2024
DOI: 10.1101/2024.05.10.593314
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Unveiling Gene Perturbation Effects through Gene Regulatory Networks Inference from single-cell transcriptomic data

Clelia Corridori,
Merrit Romeike,
Giorgio Nicoletti
et al.

Abstract: Physiological and pathological processes are governed by a network of genes called gene regulatory networks (GRNs). By reconstructing GRNs, we can accurately model how cells behave in their natural state and predict how genetic changes will affect them. Transcriptomic data of single cells are now available for a wide range of cellular processes in multiple species. Thus, a method building predictive GRNs from single-cell RNA sequencing (scRNA-seq) data, without any additional prior knowledge, could have a grea… Show more

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