Up-regulation by clarithromycin of α1-acid glycoprotein expression in liver and primary cultured hepatocytes

Komori, Takafumi; Kai, Hirofumi; Shimoishi, Kazuki; Kabu, Koki; Nonaka, Ayumi; Maruyama, Toru; Tamura, Keiji; Otagiri, Masaki

doi:10.1016/s0006-2952(01)00778-x

Cited by 14 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hepatocytes and the liver are the primary sources of ORM synthesis. [17][18][19][20] ORM1 has various biological functions, including being a biomarker for disease, immunomodulatory effects, and roles in important drug-binding processes, transporting proteins in the serum with albumin and lipoproteins, maintaining capillary barrier function, and various metabolisms. ORM1 serum and saliva concentration can change due to stressful stimuli, such as physical trauma, bacterial infection, and unspecific inflammatory stimuli.…”

Section: Overview Of Orosomucoidmentioning

confidence: 99%

The role of salivary orosomucoid 1 as an early diagnostic and prognostic biomarker of hepatocellular carcinoma related to Hepatitis B: A systematic review

Limijadi

Rahmawati

et al. 2023

F1000Res

View full text Add to dashboard Cite

Background: Salivary orosomucoid 1 (ORM1) is highly increased in hepatocellular carcinoma related to hepatitis B. Thus, this study aims to investigate the role of salivary ORM1 as an early diagnostic and prognostic biomarker of HCC related to hepatitis B. Methods: The sources included were original articles published from 2013 until 2023 (last date searched, January 2023) from ProQuest, Google Scholar, Springer, and ScienceDirect. The inclusion criteria were original research articles (observational cohort or diagnostic studies). Other article reviews, meta-analyses, non-comparative research, and in silico, in vitro and in vivo studies, technical reports, editor responses, conference abstracts, non-English, non-full-text, and irrelevant articles that were not related to either salivary ORM1, or hepatocellular carcinoma, hepatitis B, or kidney failure were excluded. Then, the ROBINS-I took was used to assess bias . The result was constructed with PICOS criteria within the table created in the google spreadsheet. This systematic review followed the PRISMA guidelines. Results: We included five diagnostic studies with 533 samples conducted in China and Japan. Even though limited original studies with homogenous PICO was a limitation, the evidence output of this study can still be well presented. Salivary ORM1 may be useful to detect early cancer diagnosis as rapidly increased levels of ORM1 can be observed in the early stages of HCC (four times higher than usual) and the biomarker has a sensitivity of 81.67% and a specificity of 77.5%. This biomarker is also able to detect the prognosis of individuals with the disease with or without chemotherapy because the higher the level of ORM1, the more liver damage occurs that leads to a poorer prognosis. Conclusions: Salivary ORM1 is a potential early diagnostic biomarker of HCC related to hepatitis B and a biomarker of the disease prognosis. Registration: Open Science Framework (OSF) (March 16, 2023).

show abstract

Section: Overview Of Orosomucoidmentioning

confidence: 99%

The role of salivary orosomucoid 1 as an early diagnostic and prognostic biomarker of hepatocellular carcinoma related to Hepatitis B: A systematic review

Limijadi

Rahmawati

et al. 2023

F1000Res

View full text Add to dashboard Cite

show abstract

“…From this standpoint, Wan J. et al focused-on macrolide antibiotics, which are reported to up-regulate ORM levels [237]. They evaluated several macrolides' effect and mechanisms in muscle endurance, in order to provide potential treatments for muscle fatigue.…”

Section: Muscle Fatiguementioning

confidence: 99%

Mitochondria and Antibiotics: For Good or for Evil?

et al. 2021

View full text Add to dashboard Cite

The discovery and application of antibiotics in the common clinical practice has undeniably been one of the major medical advances in our times. Their use meant a drastic drop in infectious diseases-related mortality and contributed to prolonging human life expectancy worldwide. Nevertheless, antibiotics are considered by many a double-edged sword. Their extensive use in the past few years has given rise to a global problem: antibiotic resistance. This factor and the increasing evidence that a wide range of antibiotics can damage mammalian mitochondria, have driven a significant sector of the medical and scientific communities to advise against the use of antibiotics for purposes other to treating severe infections. Notwithstanding, a notorious number of recent studies support the use of these drugs to treat very diverse conditions, ranging from cancer to neurodegenerative or mitochondrial diseases. In this context, there is great controversy on whether the risks associated to antibiotics outweigh their promising beneficial features. The aim of this review is to provide insight in the topic, purpose for which the most relevant findings regarding antibiotic therapies have been discussed.

show abstract

Genetic variations of orosomucoid genes associated with serum alpha‐1‐acid glycoprotein level and the pharmacokinetics of paclitaxel in Japanese cancer

Katori

Sai

Saito

et al. 2011

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Up-regulation by clarithromycin of α1-acid glycoprotein expression in liver and primary cultured hepatocytes

Cited by 14 publications

References 18 publications

The role of salivary orosomucoid 1 as an early diagnostic and prognostic biomarker of hepatocellular carcinoma related to Hepatitis B: A systematic review

The role of salivary orosomucoid 1 as an early diagnostic and prognostic biomarker of hepatocellular carcinoma related to Hepatitis B: A systematic review

Mitochondria and Antibiotics: For Good or for Evil?

Genetic variations of orosomucoid genes associated with serum alpha‐1‐acid glycoprotein level and the pharmacokinetics of paclitaxel in Japanese cancer

Contact Info

Product

Resources

About