Unveiling the Significance of Peroxiredoxin 6 in Central Nervous System Disorders

Xue, Min; Huang, Xiaojie; Zhu, Tong; Zhang, Lijun; Yang, Hao; Shen, Yuxian; Feng, Lijie

doi:10.3390/antiox13040449

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article4

Preprint1

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Multifaceted in-vitro and in-silico evaluation of Pimenta racemosa (Mill.) essential oil: A potential alternative source of eugenol

Gogoi,

Jayaprakash,

Tamang

et al. 2025

Industrial Crops and Products

View full text Add to dashboard Cite

Multifaceted in-vitro and in-silico evaluation of Pimenta racemosa (Mill.) essential oil: A potential alternative source of eugenol

Gogoi,

Jayaprakash,

Tamang

et al. 2025

Industrial Crops and Products

View full text Add to dashboard Cite

Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelines

Zhang,

Xu,

Jiang

et al. 2024

Preprint

View full text Add to dashboard Cite

Cellular senescence is a cell fate triggered by inherent or environmental stress and characterized by stable cell cycle arrest accompanied by a hypersecretory feature, termed as the senescence-associated secretory phenotype (SASP). Senescent cell burden increases with natural aging, functionally contributing to age-related organ dysfunction and multiple disorders. In this study, we performed a large scale screening of a natural product library for senotherapeutic candidates by assessing their effects on human senescent cells. Apigenin, a dietary flavonoid previously reported with antioxidant and anti-inflammatory activities, exhibited a prominent capacity in targeting senescent cells as a senomorphic agent. In senescent cells, apigenin blocks the interactions between ATM/p38 and HSPA8, thus preventing transition of the acute stress-associated phenotype (ASAP) towards the SASP. Mechanistically, apigenin targets peroxiredoxin 6 (PRDX6), an intracellular redox-active molecule, suppressing the iPLA2 activity of PRDX6 and disrupting downstream reactions underlying the SASP development. Without reversing cellular senescence, apigenin deprives cancer cells of malignancy acquired from senescent stromal cells in culture, while reducing chemoresistance upon combination with chemotherapy in anticancer regimens. In preclinical trials, apigenin administration improves physical function of animals prematurely aged after whole body irradiation, alleviating physical frailty and cognitive impairment. Overall, our study demonstrates the potential of exploiting a naturally derived compound with senomorphic capacity to achieve geroprotective effects by modulating the SASP, thus providing a research platform for future exploration of novel natural agents against age-related conditions.

show abstract

Inhibition of Oxidative Stress and Related Signaling Pathways in Neuroprotection

Jembrek

2024

Antioxidants

View full text Add to dashboard Cite

show abstract

Unveiling the Significance of Peroxiredoxin 6 in Central Nervous System Disorders

Cited by 5 publications

References 120 publications

Multifaceted in-vitro and in-silico evaluation of Pimenta racemosa (Mill.) essential oil: A potential alternative source of eugenol

Multifaceted in-vitro and in-silico evaluation of Pimenta racemosa (Mill.) essential oil: A potential alternative source of eugenol

Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelines

Inhibition of Oxidative Stress and Related Signaling Pathways in Neuroprotection

Contact Info

Product

Resources

About