , 64 ] that presented as cervical masses, mimicking a primary cervical carcinoma on instrumental tests such as computed tomography (CT) or pelvic magnetic resonance imaging (MRI), as well as on macroscopic, histological, and cytological examination. Thus, as emphasized by Dubruc et al, it is important to keep in mind that UTROSCTs can also be encountered in current cervical screening programs, in which case they can be responsible for diagnostic pitfalls [ 64 ].…”

Section: Pathological Featuresmentioning

confidence: 99%

Uterine Tumor Resembling Ovarian Sex-Cord Tumor (UTROSCT): A Rare Polyphenotypic Neoplasm

Giordano,

Guareschi,

Thai

2024

Diagnostics

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Uterine tumor resembling ovarian sex-cord tumor (UTROSCT) is a rare form of uterine mesenchymal neoplasm. Although UTROSCT generally exhibits benign behavior with a favorable prognosis, this neoplasm is nevertheless classified as being of uncertain malignant potential, given its low rate of recurrence and the fact that it rarely produces metastases (e.g., in the lymph nodes, epiploic appendix, omentum, small bowel, subcutaneous tissue, lungs). Its histogenesis is also uncertain. Typically, UTROSCT occurs in peri-menopausal or menopausal women, but it can sometimes be observed in young women. Usually, this neoplasm can be found in the uterine corpus as a nodular intramural lesion, while it is less frequently submucosal, subserosal, or polypoid/intracavitary. UTROSCT can cause abnormal bleeding, pelvic pain, enlarged uterus, and mass sensation, but sometimes it is found purely by chance. This neoplasm can be considered polyphenotypic on morphological, immunohistochemical, and genetic analyses. Generally, upon microscopic examination, UTROSCT shows a predominant pattern of the cords, nests, and trabeculae typical of sex-cord tumors of the ovary, while immunohistochemically it is characterized by a coexpression of epithelial, smooth muscle, and sex-cord markers. The aim of this review is to report clinical and pathological data and genetic alterations to establish their impact on the prognosis and management of patients affected by this rare entity.

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Uterine Tumors Resembling Ovarian Sex Cord Tumors (UTROSCTs): A Scoping Review of 511 Cases, Including 2 New Cases

Watrowski,

Palumbo,

Guerra

et al. 2024

Medicina

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Uterine Tumors Resembling Ovarian Sex Cord Tumors (UTROSCTs) are rare uterine mesenchymal neoplasms with uncertain biological potential. These tumors, which affect both premenopausal and postmenopausal women, usually have a benign clinical course. Nevertheless, local recurrences and distant metastases have been described. By analyzing 511 cases retrieved from individual reports and cases series, we provide here the most comprehensive overview of UTROSCT cases available in the literature, supplemented by two new cases of UTROSCTs. Case 1 was an asymptomatic 31-year-old woman who underwent a laparoscopic resection of a presumed leiomyoma. Case 2 was a 58-year-old postmenopausal woman with abnormal vaginal bleeding who underwent an outpatient hysteroscopic biopsy of a suspicious endometrial area. In both cases, immunohistochemical positivity for Calretinin and Inhibin was noted, typical for a sex cord differentiation. In both cases, total laparoscopic hysterectomy with bilateral salpingo-oophorectomy was performed. In light of the available literature, no pathognomonic clinical or imaging finding can be attributed to UTROSCT. Patients usually present with abnormal uterine bleeding or pelvic discomfort, but 20% of them are asymptomatic. In most cases, a simple hysterectomy appears to be the appropriate treatment, but for women who wish to become pregnant, uterus-preserving approaches should be discussed after excluding risk factors. Age, tumor size, lymphovascular space invasion, nuclear atypia, and cervical involvement are not reliable prognostic factors in UTROSCT. The current research suggests that aggressive cases (with extrauterine spread or recurrence) can be identified based on a distinct genetic and immunohistochemical phenotype. For instance, UTROSCTs characterized by GREB1::NCOA1-3 fusions and PD-L1 molecule expression appear to be predisposed to more aggressive behaviors and recurrence, with GREB1::NCOA2 being the most common gene fusion in recurrent tumors. Hence, redefining the criteria for UTROSCTs may allow a better selection of women suitable for fertility-sparing treatments or requiring more aggressive treatments in the future.

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Unusual presentation of uterine tumors resembling ovarian sex cord tumor: A rare case report of cervical involvement

Cited by 3 publications

References 11 publications

Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Rare Polyphenotypic Neoplasm

Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Rare Polyphenotypic Neoplasm

Uterine Tumor Resembling Ovarian Sex-Cord Tumor (UTROSCT): A Rare Polyphenotypic Neoplasm

Uterine Tumors Resembling Ovarian Sex Cord Tumors (UTROSCTs): A Scoping Review of 511 Cases, Including 2 New Cases

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