Up-regulation of T lymphocyte and antibody production by inflammatory cytokines released by macrophage exposure to multi-walled carbon nanotubes

Grecco, Ana Carolina Pimenta; Paula, Rosemeire F.O. de; Mizutani, Erica; Sartorelli, Juliana C; Milani, Ana M; Longhini, Ana Leda; Oliveira, E. Capelas de; Pradella, Fernando; Silva, Vania D. R.; Moraes, Adriel S.; Peterlevitz, Alfredo C.; Farias, Alessandro S.; Ceragioli, Helder José; Santos, Leonilda Maria Barbosa dos; Baranauskas, Vı́tor

doi:10.1088/0957-4484/22/26/265103

Cited by 30 publications

(26 citation statements)

References 23 publications

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“…In the previous studies, p-MWCNTs have been shown to activate the monocytes or macrophages and induce pro-inflammatory cytokine secretion inflammation, which resulted in an increase in the immune response of nanotubes. 15,16 Similarly, the same sequence of research reported increases of pro-inflammatory cytokines and the allergy-like response detected by mice after intratracheal instillation of non-functionalized MWCNTs. 17 Meanwhile, it was also reported that MWCNTs could lead to systemic immune suppression in mice after whole-body inhalation, 18 and then the researchers demonstrated that MWCNTs could induce suppression of systemic immunity through activation of the cyclooxygenase pathway.…”

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confidence: 70%

Systemic and immunotoxicity of pristine and PEGylated multi-walled carbon nanotubes in an intravenous 28 days repeated dose toxicity study

Zhang¹,

Meng²,

Zhang³

et al. 2017

IJN

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The numerous increasing use of carbon nanotubes (CNTs) derived from nanotechnology has raised concerns about their biosafety and potential toxicity. CNTs cause immunologic dysfunction and limit the application of CNTs in biomedicine. The immunological responses induced by pristine multi-walled carbon nanotubes (p-MWCNTs) and PEGylated multi-walled carbon nanotubes (MWCNTs-PEG) on BALB/c mice via an intravenous administration were investigated. The results reflect that the p-MWCNTs induced significant increases in spleen, thymus, and lung weight. Mice treated with p-MWCNTs showed altered lymphocyte populations (CD3 + , CD4 + , CD8 + , and CD19 + ) in peripheral blood and increased serum IgM and IgG levels, and splenic macrophage ultrastructure indicated mitochondria swelling. p-MWCNTs inhibited humoral and cellular immunity function and were associated with decreased immune responses against sheep erythrocytes and serum hemolysis level. Natural killer (NK) activity was not modified by two types of MWCNTs. In comparison with two types of MWCNTs, for a same dose, p-MWCNTs caused higher levels of inflammation and immunosuppression than MWCNTs-PEG. The results of immunological function suggested that after intravenous administration with p-MWCNTs caused more damage to systemic immunity than MWCNTs-PEG. Here, we demonstrated that a surface functional modification on MWCNTs reduces their immune perturbations in vivo. The chemistry-modified MWCNTs change their preferred immune response in vivo and reduce the immunotoxicity of p-MWCNTs.

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confidence: 70%

Systemic and immunotoxicity of pristine and PEGylated multi-walled carbon nanotubes in an intravenous 28 days repeated dose toxicity study

Zhang¹,

Meng²,

Zhang³

et al. 2017

IJN

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“…NPC were prepared by HFCVD (Hot Filament Chemical Vapor Deposition) using acetone as carbon atoms source on a polished copper foil substrate as described previously (Grecco et al, 2011). The processing for NPG was the same described before to maintain identical properties (Mendonca et al, 2015).…”

Section: Construction Of the Prosthesis For Tubulizationmentioning

confidence: 99%

Sciatic nerve repair using poly(ε‐caprolactone) tubular prosthesis associated with nanoparticles of carbon and graphene

et al. 2017

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“…As far as it can be presently stated, adaptive immunity thus seems to play a minor role in CNT-mediated immune effects, which contrasts the above-described situation in innate immunity, where CNTs have been shown to mediate considerate immunogenicity. However, the close interconnection between innate and adaptive immunity promises potential applications of CNTs as (Th1-promoting) immunostimulatory carriers (adjuvants) for vaccines [79,89,139], while on the other hand it poses the risk of side-effects, such as hypersensitivity [93].…”

Section: Cnt-induced Immune Responses Within the Venous System-immunomentioning

confidence: 99%

The Significance and Insignificance of Carbon Nanotube-Induced Inflammation

Boyles

Stoehr

Schlinkert

et al. 2014

Fibers

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In the present review article immune responses induced by carbon nanotubes (CNTs) are addressed. As inhalation is considered to be the primary entry route, and concern has been raised by similar high aspect ratio materials, the main focus lies on immune responses upon pulmonary exposure. Inflammation-related findings from both in vivo studies and in vitro models are reviewed, and the major responsible characteristics, which may drive CNT-induced inflammation in the lung, are discussed. In a second part, responses upon intentional administration of CNTs via subcutaneous and intravenous application are addressed, including their potential benefits and drawbacks for immunotherapy. Finally, the gastrointestinal tract as an alternative exposure route is briefly discussed. While there are many studies identifying numerous other factors involved in CNT-driven toxicity, e.g., cytotoxicity, oxidative stress, and genotoxicity, the focus of this review was kept solely on CNT-induced inflammation. Overall the literature has shown that CNTs are able to induce inflammation, which in some cases was a particularly robust response coinciding with the development of pro-fibrotic conditions. In the majority of cases the greatest inflammatory responses were associated with CNTs of considerable length and a high aspect ratio, accompanied by other factors like dispersion and sample purity.

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Up-regulation of T lymphocyte and antibody production by inflammatory cytokines released by macrophage exposure to multi-walled carbon nanotubes

Cited by 30 publications

References 23 publications

Systemic and immunotoxicity of pristine and PEGylated multi-walled carbon nanotubes in an intravenous 28 days repeated dose toxicity study

Systemic and immunotoxicity of pristine and PEGylated multi-walled carbon nanotubes in an intravenous 28 days repeated dose toxicity study

Sciatic nerve repair using poly(ε‐caprolactone) tubular prosthesis associated with nanoparticles of carbon and graphene

The Significance and Insignificance of Carbon Nanotube-Induced Inflammation

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