2024
DOI: 10.2478/acph-2024-0033
|View full text |Cite
|
Sign up to set email alerts
|

Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids

Goran Poje,
Davor Šakić,
Marina Marinović
et al.

Abstract: The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise harmine/β-carboline and ferrocene moiety, we investigated their antiglioblastoma potential in vitro and mechanism of action (inhibition of DYRK1A, Hsp90, anti-oxidative activity). The results have shown that triazole-type harmicens, namely 5, with a ferrocene moiety in C-3 p… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
references
References 44 publications
0
0
0
Order By: Relevance