Up-regulated lncRNA-MSX2P1 promotes the growth of IL-22-stimulated keratinocytes by inhibiting miR-6731-5p and activating S100A7

Qiao, Meng; Li, Ronghua; Zhao, Xintong; Yan, Jianjun; Sun, Qing

doi:10.1016/j.yexcr.2018.01.014

Cited by 55 publications

(56 citation statements)

References 40 publications

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“…For instance, MEG3/miR-21 axis contribute in the pathophysiology of psoriasis through modulation of caspase-8, cleaved caspase-8, cytc, and apaf-1 [ 14 ]. Moreover, expression studies in IL-22-stimulated keratinocytes have shown the role of the MSX2P1-miR-6731-5p axis in the regulation of S100A7 [ 19 ]. Such lncRNA/miRNA/mRNA trios are putative therapeutic targets in psoriasis.…”

Section: Discussionmentioning

confidence: 99%

“… Keratinocytes, HaCaT and HNEK cells miR-6731-5p and S100A7 MSX2P1 acts as an endogenous sponge directly binding to miR-6731-5p and thus, resulting in elevated levels of S100A7 and other proinflammatory cytokines, by suppressing the expression of miR-6731-5p and inducing apoptosis in IL-22-stimulated keratinocytes. [ 19 ] SLC6A14-1:1 15 patients with psoriasis and 15 healthy controls were recruited. Skin samples Differentiation and function of Treg cells, NF-κΒ, mTOR, MAPK and JAK-STAT signaling pathway and the release of cytokines and chemokines The mentioned lncRNAs may be used as potential biomarkers and therapeutic targets for the treatment of psoriasis.…”

Section: Lncrnas and Psoriasismentioning

confidence: 99%

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The eminent roles of ncRNAs in the pathogenesis of psoriasis

Ghafouri‐Fard

Eghtedarian

Taheri

et al. 2020

Non-coding RNA Research

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Psoriasis is a chronic immune-related disorder in which both genetic and environmental parameters are involved. Recent studies have demonstrated dysregulation of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the peripheral blood or skin lesions of patients with psoriasis. While a number of lncRNAs such as MEG3, AL162231.4 and NONHSAT044111 have been down-regulated in the course of psoriasis, others including PRINS, MIR31HG, RP6‐65G23.1, MSX2P1, SLC6A14-1:1, NR_003062 have been up-regulated. Moreover, expressions of several miRNAs have been dysregulated in this disorder. Among dysregulated miRNAs are miR-126, miR-143, miR-19a and miR-155 whose diagnostic roles in the psoriasis have also been assessed. Dysregulated non-coding RNAs in this disorder participate in the regulation of chemokine signaling pathway and immune response, control of epidermal development and skin barrier as well as modulation of function of certain subsets of T cells. Besides, these transcripts possibly regulate activity of NF-κΒ, mTOR, MAPK and JAK-STAT signaling pathways. Besides, expression levels of circRNAs have been decreased in the psoriasis lesions. Massive alterations in the levels of lncRNAs and miRNAs in the psoriasis lesions or peripheral blood of affected individuals show participation of these transcripts in the pathogenesis of this disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Lncrnas and Psoriasismentioning

confidence: 99%

The eminent roles of ncRNAs in the pathogenesis of psoriasis

Ghafouri‐Fard

Eghtedarian

Taheri

et al. 2020

Non-coding RNA Research

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“…Recently, Qiao et al [ 93 ] have suggested that the other cytoplasmic lncRNA – Msh homeobox 2 pseudogene 1 (MSX2P1) was upregulated in psoriatic lesions compared with normal healthy skin tissues, human immortalized keratinocyte cells and normal human epidermal keratinocyte cells. LncRNA MSX2P1 facilitated the progression and growth of IL-22-stimulated keratinocytes by serving as an endogenous sponge directly binding to miR-6731-5p and activating S100A7.…”

Section: Long Non-coding Rna In Psoriasismentioning

confidence: 99%

Pathogenesis of psoriasis in the “omic” era. Part II. Genetic, genomic and epigenetic changes in psoriasis

Nedoszytko¹,

Szczerkowska‐Dobosz²,

Stawczyk-Macieja³

et al. 2020

pdia

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Psoriasis is a multifactorial disease in which genetic, environmental and epigenetic factors regulating gene expression play a key role. In the “genomic era”, genome-wide association studies together with target genotyping platforms performed in different ethnic populations have found more than 50 genetic susceptible markers associated with the risk of psoriasis which have been identified so far. Up till now, the strongest association with the risk of the disease has been proved for HLA-C*06 gene. The majority of other psoriasis risk SNPs are situated near the genes encoding molecules involved in adaptive and innate immunity, and skin barrier function. Many contemporary studies indicate that the epigenetic changes: histone modification, promoter methylations, long non-coding and micro-RNA hyperexpression are considered as factors contributing to psoriasis pathogenesis as they regulate abnormal keratinocyte differentiation and proliferation, aberrant keratinocytes – inflammatory cells communication, neoangiogenesis and chronic inflammation. The circulating miRNAs detected in the blood may become specific markers in the diagnosis, prognosis and response to the treatment of the disease. The inhibition of expression in selected miRNAs may be a new promising therapy option for patients with psoriasis.

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“…S100A7 is also known as psoriasin, which is increased in epidermal hyperproliferative disorders [103]. Downregulation of miR-6731-5p activates S100A7, which is involved in IL-22-stimulated keratinocyte proliferation [96].…”

Section: S100 and Its Transcription Factorsmentioning

confidence: 99%

The Role of MicroRNAs in Epidermal Barrier

Lee

2020

IJMS

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MicroRNAs (miRNAs), which mostly cause target gene silencing via transcriptional repression and degradation of target mRNAs, regulate a plethora of cellular activities, such as cell growth, differentiation, development, and apoptosis. In the case of skin keratinocytes, the role of miRNA in epidermal barrier integrity has been identified. Based on the impact of key genetic and environmental factors on the integrity and maintenance of skin barrier, the association of miRNAs within epidermal cell differentiation and proliferation, cell–cell adhesion, and skin lipids is reviewed. The critical role of miRNAs in the epidermal barrier extends the use of miRNAs for control of relevant skin diseases such as atopic dermatitis, ichthyoses, and psoriasis via miRNA-based technologies. Most of the relevant miRNAs have been associated with keratinocyte differentiation and proliferation. Few studies have investigated the association of miRNAs with structural proteins of corneocytes and cornified envelopes, cell–cell adhesion, and skin lipids. Further studies investigating the association between regulatory and structural components of epidermal barrier and miRNAs are needed to elucidate the role of miRNAs in epidermal barrier integrity and their clinical implications.

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Up-regulated lncRNA-MSX2P1 promotes the growth of IL-22-stimulated keratinocytes by inhibiting miR-6731-5p and activating S100A7

Cited by 55 publications

References 40 publications

The eminent roles of ncRNAs in the pathogenesis of psoriasis

The eminent roles of ncRNAs in the pathogenesis of psoriasis

Pathogenesis of psoriasis in the “omic” era. Part II. Genetic, genomic and epigenetic changes in psoriasis

The Role of MicroRNAs in Epidermal Barrier

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