Unveiling thiol biomarkers: Glutathione and cysteamine

Gopika, M.G.; Gopidas, Surya; Jayan, Gokul S.; Arathy, P.S.; Saraswathyamma, Beena

doi:10.1016/j.cca.2024.119915

Clinica Chimica Acta

2024

DOI: 10.1016/j.cca.2024.119915

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Unveiling thiol biomarkers: Glutathione and cysteamine

M.G. Gopika,

Surya Gopidas,

Gokul S. Jayan

et al.

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2024

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Cited by 2 publications

References 156 publications

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Developing dual detection platforms for the electrochemical quantification of homocysteine in biological samples

Gopika,

Govindasamy,

Saraswathyamma

2024

Microchemical Journal

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Developing dual detection platforms for the electrochemical quantification of homocysteine in biological samples

Gopika,

Govindasamy,

Saraswathyamma

2024

Microchemical Journal

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β-Cyclodextrin Functionalized Au@Ag Core-Shell Nanoparticles: Plasmonic Sensors for Cysteamine and Efficient Nanocatalysts for Nitrobenzene-to-Aniline Conversion

Rajamanikandan,

Sasikumar,

2024

Biosensors

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We reported the gold/silver core-shell nanoparticles (Aucore@Agshell NPs) functionalized with β-cyclodextrin (β-CD) as versatile nano-agents demonstrated for human urine-based biosensing of cysteamine and catalytic conversion from nitrobenzene (NB) to aniline. First, the hybrid bimetallic nanoparticles, i.e., β-CD-Aucore@Agshell NPs, constituted a colorimetric sensing platform based on localized surface plasmons, enabling cysteamine (Cyst) to be detected in a remarkably rapid manner, i.e., within 2 min, which was greatly shortened in comparison with that of our previous report. This was due largely to use of β-CD being effectively replaceable by Cyst. The detection of Cyst was demonstrated using human urine specimens in the linear range of 25–750 nM with a limit of detection of 1.83 nM. Excellent specificity in detecting Cyst was also demonstrated against potential interfering molecules. Meanwhile, the β-CD-Aucore@Agshell NPs were demonstrated as nanocatalysts for converting NB to aniline with efficiency enhanced by more than three-fold over the pure gold nanoparticles previously reported, due to the dual functions of the structural core-shell. The demonstrated versatile features of the hybrid nanoparticles can find applications in human urine-based biosensors for Cyst detection, and in the screening of Cyst-containing drugs, while detoxicating NB for ecological protection in aqueous media.

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Unveiling thiol biomarkers: Glutathione and cysteamine

Cited by 2 publications

References 156 publications

Developing dual detection platforms for the electrochemical quantification of homocysteine in biological samples

Developing dual detection platforms for the electrochemical quantification of homocysteine in biological samples

β-Cyclodextrin Functionalized Au@Ag Core-Shell Nanoparticles: Plasmonic Sensors for Cysteamine and Efficient Nanocatalysts for Nitrobenzene-to-Aniline Conversion

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