Unveiling the Cleavage Mechanism of an RNA Model Compound on the whole pH Scale: Computations Meet Experiments in the Determination of Reaction Rates
Alessandro Nicola Nardi,
Alessio Olivieri,
Marco D'Abramo
et al.
Abstract:The knowledge of the mechanism of reactions occurring in solution is a primary research line both in the context of theoretical‐computational chemistry and in the field of organic and bio‐organic chemistry. Given the importance of the hydrolysis of nucleic acids in life‐related phenomena, here we present a combined experimental and computational study on the cleavage of an RNA model compound. This phosphodiester features a cleavage rate strictly dependent on the pH with three different dependence domains. Such… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.