2024
DOI: 10.21203/rs.3.rs-4406946/v1
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Unveiling the Mystery: Investigating the Debate Surrounding Helicobacter pylori Infection and Multiple Sclerosis Using Mendelian Randomization Analysis

Jie Zhou,
Dagang Zhu,
Yixin Xu
et al.

Abstract: Background Many studies have explored the association between Helicobacter pylori (H. pylori) infection and multiple sclerosis (MS), but there is significant controversy in the results, and a unified conclusion has not yet been reached. Methods In order to calculate the causal relationship between H. pylori and MS, we employed a two-sample bidirectional Mendelian randomization (MR) analysis. Genetic instruments for MS from FinnGen were used as the training cohort, and the MS dataset from the International Mult… Show more

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