Unusually High Concentration of Fentanyl in a Driver: A Case Report

In recent years, fentanyl is increasingly detected in overdose cases as well as human performance cases due to the current opioid epidemic. The comparison of fentanyl concentrations in deaths to recreational fentanyl use found in driving under the influence of drugs (DUID) cases is important to show how increased availability effects the historical knowledge of fentanyl. A two-year review of fentanyl cases from Orange County, CA, USA is presented to highlight fentanyl concentrations in these two case types. Any non-urine sample with fentanyl detected above the limit of detection of 0.5 ng/mL was reviewed in DUID and postmortem cases. The mean and median fentanyl concentrations in 199 antemortem blood samples from DUID cases were 14.2 ng/mL and 5.3 ng/mL, respectively, with a range of 0.5–303 ng/mL. In 285 central blood samples from postmortem cases the mean was 29.1 ng/mL, the median was 16.9 ng/mL and the range was 0.6–636 ng/mL. In a total of 58 postmortem peripheral blood samples, the mean, median and range were 14.0 ng/mL, 10.0 ng/mL and 0.9–78.0 ng/mL, respectively. Of the 55 brain samples analyzed, the fentanyl mean, median and range of fentanyl concentrations were 50.0 ng/g, 31.4 ng/g and 1.9–441 ng/g, respectively. Fentanyl concentrations in 16 liver samples had a mean of 82.0 ng/g, a median of 69.4 ng/g and a range of 11.6–226 ng/g. The overlap of fentanyl concentrations from the antemortem and postmortem samples highlights the importance of evaluating case circumstances when providing an interpretation in postmortem cases. Additional information such as age, gender, polydrug use, and postmortem redistribution is presented for the cases included in the study.

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A Comparison of High Drug Concentrations in Impaired Driving and Postmortem Casework in Harris County, TX

Dempsey

Gray

Kelly

et al. 2022

Journal of Analytical Toxicology

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Drug-impaired driving is a growing public safety issue. Addressing impairment due to drugs other than ethanol can be challenging for forensic toxicologists as many factors need to be considered including the type of drug(s), drug-drug interaction, the dose(s), and the individual’s physiological condition and drug use history. Interpretation of blood drug test results is additionally difficult as drug concentrations in impaired driving cases may overlap levels typically viewed as toxic. This study compares blood concentrations of drugs in impaired driving cases to those in postmortem cases in Houston, Texas from 2014 to 2020. Blood drug concentrations from driving while intoxicated (DWI) or driving under the influence of drugs (DUID) cases submitted to Houston Forensic Science Center (HFSC) and Harris County Institute of Forensic Sciences (HCIFS) were compared to postmortem blood test results from HCIFS. Eight DWI/DUID cases had drugs that exceeded impaired driving concentrations reported in literature. These drugs included fentanyl (220 ng/mL), oxycodone (680 ng/mL), hydrocodone (310 and 490 ng/mL), clonazepam (330 ng/mL), methamphetamine (3500 and 7100 ng/mL), and THC (160 ng/mL). For oxycodone and hydrocodone, the presented DWI/DUID cases exceeded 91% and 96% of postmortem concentrations, respectively. The 7100 ng/mL methamphetamine DWI/DUID result was greater than 98% of postmortem cases. The presented DWI/DUID concentrations were higher than all but one postmortem case for clonazepam and higher than all postmortem cases for THC. This study demonstrates extremely high drug concentrations in DWI/DUID casework blur the line between therapeutic/recreational and toxic concentrations.

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Unusually High Concentration of Fentanyl in a Driver: A Case Report

Cited by 7 publications

References 3 publications

Interpol review of toxicology 2019–2022

Interpol review of toxicology 2019–2022

A Two-Year Review of Fentanyl in Driving under the Influence and Postmortem Cases in Orange County, CA, USA

A Comparison of High Drug Concentrations in Impaired Driving and Postmortem Casework in Harris County, TX

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