Up-to-date evidence on image-guided thermal ablation for metastatic lung tumors: a review

Matsui, Yusuke; Tomita, Koji; Uka, Mayu; Umakoshi, Noriyuki; Kawabata, Takahiro; Munetomo, Kazuaki; Nagata, Shoma; Iguchi, Toshihiro; Hiraki, Takao

doi:10.1007/s11604-022-01302-0

Cited by 6 publications

(3 citation statements)

References 49 publications

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“…Ablative therapies are used to treat lung metastases from various types of primary tumors. 19 The consideration of local therapy without continued systemic therapy becomes relevant to achieve long-term disease control and contribute to overall survival (OS) at well-controlled sites of metastases. Due to the relatively short follow-up period, the 1-year LC rate and RFS were the focus of the current study, and recurrence included local progression at the site of CA as well as new distant lung metastases.…”

Section: Discussionmentioning

confidence: 99%

CT-Guided Percutaneous Cryoablation for Lung Metastasis of Colorectal Cancer: A Case Series

Wang,

Luo,

Tian

et al. 2023

Technol Cancer Res Treat

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Purpose This study aimed to evaluate the efficacy of computed tomography (CT) guided percutaneous cryoablation (CA) for the management of lung metastases in patients with metastatic colorectal cancer (mCRC). Methods Retrospective analysis was performed on 38 mCRC patients with lung metastases, who underwent CT-guided percutaneous CA at our center from May 1, 2020 to November 1, 2021. The technical success rate, 1-year local control (LC) rate, recurrence-free survival (RFS) and treatment-related complications were analyzed. Results The CA procedure was successfully performed in all patients, with a technical success rate of 100%. The 1-year LC rate was 94.7% (36/38), while 16 patients experienced new distant lung metastases during the follow-up period. The median RFS was 20 months (95% CI: 13.0-27.0). The median RFS of patients with and without extrapulmonary metastasis was 15 and 23 months, respectively. Complications were reported in 18 (47.4%) patients following the CA procedure. Pneumothorax was discovered in 15 (39.5%) patients, and five of these patients (13.2%) required chest tube intubation. Two patients (5.3%) presented with hemoptysis during the CA procedure. One patient developed subcutaneous emphysema as detected in the post-procedure follow-up imaging. All patients tolerated the peri-procedural pain well under local anesthesia, and the mean visual analog scale (VAS) score was 2.8. Conclusion Lung CA is a safe and well-tolerated treatment with a satisfactory local control rate for patients with lung metastases derived from mCRC.

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Section: Discussionmentioning

confidence: 99%

CT-Guided Percutaneous Cryoablation for Lung Metastasis of Colorectal Cancer: A Case Series

Wang,

Luo,

Tian

et al. 2023

Technol Cancer Res Treat

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“…In the local treatment of HCC, RFA and MWA play a fundamental role due to their safety and efficacy in completely necrotic tumor nodes, with comparable complete response rates [32,33]. Percutaneous thermal ablation has also been established as an effective treatment for renal, lung, and bone tumors [34][35][36][37][38], as well as benign masses of the thyroid and uterus [39,40]. These therapies achieve irreversible destruction of tumor tissue by applying either hot or cold thermal energy.…”

Section: Techniques Of Thermal Ablationmentioning

confidence: 99%

Image-Guided Ablation Therapies for Extrahepatic Metastases from Hepatocellular Carcinoma: A Review

Umakoshi

Matsui

Tomita

et al. 2023

Cancers

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The most common sites of extrahepatic metastases from hepatocellular carcinoma (HCC) are the lungs, intra-abdominal lymph nodes, bones, and adrenal glands, in that order. Although systemic therapies are a common treatment for patients with extrahepatic metastases, local ablative therapies for the extrahepatic metastatic lesions can be performed in selected patients. In this article, the literature on image-guided thermal ablation for metastasis to each organ was reviewed to summarize the current evidence. Radiofrequency ablation was the most commonly evaluated technique, and microwave ablation, cryoablation, and percutaneous ethanol injection were also utilized. The local control rate of thermal ablation therapy was relatively favorable, at approximately 70–90% in various organs. The survival outcomes varied among the studies, and several studies reported that the absence of viable intrahepatic lesions was associated with improved survival rates. Since only retrospective data from relatively small studies has been available thus far, more robust studies with prospective designs and larger cohorts are desired to prove the usefulness of thermal ablation for extrahepatic metastases from HCC.

