Up-Conversion Nanosized Phosphors Based Fluoride for Photodynamic Therapy of Malignant Tumors

Dorokhina, Anastasiya M.; Bakhmetyev, Vadim V.

doi:10.1007/978-3-319-99834-3_16

Cited by 1 publication

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hydrothermal synthesis is known as a relatively simple and inexpensive method that privides finely dispersed particles. Earlier, using the hydrothermal technique, we synthesized nanosized phosphors based on mixed fluorides [20,21]. The aim of this work was to obtain Y2O3:Eu phosphors by the hydrothermal method and study their properties.…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Y2O3: Eu Nanosized Phosphor Using Hydrothermal Technique and Rapid Thermal Annealing (RTA)

Vlasenko

Bakhmetyev

2020

KEM

Self Cite

View full text Add to dashboard Cite

The application of special nanomaterials is promising for the development of new methods for the diagnostics and treatment of cancer. Photodynamic therapy (PDT) is a well-known and recognized method of cancer treatment. This type of therapy is less carcinogenic and mutagenic compared to radiation and chemotherapy, since the applied photosensitizers do not bind to DNA of the cells. However, currently this technique is only applicable to skin cancer, while its extension to the treatment of abdominal tumors requires the creation of pharmacological drugs for PDT, which along with a photosensitizer include a colloidal solution of nanosized luminescent phosphor emitting visible light with the required wavelength under the influence of infrared, X-ray or γ-radiation, which easily penetrates the body tissues. Since photosensitizers are already available as commercial products, the most important goal is the development of nanosized phosphors providing the required radiation convertion. In this study, the effects of hydrothermal synthesis, duration and the conditions of rapid thermal annealing (RTA) on Y2O3:Eu phosphor particle size were studied. The hydrothermal synthesis technique was carried out in two ways: chloride (precipitation from a chloride solution using NaOH and NH4OH precipitators) and acetate (decomposition of mixed acetate either without a dispersant at 230° C for 24 hours, or using PEG-200 and PEG-2000 as dispersants at 230 °C for 12 hours). The rapid thermal annealing was performed either at 600 °C for 20 minutes, or at 800 °C for 5 minutes. The developed synthetic approaches afforded Y2O3:Eu nanosized phosphor samples with the particle size not exceeding 200 nm.

show abstract

Section: Methodsmentioning

confidence: 99%