Unusually low prevalence of<i>Mycoplasma genitalium</i>in urine samples from infertile men and healthy controls: a prevalence study

Plečko, Vanda; Žele-Starčević, Lidija; Tripković, Vesna; Skerlev, Mihael; Ljubojević, Suzana; Pleško, Sanja; Mareković, Ivana; Jensen, Jørgen Skov

doi:10.1136/bmjopen-2014-005372

Cited by 16 publications

(10 citation statements)

References 16 publications

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“…Five of the 14 were case–control studies concerning U. urealyticum infection, with a total of 611 cases and 506 controls (Zeighami et al ., ; Zhao & Liu, ; Zeng et al ., ; Abusarah et al ., ; Zhang et al ., ). The remaining nine studies were case–control studies on M. hominis infection, totaling 2410 cases and 1223 controls (Shi & Chang, ; Pang et al ., ; Al‐Sweih et al ., ; Lee et al ., ; Zeng et al ., ; Huang et al ., ; Liu et al ., ; Plecko et al ., ; Zhang et al ., ). The other two infections ( U. parvum and M. genitalium ) were investigated in five (Zeighami et al ., ; Zhao & Liu, ; Zeng et al ., ; Abusarah et al ., ; Zhang et al ., ) and three (Al‐Sweih et al ., ; Abusarah et al ., ; Plecko et al ., ) studies, respectively.…”

Section: Resultsmentioning

confidence: 97%

Mycoplasma and ureaplasma infection and male infertility: a systematic review and meta-analysis

et al. 2015

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SUMMARYThe relationship between mycoplasma and ureaplasma infection and male infertility has been studied widely; however, results remain controversial. This meta-analysis investigated the association between genital ureaplasmas (Ureaplasma urealyticum, Ureaplasma parvum) and mycoplasmas (Mycoplasma hominis, Mycoplasma genitalium), and risk of male infertility. Differences in prevalence of ureaplasma and mycoplasma infection between China and the rest of the world were also compared. Study data were collected from PubMed, Embase and the China National Knowledge Infrastructure. Summary odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship. Heterogeneity testing and publication bias testing were also performed. A total of 14 studies were used: five case-control studies with 611 infertile cases and 506 controls featuring U. urealyticum infection, and nine case-control studies with 2410 cases and 1223 controls concerning M. hominis infection. Two other infection (U. parvum and M. genitalium) were featured in five and three studies, respectively. The meta-analysis results indicated that U. parvum and M. genitalium are not associated with male infertility. However, a significant relationship existed between U. urealyticum and M. hominis and male infertility. Comparing the global average with China, a significantly higher positive rate of U. urealyticum, but a significantly lower positive rate of M. hominis, was observed in both the infertile and control groups in China.

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Section: Resultsmentioning

confidence: 97%

Mycoplasma and ureaplasma infection and male infertility: a systematic review and meta-analysis

et al. 2015

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“…6 However, whether M. genitalium is associated with male infertility and genital tract tumors remains unclear. [7][8][9] The infection rate of M. genitalium varies depending on the source of research samples. The infection rate of a population practicing low-risk sexual behaviors is approximately 2%, while the infection rate of a population practicing high-risk sexual behaviors is approximately 7.3%.…”

Section: Introductionmentioning

confidence: 99%

“…6 However, whether M. genitalium is associated with male infertility and genital tract tumors remains unclear. 7–9…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the efficacy of moxifloxacin in treating Mycoplasma genitalium infection

