Up-regulation of neutral endopeptidase (CALLA) in human neutrophils by granulocyte-macrophage colony-stimulating factor

Connelly, Jon C.; Chambless, Robin; Holiday, David; Chittenden, Kim; Johnson, Alice

doi:10.1002/jlb.53.6.685

Cited by 24 publications

(8 citation statements)

References 33 publications

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“…CD10 expression on the neutrophil surface seems to be up-regulated by many factors, such as lipopolysaccharide and granulocyte/macrophage-colony-stimulating factor (Connelly et al 1993;Fagny et al 1995). A close association of CD10 expression with some diseases has been described.…”

Section: Discussionmentioning

confidence: 96%

The ratio of neutrophils to lymphocytes and the phenotypes of neutrophils in patients with early gastric cancer

Hirashima¹,

Higuchi

Saito

et al. 1998

Journal of Cancer Research and Clinical Oncology

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We examined 55 patients (40 male, 15 female) who were diagnosed from 1987 to 1991 as having early gastric cancer (EGC) stage I according to the general rules of classification of the Japanese Research Society for Gastric Cancer. Of the 55 patients, 42 (30 male, 12 female) were alive in April 1992. The prognosis correlated well with the ratio of neutrophils to lymphocytes (N/L ratio) but not with the total number of white blood cells in the peripheral blood. The patients were divided into two groups according to their N/L ratio. Of the 29 patients with an N/L ratio less than 2, 27 were alive in 1992, whereas only 15 of the 26 patients with an N/L ratio of 2 or more were alive (chi2 analysis, P=0.0022). We further examined the phenotypes of neutrophils from 29 other patients with EGC at the time of diagnosis before surgical operation. These patients were divided into two groups: 17 patients with a low N/L ratio (less than 2) and 12 patients with a high N/L ratio (2 or more). CD10 and CD35 expressions on neutrophils from the patients with a low N/L ratio were lower than those from the patients with a high N/L ratio. The N/L ratio correlated well with both CD10 and CD35 expression, whereas no correlation was observed between the numbers of neutrophils and the expression of these phenotypes. The respiratory burst of neutrophils from the patients with a high N/L ratio was higher than that of neutrophils from the patients with a low N/L ratio, though there was no correlation in the phagocytic activity between both groups. It was thus suggested that the heterogeneity of neutrophils is, at least partly, related to the prognosis of patients with EGC.

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Section: Discussionmentioning

confidence: 96%

The ratio of neutrophils to lymphocytes and the phenotypes of neutrophils in patients with early gastric cancer

Hirashima¹,

Higuchi

Saito

et al. 1998

Journal of Cancer Research and Clinical Oncology

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“…This indicates that tumor-infiltrating neutrophils were divided into a high CD10-expressing group and a low CD10-expressing group. Granulocyte-macrophage colony-stimulating factor (GM-CSF) can enhance CD10 expression in normal neutrophils in vitro 22. Its serum level was significantly higher in CRC than in normal persons 23.…”

Section: Discussionmentioning

confidence: 99%

The Expression of CD10 and CD15 Is Progressively Increased during Colorectal Cancer Development

2013

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BackgroundThe aim of this study was to examine the expression of CD10 and CD15 in tumor cells, stromal cells and infiltrating inflammatory cells during colorectal carcinoma (CRC) development and to investigate their expression levels between the tumor center and invasive front and compare them to clinicopathological parameters in invasive CRC.MethodsWe performed immunohistochemical staining for CD10, CD15, and E-cadherin in 42 cases of CRC, 49 of tubular adenoma, 15 of hyperplastic polyp, and 17 of non-neoplastic colon.ResultsCD10 was expressed in tumor cells (tCD10), stromal cells (sCD10) and infiltrating inflammatory cells (iCD10), and CD15 was expressed in tumor cells (tCD15) and infiltrating inflammatory cells (iCD15). Their expressions were progressively increased during CRC development and the iCD10 expression level was significantly correlated with the iCD15 expression level in invasive CRC. Invasive front revealed a higher expression level of iCD10 and iCD15 than the tumor center. Moreover, the iCD15 expression level of invasive front was significantly correlated with the degree of tumor budding and tCD15 in whole tissue sections was closely associated with tumor depth.ConclusionsThe present study suggests that the expression of CD10 and CD15 is associated with the development and progression of CRC.

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“…NEP has previously been shown to be expressed by leukocytes and process peptides involved in migration such bacterial chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (fMLP). Inhibition of CD10/NEP on the surface of human neutrophils (PMNs) in vitro inhibits migration toward this chemotaxin, suggesting that enzymatic inactivation by NEP regulates the neutrophil response to fMLP[47].…”

Section: Discussionmentioning

confidence: 99%

Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

et al. 2011

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Alzheimer's disease (AD), an incurable, progressive neurodegenerative disorder, is the most common form of dementia. Therapeutic options have been elusive due to the inability to deliver proteins across the blood-brain barrier (BBB). In order to improve the therapeutic potential for AD, we utilized a promising new approach for delivery of proteins across the BBB. We generated a lentivirus vector expressing the amyloid β-degrading enzyme, neprilysin, fused to the ApoB transport domain and delivered this by intra-peritoneal injection to amyloid protein precursor (APP) transgenic model of AD. Treated mice had reduced levels of Aβ, reduced plaques and increased synaptic density in the CNS. Furthermore, mice treated with the neprilysin targeting the CNS had a reversal of memory deficits. Thus, the addition of the ApoB transport domain to the secreted neprilysin generated a non-invasive therapeutic approach that may be a potential treatment in patients with AD.

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Up-regulation of neutral endopeptidase (CALLA) in human neutrophils by granulocyte-macrophage colony-stimulating factor

Cited by 24 publications

References 33 publications

The ratio of neutrophils to lymphocytes and the phenotypes of neutrophils in patients with early gastric cancer

The ratio of neutrophils to lymphocytes and the phenotypes of neutrophils in patients with early gastric cancer

The Expression of CD10 and CD15 Is Progressively Increased during Colorectal Cancer Development

Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

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