Unusually High Levels of CA19-9 Associated with Mature Cystic Teratoma of the Ovary

Abstract

Introduction. Mature cystic teratoma is the benign tumor of the ovary. CA19-9 levels, although a marker of pancreatic malignancy, have been found to be raised in large ovarian mature cystic teratomas. Case Report. We report a case of a young female who had unusually high levels of CA19-9 in the blood associated with large ovarian mature cystic teratoma. The levels returned to normal 12 weeks after cystectomy was performed. Conclusion. This case highlights the fact that although raised tumor marker may be associated with a benign pathology thorough evaluation to rule out malignancy still must be done.

Use of cancer antigen 125, cancer antigen 19‐9, and the neutrophil‐to‐lymphocyte ratio to diagnose mature cystic teratoma with torsion

“…A previous study found the levels of CA19‐9 and CA125 to be elevated among 39.6% and 23.3%, respectively, of patients with MCT; the levels of CA19‐9 were most likely to be raised, suggesting that this molecule is a potentially useful marker of MCT. Abnormal elevation of CA19‐9, combined with mild elevation of CA125, has been reported among patients with torsions of MCT . In the present study, the mean level of CA19‐9 in the torsion group was 404.50 U/mL, whereas the mean level of CA125 was 68.54 U/mL.…”

Mature Cystic Teratoma of Ovary with Abnormally High Levels of Ca19-9: A Case Report

“…5,10,15 Furthermore, Ca19-9 levels can be used as a marker for postoperative follow-up in benign diseases, and as a marker for recurrence of mature cystic teratomas. 4,7 In conclusion, abnormal levels of Ca19-9 are not necessarily associated with ovarian malignancy, and may lead to unnecessary medical intervention and patient anxiety. We described one case of unilateral MCT with the second highest concentration of Ca19-9 (8922.76 UI/mL) published in literature, with no signs of torsion or necrosis.…”

“…2,3 Although most women presenting MCT are asymptomatic, $ 20% can have complications such as torsion, rupture, infection and malignant transformation (0,17-3% of cases). 4,5 MCTs are composed of one or more of the three well differentiated tissues derived from the ectoderm, mesoderm and/or endoderm germ layers. This heterogeneous composition Palavras-chave ► Ca19-9 ► marcadores tumorais ► teratoma maduro cístico ► teratoma ovárico ► quisto dermoide…”

Benign cystic mediastinal teratoma presenting as a massive pleural effusion in a 17-year–old boy

“…Ca19.9 has previously been reported to be produced by mature benign cystic teratomas of the mediastinum. It is possibly secreted from the apical cytoplasm of the epithelial lining of the cyst wall 8 9…”