Up-regulation of interleukin-6 and vascular endothelial growth factor-A in the synovial fluid of temporomandibular joints affected by synovial chondromatosis

Wake, Masahiro; Hamada, Y.; Kumagai, Koshi; Tanaka, Nobuhiro; Ikeda, Yasuko; Nakatani, Yasunori; Suzuki, Ryuji; Fukui, Naoshi

doi:10.1016/j.bjoms.2012.03.004

Cited by 28 publications

(25 citation statements)

References 25 publications

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“…However, in another previous study, levels of IL-6 were determined to be comparable in the synovial fluids from patients with TMJ and OA, and healthy patients with TMJ (32). Previous studies (32,36–38) have revealed a negative correlation between frequently isolated cytokines, IL-6 (32), TNF-α (37,38) and IL-1β (36,38) and TMD. Kaneyama et al (38) suggested that no correlation was observed between the IL-1β or TNF-α levels and condyle degenerative changes due to the rapid turnover of cytokines within the joint cavity (38).…”

Section: Discussionmentioning

confidence: 87%

“…Previous studies have demonstrated that cytokines including IL-1β (9,11,12,31,32), IL-6 (9,11,12,31,33–37) and TNF-α (8,11,31,32,34,35) are associated with inflammation in synovial joints and loss of the connective tissue in TMJ. Therefore, it is possible that increased levels of these cytokines may be observed in the synovial fluid of patients with TMD.…”

Section: Discussionmentioning

confidence: 99%

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Elastin-derived peptides are involved in the processes of human temporomandibular disorder by inducing inflammatory responses in synovial cells

Kobayashi

Jokaji

Miyazawa-Hira

et al. 2017

Molecular Medicine Reports

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Temporomandibular joint dysfunction (TMD) is a collection of clinical symptoms that involve masticatory muscles and the temporomandibular joint (TMJ). Common symptoms include limited jaw motion and joint sound/pain, along with TMJ disc displacement. TMD is frequently associated with synovitis, a chronic inflammation of the synovium. Fibroblast-like synovial cells have been identified to produce several inflammatory mediators and may have an important role in the progression of TMJ inflammation. Degradation of the extracellular matrix molecule elastin may lead to the release of bioactive peptides. The present study aimed to explore the role of elastin-derived peptides (EDPs) in human temporomandibular disorders. Therefore, interleukin-6 (IL-6) expression in the synovial fluid obtained from patients with TMD correlated significantly with two clinical parameters, specifically TMJ locking and pain/jaw function on a visual analog scale (VAS). To the best of our knowledge, this is the first study to determine that the concentration of EDPs in synovial fluid from patients with TMD may also be significantly correlated with the duration of TMJ locking, the VAS score and IL-6 expression. In vitro, EDPs act on human TMJ synovial cells to promote upregulation of IL-6 and the elastin-degrading enzyme matrix metalloproteinase-12 (MMP-12). The upregulation of IL-6 and MMP-12 expression by EDPs may be mediated through elastin-binding proteins (EBP) and a protein kinase A signalling cascade. These findings suggest a model for inflammation in the TMJ where EDPs are generated by harmful mechanical stimuli, induce both a pro-inflammatory cascade and increase expression of MMP-12 through activation of the EBP signalling cascade. This may lead to further increases in EDP levels, establishing a positive feedback loop leading to chronic inflammation in the TMJ. Therefore, significantly elevated levels of EDPs and IL-6 in the synovial fluid of the TMJ may be indicators of the pathological conditions of the joint.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Elastin-derived peptides are involved in the processes of human temporomandibular disorder by inducing inflammatory responses in synovial cells

Kobayashi

Jokaji

Miyazawa-Hira

et al. 2017

Molecular Medicine Reports

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“…In healthy conditions, the SF concentration of most small molecules is similar to the concentration in plasma [18]. TMJ SF sampling enables investigation of joint pathology, disease progression and aetiology and has been used in different TMJ pathologies [1,[19][20][21]. The number of studies on TMJ SF is rather large; however, to our knowledge, no studies have focused on the subjective experience of the patients undergoing SF sampling.…”

Section: Discussionmentioning

confidence: 96%

Signs and symptoms after temporomandibular joint washing and cannula placement assessed by cone beam computerized tomography

Kristensen

Stoustrup

Alstergren

et al. 2014

Acta Odontologica Scandinavica

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“…4 Recently, many hypotheses have been suggested for the formation of the loose bodies. Wake et al, 5 in 2012, suggested that the osteocartilaginous nodules massively express IL-6 and VEGF-A, playing an important role in the pathology of SC. Yoshida et al, 6 in 2013, reported low levels of Ki-67 around loose bodies and mild levels in cases of loose bodies attached to the synovial membrane, suggesting a related proliferant activity.…”

Section: Discussionmentioning

confidence: 98%

Temporomandibular Synovial Chondromatosis With Numerous Nodules

Cascone¹,

Gennaro²,

Gabriele³

et al. 2014

Journal of Craniofacial Surgery

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Up-regulation of interleukin-6 and vascular endothelial growth factor-A in the synovial fluid of temporomandibular joints affected by synovial chondromatosis

Cited by 28 publications

References 25 publications

Elastin-derived peptides are involved in the processes of human temporomandibular disorder by inducing inflammatory responses in synovial cells

Elastin-derived peptides are involved in the processes of human temporomandibular disorder by inducing inflammatory responses in synovial cells

Signs and symptoms after temporomandibular joint washing and cannula placement assessed by cone beam computerized tomography

Temporomandibular Synovial Chondromatosis With Numerous Nodules

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