Unveiling the chemistry of 1,3,4‐oxadiazoles and thiadiazols: A comprehensive review

Abstract

Oxadiazoles and thiadiazoles are malleable heterocycles that have recently generated major interest in the field of medicinal chemistry. Compounds based on these moieties have versatile biological applications such as anticonvulsant, anticancer, antidiabetic, and antioxidant agents. Due to the versatile nature and stability of the oxadiazole and thiadiazole nucleus, medicinal chemists have changed the structural elements of the ring in numerous ways. These compounds have shown significant anticonvulsant effects, demonstrating their potential in the management of epileptic disorders. In this review, we have covered numerous biological pathways and in silico targeted proteins of oxadiazole and thiadiazole derivatives for treating various biological disorders. The data compiled in this article will be helpful for researchers, research scientists, and research chemists who work in the field of drug discovery and drug development.

Design, Synthesis, and Mode of Action of Thioacetamide Derivatives as the Algicide Candidate Based on Active Substructure Splicing Strategy

“…A quantity of studies had been widely used to find efficient molecular structures as potential algicides. − The 1,3,4-thiadiazole/oxadiazole/triazole skeleton has been favored by researchers because of its biological activities with a series of different abilities, such as antibacterial, antiviral, analgesic, antipsychotic, antiallergic, antitumor, and anti-inflammatory . In particular, the recent literature showed that the heterocyclic compounds containing phenyl substituents had significant anti-insect and antibacterial activities (Figure A). − Based on these good results, we have carried out an in-depth study on the algicidal effect of phenyl substituted heterocyclic modified molecules in order to find new and efficient algicidal agents and open up a new way for bioactive substrates.…”

“…A quantity of studies had been widely used to find efficient molecular structures as potential algicides. 21 thiadiazole/oxadiazole/triazole skeleton has been favored by researchers because of its biological activities with a series of different abilities, such as antibacterial, 24 antiviral, 25 analgesic, 26 antipsychotic, 27 antiallergic, 28 antitumor, 29 and antiinflammatory. 30 In particular, the recent literature showed that the heterocyclic compounds containing phenyl substituents had significant anti-insect and antibacterial activities (Figure 1A).…”

BSA Binding and Aggregate Formation of a Synthetic Amino Acid with Potential for Promoting Fibroblast Proliferation: An In Silico, CD Spectroscopic, DLS, and Cellular Study

“…In the realm of drug discovery and development, several compounds incorporating an oxadiazole component are undergoing advanced clinical trials, such as Zibotentan, which exhibits anticancer properties [13,14]. Of the isomeric forms, particular attention is focused on 1,3,4-oxadiazoles [15] due to their significant relevance across diverse scientific domains, including the pharmaceutical industry, drug discovery efforts, the production of scintillating materials, and the dyestuff industry [16]. The inherent structural diversity and synthetic accessibility of oxadiazoles make them attractive candidates for the design of novel therapeutic agents with enhanced biological activities and improved pharmacokinetic profiles.…”