Unveiling the Intricacies of Helicobacter pylori-Induced Gastric Inflammation: T Helper Cells and Matrix Metalloproteinases at a Crossroad

Banerjee, Avisek; Mukhopadhyay, Asish K.; Paul, Surojit; Bhattacharyya, Arindam; Swarnakar, Snehasikta

doi:10.5772/54193

Cited by 9 publications

(9 citation statements)

References 206 publications

(171 reference statements)

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“…Bacterial virulence factors and the host immune system both play crucial roles in the pathological progression and outcome of GC cases [8,9]. Interactions between bacterial and microenvironment factors and host innate and adaptive immune responses result in inflammation and ultimately gastric carcinoma [7,10]. Both the innate and adaptive immune responses can inhibit the progression of carcinogenic processes and tumor cell development [10].…”

Section: Introductionmentioning

confidence: 99%

“…Interactions between bacterial and microenvironment factors and host innate and adaptive immune responses result in inflammation and ultimately gastric carcinoma [7,10]. Both the innate and adaptive immune responses can inhibit the progression of carcinogenic processes and tumor cell development [10]. The adaptive immune response is mediated mainly by T cells including T helper (Th) 1, Th2, Th17, and regulatory T (Treg) cells.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of thymic stromal lymphopoietin (TSLP) and its correlation with lymphatic metastasis in human gastric cancer

et al. 2015

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Thymic stromal lymphopoietin (TSLP) is an IL-7-like type 1 inflammatory cytokine that is mainly produced by epithelial cells in the skin, lungs, thymus, and gastrointestinal tract. This cytokine is a master regulator involved in T helper 2 cell-type inflammation immune responses. Various cell types, including T, B, mast, dendritic, and cancer or cancer-associated cells, are activated via TSLP. TSLP expression is also associated with various human cancers and produced by Helicobacter pylori-infected human gastric epithelial cells. TSLP is a multi-functional protein that can act as both an oncogene and a tumor suppressor. The aim of this study was to examine the role of TSLP in the progression of gastric cancer (GC) and its correlation with clinicopathological features in GC patients. Because of the relationship between H. p ylori infection and GC, we also examined gastric tissue specimens for H. p ylori DNA. In this study, fresh tumoral tissues and distant tumor-free samples from 50 GC patients were assessed for TSLP mRNA expression by quantitative real-time PCR. The GC samples were also assessed for H. p ylori DNA using primers specific for H. p ylori 16S rRNA and the UreC genes by PCR. TSLP mRNA was overexpressed in 20 of the 50 (40%) GC samples relative to their corresponding normal tissues. TSLP overexpression was significantly correlated with tumor cell metastasis to lymph nodes. Of the 20 patients with TSLP overexpression, 17 (85.0%) had metastasis to lymph nodes (p = 0.023). In addition, the presence of H. p ylori was confirmed by PCR in 22 of the 50 (44%) cases and 10 (50%) of the 20 TSLP overexpressors. We show that human GC cells produce TSLP and a significant correlation was seen between TSLP overexpression and GC metastasis to lymph nodes. This is the first report to indicate that TSLP may play a role in lymph node involvement in GC patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of thymic stromal lymphopoietin (TSLP) and its correlation with lymphatic metastasis in human gastric cancer

et al. 2015

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“…17 In vivo and in vitro studies showed an increase in interleukin-8 levels associated with H. pylori infection on which the induction of interleukin-8 expression was mediated through NF-κB and protein activator-1 (AP-1). 18,19 H. pylori will directly upregulate the expression of messenger RNA from Interleukin-8 and Interleukin-8 protein in epithelial cells. [20][21][22][23] The H. pylori strain expresses three virulence factors.…”

Section: Discussionmentioning

confidence: 99%

The Relationship of Interleukin-8 Levels in Childrens Gastritis with and without Helicobacter Pylori Infections

María¹,

Supriatmo²,

Ramayani³

et al. 2020

IJRP

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“…Also varied based on where they lived, such as low to middle income and industrialized countries. A study in Bangladesh reported 42% H. pylori prevalence in children aged 2 years old and the rate increased rapidly to 67% with 10 years old children (Banerjee, 2013). In Jakarta, Indonesia, the prevalence of H. pylori infection was 27% based on the serological testing done to 150 elementary school students, where 90% of them were seropositive for H. pylori in their stomaches (Hegar, 2000).…”

Section: Introductionmentioning

confidence: 99%

Correlation between Absolute Neutrophil Count Level and Helicobacter Pylori Infection in Pediatric Gastritis

Claudia¹,

Supriatmo²,

Lubis³

2021

IJRP

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Helicobacter pylori infection is the most common cause of gastritis worldwide and associated with gastric ulcer and cancer. There are not many studies assessing the significance of baseline and clinical characteristics, and absolute neutrophil count (ANC) in H. pylori associated gastritis. This study assessed the correlation between both baseline and clinical characteristics and ANC in pediatric H. pylori associated gastritis. An analytical cross sectional research was conducted in Haji Adam Malik and Universitas Sumatera Utara hospitals between October -December 2020. Research subjects were pediatric patients with gastritis. They underwent H. pylori screening and ANC test. Independent t-test and Mann-Whitney test were used to assess the correlation. From 82 research subjects, 45 subjects were positive H. pylori and 37 subjects were negative. Demographic data, such as age, gender, ethnicity, socioeconomic status, level of education of children and parents, and parents' occupation, was not significantly correlated to H. pylori infection. Clinical data, such as body height and weight, nutritional status, and symptoms, was not significantly correlated to H. pylori infection. There was no significant difference between ANC and H. pylori infection in the two groups. There were no significant differences in baseline and clinical characteristic data and ANC with pediatric H. pylori gastritis.

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Unveiling the Intricacies of Helicobacter pylori-Induced Gastric Inflammation: T Helper Cells and Matrix Metalloproteinases at a Crossroad

Cited by 9 publications

References 206 publications

Evaluation of thymic stromal lymphopoietin (TSLP) and its correlation with lymphatic metastasis in human gastric cancer

Evaluation of thymic stromal lymphopoietin (TSLP) and its correlation with lymphatic metastasis in human gastric cancer

The Relationship of Interleukin-8 Levels in Childrens Gastritis with and without Helicobacter Pylori Infections

Correlation between Absolute Neutrophil Count Level and Helicobacter Pylori Infection in Pediatric Gastritis

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