Up-regulation of miR-663a inhibits the cancer stem cell-like properties of glioma via repressing the KDM2A-mediated TGF-β/SMAD signaling pathway

Wang, Lei; Lang, Bojuan; Zhou, Youdong; Ma, Jinyang; Hu, Keqi

doi:10.1080/15384101.2021.1966962

Cited by 13 publications

(10 citation statements)

References 47 publications

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“…The processes to be considered that deal with the specificity of the miRs that modulate the CSC gene expression [ 83 ] and the cascades involved in their signaling, are numerous [ 41 , 53 , 64 , 84 ]. The opposite effects of inhibition or reinforcement are induced by drugs, rather than CSC action [ 36 , 84 ].…”

Section: Development Of Therapies: Methods and Toolsmentioning

confidence: 99%

“…On the other hand, human liver cancer is attenuated in vitro and in vivo by miR-145 and miR-200 [ 48 ]; inhibition of lung metastasis is induced in osteosarcoma by miR-101 [ 49 ]; miR-8063 inhibits self renewal of GSC [ 50 ]; miR-663 inhibits the CSCs of a glioma [ 51 ]; and miR-1468-5p promotes a tumor immune escape [ 52 ]. Interestingly, many of the effects reported in this section, induced by CSCs and miRs, are mediated by the activation of various signaling pathways such AKT [ 22 , 46 ], GSK3-β [ 22 ], Wnt/β-catenin [ 22 , 23 , 50 , 51 ], and TGF-β/SMAD [ 53 ].…”

Section: Cscs and Their Evs Are Essential For Cancer Initiation And Its Processesmentioning

confidence: 99%

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Cancer Stem Cells and Their Vesicles, Together with Other Stem and Non-Stem Cells, Govern Critical Cancer Processes: Perspectives for Medical Development

Meldolesi

2022

IJMS

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Stem cells, identified several decades ago, started to attract interest at the end of the nineties when families of mesenchymal stem cells (MSCs), concentrated in the stroma of most organs, were found to participate in the therapy of many diseases. In cancer, however, stem cells of high importance are specific to another family, the cancer stem cells (CSCs). This comprehensive review is focused on the role and the mechanisms of CSCs and of their specific extracellular vesicles (EVs), which are composed of both exosomes and ectosomes. Compared to non-stem (normal) cancer cells, CSCs exist in small populations that are preferentially distributed to the niches, such as minor specific tissue sites corresponding to the stroma of non-cancer tissues. At niches and marginal sites of other cancer masses, the tissue exhibits peculiar properties that are typical of the tumor microenvironment (TME) of cancers. The extracellular matrix (ECM) includes components different from non-cancer tissues. CSCs and their EVs, in addition to effects analogous to those of MSCs/EVs, participate in processes of key importance, specific to cancer: generation of distinct cell subtypes, proliferation, differentiation, progression, formation of metastases, immune and therapy resistance, cancer relapse. Many of these, and other, effects require CSC cooperation with surrounding cells, especially MSCs. Filtered non-cancer cells, especially macrophages and fibroblasts, contribute to collaborative cancer transition/integration processes. Therapy developments are mentioned as ongoing preclinical initiatives. The preliminary state of clinical medicine is presented in terms of both industrial development and future treatments. The latter will be administered to specific patients together with known drugs, with the aim of eradicating their tumor growth and metastases.

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Section: Development Of Therapies: Methods and Toolsmentioning

confidence: 99%

Section: Cscs and Their Evs Are Essential For Cancer Initiation And Its Processesmentioning

confidence: 99%

Cancer Stem Cells and Their Vesicles, Together with Other Stem and Non-Stem Cells, Govern Critical Cancer Processes: Perspectives for Medical Development

Meldolesi

2022

IJMS

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“…115), in glioma via KDM2A-mediated signalling (Ref. 116) and in liver cancers through the PJA1 molecular axis (Ref. 117).…”

Section: Tgf-β and Cancer Hallmarksmentioning

confidence: 99%

Roles of TGF-β in cancer hallmarks and emerging onco-therapeutic design

Dai

Dong

2022

Expert Rev. Mol. Med.

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Transforming growth factor-beta (TGF-β) is a double-edged sword in cancer treatment because of its pivotal yet complex and roles played during cancer initiation/development. Current anti-cancer strategies involving TGF-β largely view TGF-β as an onco-therapeutic target that not only substantially hinders its full utilisation for cancer control, but also considerably restricts innovations in this field. Thereby, how to take advantages of therapeutically favourable properties of TGF-β for cancer management represents an interesting and less investigated problem. Here, by categorising cancer hallmarks into four critical transition events and one enabling characteristic controlling cancer initiation and progression, and delineating TGF-β complexities according to these cancer traits, we identify the suppressive role of TGF-β in tumour initiation and early-stage progression and its promotive functionalities in cancer metastasis as well as other cancer hallmarks. We also propose the feasibility and possible scenarios of combining cold atmospheric plasma (CAP) with onco-therapeutics utilising TGF-β for cancer control given the intrinsic properties of CAP against cancer hallmarks.

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“…miR-132 enhances the activation of TGF-β signaling by inhibiting Smad7 expression in glioma cells (Wang et al, 2015 ). TGF-β also acts as a downstream target of lysine demethylase 2A (KDM2A), which regulates cell proliferation, while upregulation of miR-663a inhibits migration and invasion by suppressing KDM2A (Wang L. et al, 2021 ).…”

Section: Mirnas and Their Molecular Mechanisms In The Key Glioma Sign...mentioning

confidence: 99%

Biological implications and clinical potential of invasion and migration related miRNAs in glioma

Guo

Jiao

Cao

et al. 2022

Front. Integr. Neurosci.

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Gliomas are the most common primary malignant brain tumors and are highly aggressive. Invasion and migration are the main causes of poor prognosis and treatment resistance in gliomas. As migration and invasion occur, patient survival and prognosis decline dramatically. MicroRNAs (miRNAs) are small, non-coding 21–23 nucleotides involved in regulating the malignant phenotype of gliomas, including migration and invasion. Numerous studies have demonstrated the mechanism and function of some miRNAs in glioma migration and invasion. However, the biological and clinical significance (including diagnosis, prognosis, and targeted therapy) of glioma migration and invasion-related miRNAs have not been systematically discussed. This paper reviews the progress of miRNAs-mediated migration and invasion studies in glioma and discusses the clinical value of migration and invasion-related miRNAs as potential biomarkers or targeted therapies for glioma. In addition, these findings are expected to translate into future directions and challenges for clinical applications. Although many biomarkers and their biological roles in glioma invasion and migration have been identified, none have been specific so far, and further exploration of clinical treatment is still in progress; therefore, we aimed to further identify specific markers that may guide clinical treatment and improve the quality of patient survival.

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Up-regulation of miR-663a inhibits the cancer stem cell-like properties of glioma via repressing the KDM2A-mediated TGF-β/SMAD signaling pathway

Cited by 13 publications

References 47 publications

Cancer Stem Cells and Their Vesicles, Together with Other Stem and Non-Stem Cells, Govern Critical Cancer Processes: Perspectives for Medical Development

Cancer Stem Cells and Their Vesicles, Together with Other Stem and Non-Stem Cells, Govern Critical Cancer Processes: Perspectives for Medical Development

Roles of TGF-β in cancer hallmarks and emerging onco-therapeutic design

Biological implications and clinical potential of invasion and migration related miRNAs in glioma

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