Unveiling the critical roles of cellular metabolism suppression in antibiotic tolerance
Sayed Golam Mohiuddin,
Han Ngo,
Mehmet A. Orman
Abstract:Metabolic inhibitors are known to exhibit complex interactions with antibiotics in bacteria, potentially acting as antagonists by inducing cell dormancy and promoting cell survival. However, the specific synergistic or antagonistic effects of these inhibitors depend on factors like their mechanisms of action, concentrations, and treatment timings, which require further investigation. In our study, we systematically explored the synergistic interactions of various metabolic inhibitors—such as chloramphenicol (a… Show more
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