Unusual Skin Involvement in Statin-induced Anti-HMGCR Immune-mediated Necrotizing Myopathy

Scard, C.; Bara-Passot, C.; Chassain, K.; Maillard, H.

doi:10.2340/00015555-3645

Cited by 11 publications

(10 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4e, f). These lymphocytic infiltrations are similar to Jessner-Kanoff lymphocytic infiltration or low-grade cutaneous lymphoma [26 ▪ ,27 ▪ ].…”

Section: Histopathological Manifestationssupporting

confidence: 53%

“…However, the incidence of anti-HMGCR antibody in Jessner-Kanoff disease or cutaneous lymphoma is still unknown. Other extramuscular manifestations including cardiac and pulmonary involvement have been considered to be part of HMGCR-IMNM on rare occasions [15,26 ▪ ,27 ▪ ,43,45,60].…”

Section: Clinical Symptoms: Focus On the Difference Between Hmgcr-imn...mentioning

confidence: 99%

“…For HMGCR-IMNM patients, the frequency of extramuscular manifestations was low. However, several studies have reported skin conditions in these patients, including Raynaud phenomenon, a nonspecific skin rash and dermatomyositis-like skin eruptions [11,15,26 ▪ –29 ▪ ,50]. HMGCR-IMNM patients with skin conditions usually develop pruritic erythematous papules with photosensitivity (Fig.…”

Section: Clinical Symptoms: Focus On the Difference Between Hmgcr-imn...mentioning

confidence: 99%

“…HMGCR-IMNM patients with skin conditions usually develop pruritic erythematous papules with photosensitivity (Fig. 1E, F) [28 ▪ ,29 ▪ ,50] and sometimes show the dermatological presentations of Jessner-Kanoff disease or cutaneous lymphoma [26 ▪ ,27 ▪ ]. However, the incidence of anti-HMGCR antibody in Jessner-Kanoff disease or cutaneous lymphoma is still unknown.…”

Section: Clinical Symptoms: Focus On the Difference Between Hmgcr-imn...mentioning

confidence: 99%

See 3 more Smart Citations

Anti-HMGCR myopathy: clinical and histopathological features, and prognosis

Kurashige

2021

Current Opinion in Rheumatology

View full text Add to dashboard Cite

Purpose of reviewThis review aims to describe clinical and pathological features, prognosis and treatment in patients with anti-HMGCR antibody positive immune-mediated necrotizing myopathy (HMGCR-IMNM) based on recent findings.Recent findingsUsing advances in diagnostic modalities that can confirm the presence of anti-HMGCR antibody, the clinical and pathological manifestations of HMGCR-IMNM were found to be broader than previously reported. Although only a small percentage of HMGCR-IMNM patients present with atypical manifestations, some of these patients show slow disease progression and clinical symptoms, which are similar to those of limb-girdle muscular dystrophies. Other atypical HMGCR-IMNM patients have skin conditions similar to dermatomyositis-like skin rush or dermatological presentations of Jessner-Kanoff disease or cutaneous lymphoma, whose pathological changes including CD8-positive and bcl-2-positive lymphocytic accumulations, similar to Jessner-Kanoff lymphocytic infiltration of skin or low-grade cutaneous lymphoma, which are observed in muscle and skin.SummaryAnti-HMGCR autoantibodies define unique populations of IMNM patients. Recent studies have revealed that clinicopathological manifestations of HMGCR-IMNM, especially extramuscular symptoms and pathological manifestations, are more common than previously recognized.

show abstract

“…4e, f). These lymphocytic infiltrations are similar to Jessner-Kanoff lymphocytic infiltration or low-grade cutaneous lymphoma [26 ▪ ,27 ▪ ].…”

Section: Histopathological Manifestationssupporting

confidence: 53%

Section: Clinical Symptoms: Focus On the Difference Between Hmgcr-imn...mentioning

confidence: 99%

Section: Clinical Symptoms: Focus On the Difference Between Hmgcr-imn...mentioning

confidence: 99%

Section: Clinical Symptoms: Focus On the Difference Between Hmgcr-imn...mentioning

confidence: 99%

See 2 more Smart Citations

Anti-HMGCR myopathy: clinical and histopathological features, and prognosis

Kurashige

2021

Current Opinion in Rheumatology

View full text Add to dashboard Cite

show abstract

“…Skin changes are present in 4%‐6% of anti‐SRP or anti‐HMGCR IMNM patients; some were clinically suspected as having “DM” 51,53,54,77‐79 . ASS or DM muscle samples biopsied from severe patients or severely damaged sites occasionally exhibit diffuse necrosis, not limited to the perifascicular area, mimicking IMNM pathology (especially in anti‐OJ and anti‐Mi‐2 cases).…”

Section: Mechanismmentioning

confidence: 99%

Autoimmune myositis—Mechanism and therapy development

Uruha

2021

Neurology & Clinical Neurosc

View full text Add to dashboard Cite

Over the recent decades, notable progress has been made in the understanding of the pathomechanism of autoimmune myositis. Dermatomyositis is considered a type I interferonopathy, distinctive from antisynthetase syndrome despite some common clinical features. Immune-mediated necrotizing myopathy is related to complementmediated autoimmunity. In inclusion body myositis, myofiber invasion by highly differentiated cytotoxic T cells leads to myofiber damage. Based on the accumulated knowledge, targeted, more mechanism-focused therapies are being developed.

show abstract