et al. 2017

Int J STD AIDS

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Mycoplasma genitalium is an important pathogen that is transmitted through sexual contact. For patients diagnosed with M. genitalium infection, the current guidelines recommend 1 g of azithromycin as the first-line treatment. Moxifloxacin is used as a second-line drug due to its remarkable efficacy; however, increased use of moxifloxacin to treat M. genitalium infections has caused the emergence of cases of moxifloxacin treatment failure. This meta-analysis aims to estimate the treatment efficacy of moxifloxacin for M. genitalium infection. Electronic databases were searched for articles published from 1983 to the end of May 2016 using the following search terms: ( Mycoplasma genitalium) AND (moxifloxacin OR 1-cyclopropyl-7-(2,8-diazabicyclo(4.3.0)non-8-yl)-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinoline carboxylic acid OR Proflox OR moxifloxacin hydrochloride OR Octegra OR Avelox OR Avalox OR Izilox OR Actira OR [treatment efficacy]). All included studies were published in English; all participants were diagnosed with M. genitalium infection, and microbial cure times were measured within 12 months after treatment. Treatment efficacy was measured as microbial cure at the final follow-up after treatment. In total, 17 studies including 252 participants met the inclusion criteria. The majority of these studies were observational. The random-effects pooled microbial cure rate was 96% (95% confidence interval [CI], 90%-99%; I= 28.59%, P = 0.13). For studies with sample collection deadlines prior to 2010, the pooled microbial cure rate was 100% (95% CI, 99%-100%; I= 0.00%, P = 1.00). For studies with sample collection deadlines of 2010 and later, the pooled microbial cure rate was 89% (95% CI, 82%-94%; I= 0.00%, P = 0.59). The elimination rate of moxifloxacin for M. genitalium infection has decreased from 100% to 89% since 2010. This decline merits considerable attention. We suggest close follow-up to investigate the efficacy of moxifloxacin for treating M. genitalium infections. Additionally, sentinel points should be established to detect mutations in the gyrA/B and parC/E genes, which are associated with moxifloxacin resistance.

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“…[ 1 ] It is considered as an independent risk factor for cervicitis in women, but its role in pelvic inflammatory disease, spontaneous abortion and infertility has not been ascertained until recently. [ 2 3 ] The prevalence of M. genitalium in women ranges from <1% to 42%,[ 4 5 ] depending on whether we consider low-risk population (i.e., attendees of general practitioners and public health services) or high-risk population (i.e., sexually transmitted disease clinics attendees or those with specific symptoms).…”

Section: Introductionmentioning

confidence: 99%

“…Only one study regarding M. genitalium prevalence in Croatia was published thus far, conducted in men attending fertility clinic. [ 5 ]…”

Section: Introductionmentioning

confidence: 99%

Assessing the need for routine screening for Mycoplasma genitalium in the low-risk female population: A prevalence and co-infection study on women from Croatia

Ljubin‐Sternak

Meštrović²,

Kolarić

et al. 2017

Int J Prev Med

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Background:There is an ongoing debate regarding possible cost and benefits, but also harm of universal screening for the emerging sexually transmitted pathogen Mycoplasma genitalium.Methods:From the initial pool of 8665 samples that were tested, a subset of Chlamydia trachomatis-positive and randomly selected C. trachomatis-negative cervical swabs were further interrogated for M. genitalium by real-time polymerase chain reaction, using a 224 bp long fragment of the glyceraldehyde-3-phosphate dehydrogenase gene.Results:M. genitalium was detected in 4.8% of C. trachomatis-positive samples and none of C. trachomatis-negative samples. Accordingly, a significant association was shown between M. genitalium and C. trachomatis (P < 0.01), but also between M. genitalium and Mycoplasma hominis infection (P < 0.01).Conclusions:Based on the results, routine screening is recommended only for women with one or more identified risk factors. Moreover, younger age does not represent an appropriate inclusion/exclusion criterion for M. genitalium testing in the low-risk female population.

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Unusually low prevalence ofMycoplasma genitaliumin urine samples from infertile men and healthy controls: a prevalence study

Cited by 16 publications

References 16 publications

Mycoplasma and ureaplasma infection and male infertility: a systematic review and meta-analysis

Mycoplasma and ureaplasma infection and male infertility: a systematic review and meta-analysis

Meta-analysis of the efficacy of moxifloxacin in treating Mycoplasma genitalium infection

Assessing the need for routine screening for Mycoplasma genitalium in the low-risk female population: A prevalence and co-infection study on women from Croatia

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