Upconversion Nanoparticles Hybridized Cyanobacterial Cells for Near‐Infrared Mediated Photosynthesis and Enhanced Photodynamic Therapy

Huo, Minfeng; Liu, Peilei; Zhang, Linlin; Wei, Chenyang; Wang, Liying; Chen, Yu; Shi, Jianlin

doi:10.1002/adfm.202010196

Cited by 56 publications

(40 citation statements)

References 28 publications

(17 reference statements)

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“…In addition to CAT, many metal‐based nanoenzymes including Pt (Equation (1)), [ 99,134–135 ] Mn (Equation (2)), [ 111,136–137 ] prussian blue (PB) (Equation (1)), [ 103,138–139 ] and Fe (Equations (3)–(7)) [ 105,108–109,110–141 ] based nanozymes possess CAT‐like catalytic capabilities for tumor reoxygenation. Some of these mechanisms are written below (Equations 1–7)

2 {normalH}_{2} {normalO}_{2} \overset{Pt or PB}{\to} 2 {normalH}_{2} O + {normalO}_{2}

{MnO}_{2} + {normalH}_{2} {normalO}_{2} + 2 {normalH}^{+} \to {Mn}^{2 +} + {normalO}_{2} + 2 {normalH}_{2} O

{Fe}^{2 +} + {normalH}_{2} {normalO}_{2} \to {Fe}^{3 +} +^{•} OH + {OH}^{-}

{Fe}^{3 +} + {normalH}_{2} {normalO}_{2} \to {Fe}^{2 +} + {HO}_{2}^{•} + {normalH}^{+}

{Fe}^{3 +} + {HO}_{2}

…”

Section: In Situ O2 Generationmentioning

confidence: 99%

Conquering the Hypoxia Limitation for Photodynamic Therapy

et al. 2021

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Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due to the hypoxic nature characteristic of many solid tumors, PDT is frequently limited in therapeutic effect. Moreover, the consumption of O2 during PDT may further aggravate the tumor hypoxic condition, which promotes tumor proliferation, metastasis, and invasion resulting in poor prognosis of treatment. Therefore, numerous efforts have been made to increase the O2 content in tumor with the goal of enhancing PDT efficacy. Herein, these strategies developed in past decade are comprehensively reviewed to alleviate tumor hypoxia, including 1) delivering exogenous O2 to tumor directly, 2) generating O2 in situ, 3) reducing tumor cellular O2 consumption by inhibiting respiration, 4) regulating the TME, (e.g., normalizing tumor vasculature or disrupting tumor extracellular matrix), and 5) inhibiting the hypoxia‐inducible factor 1 (HIF‐1) signaling pathway to relieve tumor hypoxia. Additionally, the O2‐independent Type‐I PDT is also discussed as an alternative strategy. By reviewing recent progress, it is hoped that this review will provide innovative perspectives in new nanomaterials designed to combat hypoxia and avoid the associated limitation of PDT.

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2 {normalH}_{2} {normalO}_{2} \overset{Pt or PB}{\to} 2 {normalH}_{2} O + {normalO}_{2}

{MnO}_{2} + {normalH}_{2} {normalO}_{2} + 2 {normalH}^{+} \to {Mn}^{2 +} + {normalO}_{2} + 2 {normalH}_{2} O

{Fe}^{2 +} + {normalH}_{2} {normalO}_{2} \to {Fe}^{3 +} +^{•} OH + {OH}^{-}

{Fe}^{3 +} + {normalH}_{2} {normalO}_{2} \to {Fe}^{2 +} + {HO}_{2}^{•} + {normalH}^{+}

{Fe}^{3 +} + {HO}_{2}

…”

Section: In Situ O2 Generationmentioning

confidence: 99%

Conquering the Hypoxia Limitation for Photodynamic Therapy

et al. 2021

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“…[49][50][51][52][53] Moreover, the core-shell mesoporous structure protect cores from corrosion by acid or oxidation and provide porous shells for cargo loading and impregnation, thus expanding their applications. [54][55][56][57] The assynthesized Fe 3 O 4 @mesoSiO 2 microspheres were soaked in an aqueous solution containing of Y 3+ , Eu 3+ , and VO 4 3À (RE precursor) to introduce the precursor of YVO 4 :Eu 3+ into mesopore channels by virtue of capillary force. Finally, the composite microspheres were thermally treated at 500 C, leading to fluorescent Fe 3 O 4 @mesoSiO 2 @YVO 4 :Eu 3+ microspheres with crystalline YVO 4 :Eu 3+ nanoparticles deposited in the mesopores.…”

Section: Resultsmentioning

confidence: 99%

Versatile core–shell magnetic fluorescent mesoporous microspheres for multilevel latent fingerprints magneto‐optic information recognition

Liu

Xie

et al. 2022

InfoMat

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Latent fingerprints are extremely vital for personal identification and criminal investigation, and potential information recognition techniques have been widely used in the fields of information and communication electronics. Although physical powder dusting methods have been frequently employed to develop latent fingerprints and most of them are carried out by using single component powders of micron‐sized fluorescent particles, magnetic powders, or metal particles, there is still an enormous challenge in producing high‐resolution image of latent fingerprints at different backgrounds or substrates. Herein, a novel and effective nanoimpregnation method is developed to synthesize bifunctional magnetic fluorescent mesoporous microspheres for latent fingerprints visualization by growth of mesoporous silica (mesoSiO2) on magical Fe3O4 core and then deposition of fluorescent YVO4:Eu3+ nanoparticles in the mesopores. The obtained Fe3O4@mesoSiO2@YVO4:Eu3+ microspheres possess spatially isolated magnetic core and fluorescent shell which were insulated by mesoporous silica layer. Due to their small particle size of submicrometer scale, high magnetization and low magnetic remanence as well as the combined magnetic and fluorescent properties, the microspheres show superior performance in visual latent fingerprint recognition with high contrast, high anti‐interference, and sensitivity as well as good retention on multifarious substrates regardless of surface permeability, roughness, refraction, colorfulness, and background fluorescence interference, and it makes them ideal candidates for practical application in fingerprint visualization and even magneto‐optic information storage.

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“…Upon 980 nm NIR light irradiation, UR-Cyan cells showed strong oxygen production and further enhanced subsequent singlet oxygen generation by the photosensitizer, resulting in enhanced and sustainable PDT efficacy against tumor cells/tissues. 74 Compared to cell membranes and other cytoplasmic organelles, the nucleus is highly susceptible to photodynamic damage due to its high sensitivity to PDT. 75 Nucleus-based PDT can cause severe DNA damage and inactivation of intranuclear enzymes.…”

Section: Upconversion-based Photodynamic Therapymentioning

confidence: 99%