Unveiling the Pharmacological and Nanotechnological Facets of Daidzein: Present State-of-the-Art and Future Perspectives

Abstract

Herbal drugs have been attracting much scientific interest in the last few decades and nowadays, phytoconstituents-based research is in progress to disclose their unidentified medicinal potential. Daidzein (DAI) is the natural phytoestrogen isoflavone derived primarily from leguminous plants, such as the soybean and mung bean, and its IUPAC name is 4′,7-dihydroxyisoflavone. This compound has received great attention as a fascinating pharmacophore with remarkable potential for the therapeutic management of several diseases. Certain pharmacokinetic properties of DAI such as less aqueous solubility, low permeability, and poor bioavailability are major obstacles restricting the therapeutic applications. In this review, distinctive physicochemical characteristics and pharmacokinetics of DAI has been elucidated. The pharmacological applications in treatment of several disorders like oxidative stress, cancer, obesity, cardiovascular, neuroprotective, diabetes, ovariectomy, anxiety, and inflammation with their mechanism of action are explained. Furthermore, this review article comprehensively focuses to provide up-to-date information about nanotechnology-based formulations which have been investigated for DAI in preceding years which includes polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carrier, polymer-lipid nanoparticles, nanocomplexes, polymeric micelles, nanoemulsion, nanosuspension, liposomes, and self-microemulsifying drug delivery systems.

Supplementation of Saussurea costus root alleviates sodium nitrite-induced hepatorenal toxicity by modulating metabolic profile, inflammation, and apoptosis

“…The observed anti-inflammatory and anti-apoptotic potential of SCREE could be associated with the detected set of metabolites, including apigenin, apigenin-7-O-glucoside, luteolin, daidzein, acacetin and formononetin. The improvement in apoptotic and inflammatory markers could be attributed to the presence of daidzein and apigenin in SCREE, which play a crucial role in the regulation of tumor cell invasion (Singh et al, 2023). Daidzein exerts its anti-inflammatory effects by downregulating TNF-α expression by inhibiting the nuclear factor-kappa B (NF-κB) signaling pathway.…”

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

“… Isoflavones —represented mainly by genistein and daidzein, found in soybeans ( Glycine max ) and mung beans ( Vigna radiata ). Both are a TD with lipid nanocarriers [ 198 , 199 ]. …”

The Use of Essential Oils in Acne Vulgaris Updated Analysis of the Web of Science Literature Landscape

“…Medicinal herbs have a lengthy history of utilization and have been demonstrated to have minimal adverse effects. In addition to common illnesses such as colds and infectious illnesses, they have been effective in preventing and treating an extensive variety of diseases 11,12 .…”