2024
DOI: 10.1093/pnasnexus/pgae316
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Unveiling the molecular mechanisms of the type IX secretion system's response regulator: Structural and functional insights

Anshu Saran,
Hey-Min Kim,
Ireland Manning
et al.

Abstract: The Type-IX secretion system (T9SS) is a nanomachinery utilized by bacterial pathogens to facilitate infection. The system is regulated by a signaling cascade serving as its activation switch. A pivotal member in this cascade, the response regulator protein PorX, represents a promising drug target to prevent the secretion of virulence factors. Here, we provide a comprehensive characterization of PorX both in vitro and in vivo. First, our structural studies revealed PorX harbours a unique enzymatic effector dom… Show more

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