Unveiling the Uncommon: Co-occurrence of Drug-Induced Liver Injury and Erythema Multiforme Following Cefazolin Administration

Abstract

Adverse drug reactions have a wide variety of manifestations including allergic reactions, anaphylaxis, skin rashes, liver or kidney injury, and gastrointestinal disturbances. Erythema multiforme (EM) and Drug induced Liver injury (DILI) represent significant outcomes of adverse drug reactions. We present a unique case of a 21-year-old female who experienced co-occurrence of EM and DILI following antibiotic administration, an observation which has not been reported before. This case highlights the potential for patients to develop multiorgan involvement in adverse drug reactions. Recognition of such adverse effects is crucial for timely diagnosis, management, and the prevention of unnecessary testing, invasive procedures, and associated complications.