Up-regulation of leukaemia inhibitory factor and interleukin-6 in transected sciatic nerve and muscle following denervation

Kurek, John B.; Austin, L.; Cheema, Surindar S.; Bartlett, Perry F.; Murphy, Mark

doi:10.1016/0960-8966(95)00029-1

Cited by 152 publications

(101 citation statements)

References 33 publications

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“…The mRNA for LIF is upregulated in the neurons and glia of human patients with subacute sclerosing panencephalitis, a long-term inflammatory measles virus infection [105]. A dramatic rise in LIF mRNA is also observed following sciatic or olfactory nerve transection, cortical stab wound, excitatory amino acid-induced injury to the spinal cord, and seizure [106][107][108][109][110][111][112]. In LIF KO mice, infiltration by neutrophils, macrophages, and mast cells is delayed compared with wildtype in both CNS and PNS lesions [113,114].…”

Section: Lif In Neural Inflammationmentioning

confidence: 99%

Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury

1999

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Inflammation refers to a complex set of mechanisms by which tissues respond to injury and infection. Among the many soluble mediators associated with this process, cytokines are known to be crucial in regulating a variety of cellular and molecular events. Leukemia inhibitory factor (LIF), interleukin 6 (IL-6), IL-11, and possibly other members of this cytokine family are key mediators in various inflammatory processes such as the acute-phase reaction, tissue damage, and infection. These cytokines can act in both pro-inflammatory and anti-inflammatory ways, depending on a number of variables. We emphasize here recent work utilizing knockout mice, which has highlighted the roles of LIF and IL-6, particularly in interactions between the immune and nervous systems.

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Section: Lif In Neural Inflammationmentioning

confidence: 99%

Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury

1999

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“…This inflammatory role has been documented in CNS tissues and in skin. 11,[19][20][21][22][23][24] New vessel formation in the cornea is a significant factor contributing to visual morbidity. Although factors such as VEGF, which modulates cornea, and new vascularisation has been characterised, the process of vascularisation is far from clear.…”

Section: Discussionmentioning

confidence: 99%

Immunolocalisation of leukaemia inhibitory factor in the cornea

Ramaesh

West

et al. 2004

Eye

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Aim Leukaemia inhibitory factor (LIF) is a pleotrophic cytokine expressed in a variety of cell types, and have shown to regulate stem cell proliferation, vascular genesis, inflammation, and immunity in various locations. Expression of LIF and its role in the cornea have not been studied previously. In this study, we examined the expression of LIF in the cornea. Materials and methodImmunohistochemistry was performed using polyclonal LIF antibodies, and Avidin-Biotin ABC complex on cultured human corneal epithelium corneal fibroblasts and wild-type murine corneal epithelium. Results LIF was detected in the cytoplasm of murine corneal epithelium, cultured human corneal epithelium, and fibroblasts. The expression of LIF was mainly cytoplasmic. Conclusion LIF is expressed in the corneal epithelium and fibroblasts. It may have an important role in the maintenance of homeostasis of the corneal epithelium and cornea stroma. Further studies are necessary to elucidate the role of LIF in the cornea.

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“…Direct application of LIF to sites of nerve transaction improved survival of both sensory and motor neurons (18,19). Nerve transection has been shown to increase expression of LIF and IL-6, and is associated with retrograde axonal transport of LIF (20). LIF has also been shown to retard progression of motor neuron disease in a murine model of this disorder (21).…”

Section: Introductionmentioning

confidence: 99%

Codon Optimization, Cloning and Expression of the Human Leukemia Inhibitory Factor (hLIF) in E. coli

et al. 2012

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Up-regulation of leukaemia inhibitory factor and interleukin-6 in transected sciatic nerve and muscle following denervation

Cited by 152 publications

References 33 publications

Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury

Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury

Immunolocalisation of leukaemia inhibitory factor in the cornea

Codon Optimization, Cloning and Expression of the Human Leukemia Inhibitory Factor (hLIF) in E. coli

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