Unusual Tc-99m MDP and 1-123 MIBG Images in Focal Pyelonephritis

Jacobs, A.; Lenoir, Pascal; Delree, M; Ramet, J. P.; Piepsz, Amy

doi:10.1097/00003072-199011000-00013

Cited by 26 publications

(10 citation statements)

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“…Renal calculi and focal renal inflammation 34 may produce areas of focal 99m Tc MDP uptake (Fig.15). These can also cause a large photopenic defect in the renal pelvis if they do not accumulate 99m Tc MDP 1 .…”

Section: Abdominal Uptake Of Mdpmentioning

confidence: 99%

Soft tissue uptake on ^99mTc methylene diphosphonate bone scan imaging: Pictorial review

Kaye

Hayward

2002

Australasian Radiology

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99mTechnetium methylene diphosphonate (MDP) bone isotope may accumulate in many extra-osseous sites due to a variety of both benign and malignant conditions. This finding on a bone scan can be crucial to the diagnosis and may not be apparent in other imaging or the clinical evaluation of the patient. We present a pictorial review sampling some of the many causes of extra-osseous 99mTc MDP accumulation.

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Section: Abdominal Uptake Of Mdpmentioning

confidence: 99%

Soft tissue uptake on ^99mTc methylene diphosphonate bone scan imaging: Pictorial review

Kaye

Hayward

2002

Australasian Radiology

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“…In our case, the initial misleading strong positive MIBG scintigraphic uptake was a false-positive finding with the clinical and finally histological findings. The uptake was probably caused by inflammatory involvement of the left adrenal gland with still unknown uptake mechanism [7]. In addition to antibiotics, the treatment of choice for retroperitoneal actinomycosis is interventional drainage of the abscess.…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal Actinomycosis Mimicking a Malignant Neoplasm of Adrenal Gland

et al. 2015

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Actinomycosis is a chronic disease characterized by abscess formation, tissue fibrosis, and draining sinuses. In this study, we aimed to present the clinical and radiological findings of a rare pathology, retroperitoneal actinomycosis case mimicking adrenal tumor and review the literature. Physicians must be aware of typical clinical presentations (such as cervicofacial actinomycosis following dental focus of infection, pelvic actinomycosis in women with an intrauterine device, and pulmonary actinomycosis in smokers with poor dental hygiene), but also that actinomycosis may mimic the malignancy process in various anatomical sites. Actinomycosis manifests as tumor-like lesions mainly in the cranio-cervical region (60-80%), thorax (10-15%), abdomen (5-20%) and exceptionally in retroperitoneal organs. Positron emission tomography (PET) revealed hypermetabolic mass lesion 63 × 52 × 73 mm in size on the left adrenal gland showed a standardized uptake value (SUV) of 18.2. The patient underwent left adrenalectomy. The pathologic examination revealed actinomycosis. The patient was treated with antibiotics.

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“…Accumulation of MIBG in benign or nonmalignant sites can potentially result in false-positive MIBG examinations. A review of the literature reveals a list of benign entities described to accumulate MIBG, including the following: atelectasis (Fig 11) (36), pneumonia (37), focal nodular hyperplasia in the liver (38), radiation injury of the liver (39), a large accessory spleen (40), focal pyelonephritis (41), and vascular malformations (42,43). Some of these false-positive results can be mitigated with use of SPECT/CT, which provides correlative anatomic information.…”

Section: Reported Causes Of False-positive Uptakementioning

confidence: 99%

MIBG in Neuroblastoma Diagnostic Imaging and Therapy

Sharp¹,

Trout²,

Weiss³

et al. 2016

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Neuroblastoma is a common malignancy observed in infants and young children. It has a varied prognosis, ranging from spontaneous regression to aggressive metastatic tumors with fatal outcomes despite multimodality therapy. Patients are divided into risk groups on the basis of age, stage, and biologic tumor factors. Multiple clinical and imaging tests are needed for accurate patient assessment. Iodine 123 ((123)I) metaiodobenzylguanidine (MIBG) is the first-line functional imaging agent used in neuroblastoma imaging. MIBG uptake is seen in 90% of neuroblastomas, identifying both the primary tumor and sites of metastatic disease. The addition of single photon emission computed tomography (SPECT) and SPECT/computed tomography to (123)I-MIBG planar images can improve identification and characterization of sites of uptake. During scan interpretation, use of MIBG semiquantitative scoring systems improves description of disease extent and distribution and may be helpful in defining prognosis. Therapeutic use of MIBG labeled with iodine 131 ((131)I) is being investigated as part of research trials, both as a single agent and in conjunction with other therapies. (131)I-MIBG therapy has been studied in patients with newly diagnosed neuroblastoma and those with relapsed disease. Development and implementation of an institutional (131)I-MIBG therapy research program requires extensive preparation with a focus on radiation protection.

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Unusual Tc-99m MDP and 1-123 MIBG Images in Focal Pyelonephritis

Cited by 26 publications

References 0 publications

Soft tissue uptake on ^99mTc methylene diphosphonate bone scan imaging: Pictorial review

Soft tissue uptake on ^99mTc methylene diphosphonate bone scan imaging: Pictorial review

Retroperitoneal Actinomycosis Mimicking a Malignant Neoplasm of Adrenal Gland

MIBG in Neuroblastoma Diagnostic Imaging and Therapy

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Unusual Tc-99m MDP and 1-123 MIBG Images in Focal Pyelonephritis

Cited by 26 publications

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Soft tissue uptake on 99mTc methylene diphosphonate bone scan imaging: Pictorial review

Soft tissue uptake on 99mTc methylene diphosphonate bone scan imaging: Pictorial review

Retroperitoneal Actinomycosis Mimicking a Malignant Neoplasm of Adrenal Gland

MIBG in Neuroblastoma Diagnostic Imaging and Therapy

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Soft tissue uptake on ^99mTc methylene diphosphonate bone scan imaging: Pictorial review

Soft tissue uptake on ^99mTc methylene diphosphonate bone scan imaging: Pictorial review