Unveiling the mechanism and origin of stereocontrol in dinuclear-zinc-catalyzed reductive desymmetrization of malonic esters

Abstract

The recently described reductive desymmetrization of malonic esters enabled by a dinuclear zinc complex with a chiral tetradentate ligand provides an efficient method for the formation of all-carbon quaternary stereocentres....

Theoretical evidence for the enantioselectivity of Mannich reactions with fluorinated aromatic ketones

“…As asymmetric synthesis strategies have been widely used, mechanistic studies of these asymmetric strategies catalyzed by organometallic catalysts 15 or by organocatalysts 16 have attracted considerable interest. In 2017, we reported a mechanism for the asymmetric ring-opening reaction of oxabicyclic alkenes catalyzed by a rhodium/Josiphos transition metal.…”