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“…Thermal ablation has gained wide acceptance in the management of HCC, but high rates of clinical success have also been demonstrated for various other liver solid tumors, such as intrahepatic cholangiocarcinoma and liver metastases from neuroendocrine tumors, colorectal cancer, and breast cancer [ 9 , 10 ], as well as in different anatomical sites, such as kidney (renal cell carcinoma and reninoma [ 11 , 12 ]) or lung (primary or metastatic lesions [ 13 , 14 ]); in the kidney, in particular, ablation showed to be effective also when compared to surgery [ 15 ], significantly expanding its impact in the field of interventional oncology.…”

Section: Introductionmentioning

confidence: 99%

Technical and Clinical Outcomes of Laparoscopic–Laparotomic Hepatocellular Carcinoma Thermal Ablation with Microwave Technology: Case Series and Review of Literature

Muglia,

Marra,

Pinelli

et al. 2023

Cancers

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Purpose: To evaluate technical and clinical outcomes of intraoperative (laparoscopic/laparotomic) microwave ablation on HCC. Materials and Methods: This is a retrospective single-center study evaluating consecutive patients treated for very early/early-stage HCC with intraoperative microwave ablation from 1 July 2017 to 30 June 2023. In these patients, a percutaneous US-guided approach was excluded due to the nodule’s suboptimal visibility or harmful location and liver resection for a deep position or adherences. Data about the clinical stage, surgical approach, liver pathology and nodules characteristics, technical success, complications, and follow-up were collected. Technical success was intended as the absence of locoregional persistence at follow-up CT/MRI controls. Results: A total of 36 cirrhotic patients (M:F = 30:6, median age 67 years) were enrolled; 18/36 (50%) had a single nodule, 13/36 (36%) had two, 4/36 had three (11%), and 1/36 had four (3%). Among the patients, 24 (67%) were treated with laparoscopy, and 12/36 (33%) with a laparotomic approach. Sixty HCCs of 16.5 mm (6–50 mm) were treated for 7 min (2–30 min) with 100 W of power. A total of 55 nodules (92%) were treated successfully and showed no residual enhancement at the first postoperative follow-up; the other 5/60 (8%) underwent chemo/radioembolization. There was one complication (3%): a biliary fistula treated with percutaneous drainage and glue embolization. The average hospital stay was 3.5 days (1–51 days), and patients were followed up on average for 238 days (13–1792 days). During follow-up, 5/36 patients (14%) underwent liver transplantation, 1/36 (2%) died during hospitalization and 1 after discharge. Conclusions: Laparoscopic/laparotomic intraoperative HCC MW ablation is feasible in patients unsuitable for percutaneous approach or hepatic resection, with rare complications and with good technical and clinical outcomes.

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Up-to-date evidence on image-guided thermal ablation for metastatic lung tumors: a review

Cited by 6 publications

References 49 publications

CT-Guided Percutaneous Cryoablation for Lung Metastasis of Colorectal Cancer: A Case Series

CT-Guided Percutaneous Cryoablation for Lung Metastasis of Colorectal Cancer: A Case Series

Image-Guided Ablation Therapies for Extrahepatic Metastases from Hepatocellular Carcinoma: A Review

Technical and Clinical Outcomes of Laparoscopic–Laparotomic Hepatocellular Carcinoma Thermal Ablation with Microwave Technology: Case Series and Review of Literature

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