Unveiling Specific Triggers and Precipitating Factors for Fatal Cardiac Events in Inherited Arrhythmia Syndromes

Nakajima, Tadashi; Kaneko, Yoshiaki; Kurabayashi, Masahiko

doi:10.1253/circj.cj-15-0322

Cited by 23 publications

(22 citation statements)

References 77 publications

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“…Electrophysiologic evidence supports our findings and suggests that azithromycin lacks arrhythmogenic potential at therapeutic doses. 31,32 Fever itself may be a risk factor for arrhythmia, and therefore confounding by indication is pronounced when antibiotics are used in patients with high fever.…”

Section: Discussionmentioning

confidence: 99%

Use of azithromycin and risk of ventricular arrhythmia

Trifirò

Ridder

Sultana

et al. 2017

CMAJ

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A zithromycin is a widely prescribed broad-spectrum macrolide used mainly for the treatment of respiratory and urinary tract bacterial infections. Concerns have been raised recently regarding its arrhythmogenic potential, a risk already known to be associated with the first marketed macrolide, erythromycin.1-6 Several case reports have described QTinterval prolongation, 7-9 torsades de pointes 10-12 and polymorphic ventricular tachycardia 13 following use of azithromycin. Many observational studies have reported conflicting results about the association between azithromycin use and cardiovascular death.14-21 Because the known azithromycin-related cardiac events are related to QT-interval prolongation, torsades de pointes and ventricular arrhythmia, 18,19 these observational studies are limited by the broad category of cardiovascular death used as an outcome, which likely only partially captured cardiac risk associated with azithromycin use. To date, only 1 observational study has investigated the association between azithromycin use and ventricular arrhythmia specifically. 22Given the conflicting findings regarding this widely used antibiotic and the lack of data on ventricular arrhythmia specifically, we aimed to quantify the association between azithromycin use and the risk of ventricular arrhythmia using data from a network of 7 health care databases from 5 European countries. Methods Study design and settingWe conducted a nested case-control study within a cohort of new antibiotic users identified from a network of 7 populationbased health care databases in 5 European countries that partic- ABSTRACT BACKGROUND: There are conflicting findings from observational studies of the arrhythrogenic potential of azithromycin. Our aim was to quantify the association between azithromycin use and the risk of ventricular arrhythmia. RESEARCH Use of azithromycin and risk of ventricular arrhythmia

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Section: Discussionmentioning

confidence: 99%

Use of azithromycin and risk of ventricular arrhythmia

Trifirò

Ridder

Sultana

et al. 2017

CMAJ

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“…31 This arrhythmogenic substrate may be caused by structural and electrical remodeling. 32, 33 Although pericardial fat is a risk factor for changes in the thickness and function of cardiac muscles, no significant differences in LV or RV wall thickness were found between the VPB groups in this study ( Table 1). This may be related to the distinctive population in this study, because most of the study individuals were relatively healthy.…”

Section: Discussionmentioning

confidence: 59%

Pericardial Fat Is Associated With the Risk of Ventricular Arrhythmia in Asian Patients

Tam

Lin

Chan

et al. 2016

Circ J

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“…1 Genes that regulate the expression levels and function of ion channels can cause arrhythmia syndromes. Mutations in GPD1-L decrease sodium channel expression and are causative for BrS, in which one of the important mechanisms is decreased sodium currents.…”

Section: Article P 2435mentioning

confidence: 99%

“…13 Among patients with idiopathic ventricular fibrillation, a mutation in ANK2 ultiple causative genes for various inherited arrhythmia syndromes have been identified. 1 Most of the genes encode ion channels and some genes are responsible for multiple arrhythmia syndromes because they are critical for normal cardiac function, especially cardiac electrophysiological activity. For example, sodium channels play an important role in the generation and propagation of electrical signals in the heart, and SCN5A encoding the predominant cardiac sodium channel α subunit is causative for various arrhythmia syndromes, including sinus node dysfunction, atrioventricular block, atrial fibrillation, long QT (LQT) syndrome, and Brugada syndrome (BrS).…”

mentioning

confidence: 99%