Up-regulation of Gelatinases and Tissue Type Plasminogen Activator by Root Canal Sealers in Human Osteoblastic Cells

Huang, Fu‐Mei; Yang, Shun‐Fa; Chang, Yu‐Chao

doi:10.1016/j.joen.2007.12.021

Cited by 25 publications

(34 citation statements)

References 33 publications

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“…Thus a reduction in TIMP after cleaning and shaping and their lower half life can cause lysis of the dentin collagen matrix by the remaining MMP in the radicular dentin. This is similar to studies where the MMPs that are present in the remaining dentine were activated by various root canal sealers (Huang 2008) and adhesive systems that are used to cement post endodontic restorations (Tay 2006) and caused a reduction in the bond strength over time. Chlorhexidine, a root canal irrigant is one of the synthetic substances known to possess strong MMP inhibitory activity even at low concentrations (Tjaderhane 1998).…”

Section: Discussionsupporting

confidence: 79%

Identification TIMP-1 and TIMP-2 in Human Radicular Dentine - In Vitro Study

Kandaswamy

Ismail

Rosaline

et al. 2014

JADE

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Aim: To identify TIMP -1 and TIMP -2 in human radicular dentine using confocal laser scanning microscopy. Materials and Methods: Thirty freshly extracted non carious human single rooted pre molars were obtained and stored in isotonic saline at -70°C prior to use. All the teeth were decoronated at the CEJ using a diamond. Teeth were divided into 2 groups (Group 1: TIMP-1 analysis n = 15; Group 2: TIMP-2 analysis n = 15). Teeth were sectioned using a hard tissue microtome, mounted and viewed under confocal laser scanning microscopy. Results: TIMP-1 and TIMP-2 were detected in radicular dentine and were seen to be distributed more towards the inner dentine layer closer to the pulp. Conclusion: Due to a shorter half life of TIMP-1 and 2 as compared to the MMP, there is a need to use MMP inhibitors prior to obturation of the root canal.

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Section: Discussionsupporting

confidence: 79%

Identification TIMP-1 and TIMP-2 in Human Radicular Dentine - In Vitro Study

Kandaswamy

Ismail

Rosaline

et al. 2014

JADE

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“…This fact raises concern about the longevity of adhesive procedures that are increasingly being applied to root substrate as bonded root fillings and post cementation with resin cements. In addition, recent studies have shown that byproducts of both root canal sealers (30) and bacteria related to endodontic infections (31) were able to activate at least proMMP-2 and -9, two of the dentinal MMPs that are thought to be involved with the degradation of collagen fibrils within resin-bonded dentin interfaces (9,21).…”

Section: Discussionmentioning

confidence: 99%

Determination of Matrix Metalloproteinases in Human Radicular Dentin

Santos

Carrilho

Tervahartiala

et al. 2009

Journal of Endodontics

114

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“…Unfortunately, several studies have shown that most commercially available root canal sealers can induce mild to severe inflammatory alteration within apical tissues (1)(2)(3)(4). Recently, our studies have shown the activation of cyclooxygenase (COX)-2 (5-7), interleukin (IL)-6 (8), , heme oxygenase-1 (9), gelatinases (10), and tissue type plasminogen activators (10) might play an important role in induction of periapical destruction by root canal sealers. However, little is known about how root canal sealers influence the osteolytic mediator expression in induction of periapical bone destruction by root canal sealers.…”

mentioning

confidence: 99%