Unusual Skin Reactions after Mosquito Bites and Epstein-Barr Virus Reactivation in a Patient with Mantle Cell Lymphoma

Shigekiyo, Toshio; Ohmori, Hidenobu; Chohraku, Masahito; Ohtsuka, S.; Yamabe, Kazue; Takishita, Yoshihiro; Takai, Shigeharu; Takahashi, Masanori; Wakatsuki, Soichi

doi:10.2169/internalmedicine.43.986

Cited by 17 publications

(12 citation statements)

References 13 publications

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“…Although rare, the association of insect‐bite‐like eruptions and lymphoproliferative malignancies (especially chronic lymphocytic leukaemia) is well established 27–31 . To the best of our knowledge, this is the first reported case of insect‐bite‐like Wells’ syndrome with a clinicopathological correlation, associated with the development of mantle‐cell lymphoma.…”

Section: Discussionmentioning

confidence: 75%

Insect-bite-like Wells’ syndrome in association with mantle-zone lymphoma

Zeeli

Feinmesser

Segal

et al. 2006

British Journal of Dermatology

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Wells' syndrome is a multifaceted dermatosis with a wide morphological spectrum, ranging from characteristic cellulitis-like erythema and wheals to an unusual presentation of vesicles and bullae. We describe a patient in whom Wells' syndrome presented as an insect-bite-like eruption and was associated with underlying mantle-cell lymphoma. We recommend meticulous investigation of patients diagnosed with Wells' syndrome manifesting as an insect-bite-like eruption.

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Section: Discussionmentioning

confidence: 75%

Insect-bite-like Wells’ syndrome in association with mantle-zone lymphoma

Zeeli

Feinmesser

Segal

et al. 2006

British Journal of Dermatology

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“…It is seen mostly in the first two decades of life, and some cases are associated with EpsteinBarr virus (EBV) infection and natural killer (NK) cell leukemia/lymphoma (1). Shigekiyo et al reported a mantle cell lymphoma (MCL) patient with HMB, which thus suggested a relationship between EBV and MCL (2). On the other hand, Mori et al reported a patient with HMB who developed MCL, which suggested that HMB might be a pathophysiologic condition with a malignant potential (3).…”

Section: Introductionmentioning

confidence: 99%

Hypersensitivity to Mosquito Bites as a Potential Sign of Mantle Cell Lymphoma

Kunitomi¹,

Konaka²,

Yagita³

2005

Intern. Med.

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Hypersensitivity to mosquito bites (HMB) is known to be an allergic reaction and also a skin symptom in some cases of natural killer cell leukemia/lymphoma associated with Epstein-Barr virus (EBV) infection. We describe a patient who had suffered from HMB for 5 years, and subsequently developed mantle cell lymphoma (MCL), which resembled chronic lymphocytic leukemia in the early phase. EBV monoclonality was not detected in lymph nodes by Southern blotting. Serum levels of interleukin-4 and IgE were increased, but they decreased and HMB disappeared when MCL was predominant. We consider that HMB may be a potential sign of MCL.

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“… 3 , 4) Although exceptional cases of HMB have been reported in patients with chronic lymphocytic leukemia or mantle cell lymphoma without evidence of an EBV infection, no cases of HMB associated with anaplastic large cell lymphoma (ALCL) have yet been reported. 5 , 6) In this study, we report the first case of HMB associated with ALCL.…”

Section: Introductionmentioning

confidence: 83%

“… 1 , 2 , 3 , 4) However, not all cases of HMB develop into NK cell leukemia/lymphoma. 2 , 5 , 6 , 7 , 8) Shigekiyo et al 5) reported a case of HMB developing into mantle cell lymphoma, and Konuma et al 8) and Seon et al 2) also reported cases of HMB that did not develop into NK/T-cell proliferative diseases. To date, 7 patients with HMB have been reported in Korea, including 3 patients with lymphoid neoplasms such as NK cell lymphoma, Hodgkin's lymphoma-like B-cell lymphoproliferative disorder, and marginal zone B-cell lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma Arising in a Patient with Hypersensitivity to Mosquito Bites

et al. 2015

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Hypersensitivity to mosquito bites is defined as the appearance of intense skin reactive lesions and systemic symptoms subsequent to mosquito bites. Most cases of hypersensitivity to mosquito bites reported thus far have been associated with chronic Epstein-Barr virus infection or natural killer cell leukemia/lymphoma. In this study, we describe the case of an 18-year-old Korean boy who had hypersensitivity to mosquito bites associated with primary systemic anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. After a mosquito bite, the patient developed a progressive cutaneous nodule on his left lower leg and regional lymphadenopathy in the left inguinal area. The histopathological and immunohistochemical findings suggested anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Positron emission tomography-computed tomography revealed increased fluorodeoxyglucose uptake in the left T4 vertebrae, left external iliac lymph nodes, left inguinal lymph nodes, and lateral subcutaneous region of the left lower leg. According to the clinical, histopathological, and immunohistochemical findings, as well as the imaging data, the patient was diagnosed with primary systemic anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Consequently, the patient received a total of 6 cycles of cyclophosphamide + doxorubicin + vincristine + prednisolone chemotherapy at 3-week intervals, after which the lesions regressed.

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Unusual Skin Reactions after Mosquito Bites and Epstein-Barr Virus Reactivation in a Patient with Mantle Cell Lymphoma

Cited by 17 publications

References 13 publications

Insect-bite-like Wells’ syndrome in association with mantle-zone lymphoma

Insect-bite-like Wells’ syndrome in association with mantle-zone lymphoma

Hypersensitivity to Mosquito Bites as a Potential Sign of Mantle Cell Lymphoma

Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma Arising in a Patient with Hypersensitivity to Mosquito Bites

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