Up-to-date strategies and future trends towards the extraction and purification of Capsaicin: A comprehensive review

Castro-Muñoz, Roberto; Gontarek‐Castro, Emilia; Jafari, Seid Mahdi

doi:10.1016/j.tifs.2022.03.014

Cited by 48 publications

(21 citation statements)

References 84 publications

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“…The lowest yield increment (1.42%) was obtained at 45°C with 30 min of extraction using high enzyme concentration ( Figure 2A ). Compared with conventional extraction techniques, EAE improved the extraction yield due to the direct activity through the seed cell wall, and it is potentially recognized as a green extraction technique for the use of water as a solvent ( 24 ). Magaña-Barajas et al reported that for ethanolic conventional extraction of CAP from Capsicum chinense , the extraction yield reached 40%, our results show that using high enzyme concentration at 60°C with 150 min of the process shows an extraction yield of 73% demonstrating that the use of this novel technique could improve the recovery of bioactive compounds ( 25 ).…”

Section: Resultsmentioning

confidence: 99%

Enzyme-assisted extraction of anti-inflammatory compounds from habanero chili pepper (Capsicum chinense) seeds

2022

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Capsaicinoids are the main bioactive compounds extracted from chili pepper seeds (CPSs) but other bioactive compounds such as phenolic compounds may be found. Enzyme-assisted extraction (EAE) improves the extraction of bioactive compounds from fruits and seeds. The aim of this study was to establish the cellulase-assisted extraction conditions of capsaicinoids and phenolic compounds from Habanero CPSs (Capsicum chinense) and to evaluate the anti-inflammatory activity of the obtained extracts on murine macrophages. EAE was performed using different temperatures (T1 = 30°C, T2 = 45°C and T3 = 60°C), enzyme concentrations (E1 = 2,500 UI/L and E2 = 250 UI/L), and extraction time periods (0-150 min). Total phenolic compounds were quantified using the Folin-Ciocalteu assay, capsaicin (CAP) and dihydrocapsaicin (DHC) contents were evaluated by HPLC, and anti-inflammatory activity was performed with Griess assay on murine macrophage RAW 264.7 cell culture. The highest phenolic compound content (337.96 mg GAE/L) was achieved at 30°C, 2,500 UI/L, and 150 min of extraction. The highest CAP content (310.23 μg/ml) was obtained at 45°C with 250 UI/L for 150 min, while for DHC (167.72 μg/ml), the conditions were 60°C, 2,500 UI/L, and 120 min. The highest anti-inflammatory response was obtained when 60°C, E2, and 150 min were used for the extraction, and nitric oxide (NO) production was reduced to 22.56%. Based on the results obtained in this research, EAE allowed the recovery of compounds with anti-inflammatory activity from CPS using water as a solvent. There was a correlation between the extraction of CAP and DHC. But although a moderate direct correlation between the concentration of capsaicinoids and total phenolic compounds (TPCs) and an inverse correlation of the presence of the bioactive compounds (TPC, CAP, and DHC) with the NO synthesis, these were not statistically significant. We demonstrated that Habanero seeds are an important raw material to recover anti-inflammatory compounds beyond capsaicinoids using water in EAE.

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Section: Resultsmentioning

confidence: 99%

Enzyme-assisted extraction of anti-inflammatory compounds from habanero chili pepper (Capsicum chinense) seeds

2022

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“…(1) In addition to the extraction techniques mentioned in this paper, modern extraction techniques include pulsed electric field, high voltage discharge, supercritical fluid extraction, high pressure processing and mechanochemical assisted extraction [80] , [81] . These novel techniques can shorten the extraction time and simplify the purification [82] , and should be researched to extract CEP in the future.…”

Section: Discussionmentioning

confidence: 99%

“…(2) From an economic point of view, in recent years, membrane processing (MP) technologies，such as ultra-(UF) and nano-(NF) filtration, has been used to extract polyphenols [83] , capsaicin [80] and anthocyanins [84] , etc. Compared with the traditional extraction technology, MP is a highly selective target solute treatment technology, which has the advantages of simple operation, large-scale feasibility, less operation steps and energy saving.…”

Section: Discussionmentioning

confidence: 99%

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Current status and future challenges in extraction, purification and identification of Cepharanthine (a potential drug against COVID-19)

Wang

Zhou

Wei

et al. 2023

Separation and Purification Technology

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“…Understanding capsaicin research from global perspectives over an extended time is crucial. Although several studies have been published on capsaicin applications, bioactivities, and many other capsaicin-related topics (33)(34)(35), none of these studies explored the scientometric approach to critically assess its progress and current direction in scientific research. Bibliometrics is a valuable tool for evaluating research trends within a subject area, thus providing insight into extensively researched themes and identifying research needs to inform action (36).…”

Section: Introductionmentioning

confidence: 99%

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

et al. 2022

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Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products in the genus Capsicum. Due to its numerous biological effects, there has been extensive and increasing research interest in capsaicin, resulting in increased scientific publications in recent years. Therefore, an in-depth bibliometric analysis of published literature on capsaicin from 2001 to 2021 was performed to assess the global research status, thematic and emerging areas, and potential insights into future research. Furthermore, recent research advances of capsaicin and its combination therapy on human cancer as well as their potential mechanisms of action were described. In the last two decades, research outputs on capsaicin have increased by an estimated 18% per year and were dominated by research articles at 93% of the 3753 assessed literature. In addition, anti-cancer/pharmacokinetics, cytotoxicity, in vivo neurological and pain research studies were the keyword clusters generated and designated as thematic domains for capsaicin research. It was evident that the United States, China, and Japan accounted for about 42% of 3753 publications that met the inclusion criteria. Also, visibly dominant collaboration nodes and networks with most of the other identified countries were established. Assessment of the eligible literature revealed that the potential of capsaicin for mitigating cancer mainly entailed its chemo-preventive effects, which were often linked to its ability to exert multi-biological effects such as anti-mutagenic, antioxidant and anti-inflammatory activities. However, clinical studies were limited, which may be related to some of the inherent challenges associated with capsaicin in the limited clinical trials. This review presents a novel approach to visualizing information about capsaicin research and a comprehensive perspective on the therapeutic significance and applications of capsaicin in the treatment of human cancer.

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Up-to-date strategies and future trends towards the extraction and purification of Capsaicin: A comprehensive review

Cited by 48 publications

References 84 publications

Enzyme-assisted extraction of anti-inflammatory compounds from habanero chili pepper (Capsicum chinense) seeds

Enzyme-assisted extraction of anti-inflammatory compounds from habanero chili pepper (Capsicum chinense) seeds

Current status and future challenges in extraction, purification and identification of Cepharanthine (a potential drug against COVID-19)

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

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