Unusual seminoma revealed by bone metastasis

Braquet, P.; Chapelle, Angélique; Jørgensen, Christian; Pers, Yves-Marie

doi:10.1016/j.jbspin.2011.05.012

Cited by 2 publications

(4 citation statements)

References 6 publications

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“…Treatment strategies like Imatinib in metastatic seminoma and other targeted agents have recently shown promise. [15] To summarize this is a rare case of PMS with earlier age of presentation with features of SVCO. The poor response to platinum based chemotherapy is uncommon and a poor prognostic marker although there was a complete "metabolic and biochemical response" postchemo-radiotherapy.…”

Section: Discussionmentioning

confidence: 86%

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Primary mediastinal seminoma; resistance and relapse: An aggressive entity

Nachankar

Krishnatry

Joshi

et al. 2013

Indian Journal of Medical and Paediatric Oncology

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Seminoma is one of the most radio and chemo sensitive tumors. Aggressive variant of primary mediastinal seminoma (PMS) are rarely described in the literature. We here discuss an interesting case of young male (22 years) presenting with superior vena cava syndrome due to PMS that showed poor response to conventional platinum based chemotherapy and radiotherapy. Furthermore, with a short disease free interval (one year) relapsed at unusual sites of bone and soft-tissue deposits in check. This emphasizes the importance of identifying methods to pre-screen such aggressive variants for more effective treatment options.

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Section: Discussionmentioning

confidence: 86%

“…Treatment strategies like Imatinib in metastatic seminoma and other targeted agents have recently shown promise. [15]…”

Section: Discussionmentioning

confidence: 99%

Primary mediastinal seminoma; resistance and relapse: An aggressive entity

Nachankar

Krishnatry

Joshi

et al. 2013

Indian Journal of Medical and Paediatric Oncology

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“…The distributional pattern of 18 F-FDG-PET/CT with involvement of lymph nodes and liver was typical for seminoma, but bone metastases are more a rare case in this tumor. 10 Untypical was the relative low medium SUV in the observed lesions of 3.3 with a maximum of 5.7, which indicates an inflammatory lesion. Therefore, a biopsy of a mediastinal lymph node was performed, which showed a histological finding of a sarcoidosis.…”

Section: Discussionmentioning

confidence: 95%

“…lung malignancy and lymphomas. [9][10][11][12] With the increasing use of 18 FDG-PET/CT it is necessary to differentiate sarcoidosis, sarcoid-like reactions and tumor involvement.…”

Section: Introductionmentioning

confidence: 99%

False-positive finding in FDG-PET in a patient with seminoma and sarcoidosis

Liepe

2014

Acta Clinica Belgica

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A 33-year-old white man with testicular cancer (seminoma) stage IIIa showed a response in mediastinal lymph node metastases after chemotherapy. However, the tumor markers increase slightly, and therefore an (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography was performed. Multiple FDG avid lesions were found in lymph node, liver and bone. The standardized uptake value (SUV) was discrete increase with a value of 2·8 to 5·7, which is more typical for inflammatory disease than a malignancy. The histological findings in a mediastinal lymph node reported a sarcoidosis, and therefore all lesions were diagnosed as a sarcoidosis. The one-year follow-up showed no further increase in tumor markers and no evidence for metastases.

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Unusual seminoma revealed by bone metastasis

Cited by 2 publications

References 6 publications

Primary mediastinal seminoma; resistance and relapse: An aggressive entity

Primary mediastinal seminoma; resistance and relapse: An aggressive entity

False-positive finding in FDG-PET in a patient with seminoma and sarcoidosis

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