Upconversion Nanoprobes: Recent Advances in Sensing Applications

Zhang, Zhiming; Shikha, Swati; Liu, Jinliang; Zhang, Jing; Mei, Qingsong; Zhang, Yong

doi:10.1021/acs.analchem.8b04049

Cited by 214 publications

(122 citation statements)

References 140 publications

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“…Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted a great deal of attention as promising materials for various biomedical applications including medical diagnostics, mainly for in vitro and in vivo imaging, but also in longer perspective for drug and gene delivery, and photothermal and photodynamic therapy of malignancies (Duan et al, 2018;Qin et al, 2019). The particles also find utilization in sensing applications, such as environmental hazard detection, food assays, and biological analysis (Chen et al, 2014;Poláchová et al, 2019;Zhang et al, 2019). Interest in the UCNPs comes from their superior optical properties, such as a narrow line emission, long luminescence lifetime, high photostability, and absence of background fluorescence interference (Wolfbeis, 2015).…”

Section: Introductionmentioning

confidence: 99%

Monodisperse Core-Shell NaYF4:Yb3+/Er3+@NaYF4:Nd3+-PEG-GGGRGDSGGGY-NH2 Nanoparticles Excitable at 808 and 980 nm: Design, Surface Engineering, and Application in Life Sciences

et al. 2020

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4 :Nd 3+-PEG-RGDS nanoparticles on both Hep-G2 and HeLa cells was determined, confirming no adverse effect on their survival and proliferation. The interaction of the nanoparticles with Hep-G2 cells was monitored by confocal microscopy at both 808 and 980 nm excitation. The NaYF 4 :Yb 3+ /Er 3+ @NaYF 4 :Nd 3+-PEG-RGDS nanoparticles were localized on the cell membranes due to specific binding of the RGDS peptide to integrins, in contrast to the NaYF 4 :Yb 3+ /Er 3+ @NaYF 4 :Nd 3+-PEG-Alk particles, which were not engulfed by the cells. The NaYF 4 :Yb 3+ /Er 3+ @NaYF 4 :Nd 3+-PEG-RGDS nanoparticles thus appear to be promising as a new non-invasive probe for specific bioimaging of cells and tissues. This development makes the nanoparticles useful for diagnostic and/or, after immobilization of a bioactive compound, even theranostic applications in the treatment of various fatal diseases.

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Section: Introductionmentioning

confidence: 99%

Monodisperse Core-Shell NaYF4:Yb3+/Er3+@NaYF4:Nd3+-PEG-GGGRGDSGGGY-NH2 Nanoparticles Excitable at 808 and 980 nm: Design, Surface Engineering, and Application in Life Sciences

et al. 2020

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“…Compared to conventional fluorescence nanomaterials (e.g., organic dyes or metal complexes), UCNPs have several advantages, such as high chemical stability, large anti-Stokes shift, narrow emission lines, no blinking, and no bleaching 16 . UCNPs have great potential in a variety of applications, from photovoltaics, photocatalysis, security, and display technology to in vitro and in vivo tissue imaging, background-free biosensors, light-triggered drug and gene delivery, optogenetics, photodynamics and photothermal therapy 17 – 22 . The nanoparticles are also beneficial for multimodal in vivo bioimaging because simple variations of dopant ions in the crystal lattice can induce the formation of particles suitable for down- and upconversion luminescence, MRI, and CT imaging 23 , 24 .…”

Section: Introductionmentioning

confidence: 99%

Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes

Kostiv

Kučka

Lobaz

et al. 2020

Sci Rep

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Abstract“All-in-one” multifunctional nanomaterials, which can be visualized simultaneously by several imaging techniques, are required for the efficient diagnosis and treatment of many serious diseases. This report addresses the design and synthesis of upconversion magnetic NaGdF4:Yb3+/Er3+(Tm3+) nanoparticles by an oleic acid-stabilized high-temperature coprecipitation of lanthanide precursors in octadec-1-ene. The nanoparticles, which emit visible or UV light under near-infrared (NIR) irradiation, were modified by in-house synthesized PEG-neridronate to facilitate their dispersibility and colloidal stability in water and bioanalytically relevant phosphate buffered saline (PBS). The cytotoxicity of the nanoparticles was determined using HeLa cells and human fibroblasts (HF). Subsequently, the particles were modified by Bolton-Hunter-neridronate and radiolabeled by 125I to monitor their biodistribution in mice using single-photon emission computed tomography (SPECT). The upconversion and the paramagnetic properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles were evaluated by photoluminescence, magnetic resonance (MR) relaxometry, and magnetic resonance imaging (MRI) with 1 T and 4.7 T preclinical scanners. MRI data were obtained on phantoms with different particle concentrations and during pilot long-time in vivo observations of a mouse model. The biological and physicochemical properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles make them promising as a trimodal optical/MRI/SPECT bioimaging and theranostic nanoprobe for experimental medicine.

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“…Lanthanide‐doped upconversion nanoparticles (UCNPs) can subsequently absorb two or more near‐infrared (NIR) photons and emit a UV–vis‐NIR photon with higher energy. [ 1 ] Employing NIR photons as excitation source can effectively eliminate auto‐fluorescence from biosamples and confer deeper light penetration and less photodamage, [ 2 ] which makes UCNPs especially suitable for biological applications including bioimaging, biosensing, drug delivery, phototherapy, and so on. [ 3 ] However, due to the parity‐forbidden nature of the 4f‐4f electronic transitions of lanthanide ions, UCNPs suffer from poor light absorption [ 4 ] and accordingly extremely low luminescence efficiency and faint brightness, which impairs their performance in practical applications.…”

Section: Introductionmentioning

confidence: 99%

Removing the Obstacle of Dye‐Sensitized Upconversion Luminescence in Aqueous Phase to Achieve High‐Contrast Deep Imaging In Vivo

Liang

Wang

et al. 2020

Adv Funct Materials

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Although upconversion nanoparticles (UCNPs) have drawn increasing attention for their unique photophysical characteristics, they suffer from a bottleneck of low luminescence efficiency due to the poor absorption coefficient of Ln 3+ . Dye sensitization has provided thousands-fold enhancement of upconversion luminescence (UCL) in organic solvents because of the remarkably improved light absorption ability, but the sensitization of UCL in aqueous phase is only less than 20 folds by far, with unknown restrictive factors. Herein, the aggregation-caused quenching (ACQ) of dyes is revealed as the most important reason limiting dye sensitization in aqueous phase, and the problem is circumvented through delicately modulating the physical properties of dyes and their assembly manner with UCNPs. By further alleviating energy back transfer (EBT) from Ln 3+ to dyes, more than 600-fold enhancement of UCL is achieved in aqueous phase. The as-obtained dyes modified UCNPs show good biocompatibility and high signal contrast when applied for deep in vivo imaging.suitable for biological applications including bioimaging, biosensing, drug delivery, phototherapy, and so on. [3] However, due to the parity-forbidden nature of the 4f-4f electronic transitions of lanthanide ions, UCNPs suffer from poor light absorption [4] and accordingly extremely low luminescence efficiency and faint brightness, which impairs their performance in practical applications.In a pioneering work of 2012, Hummelen et al. put forward a dye-sensitization strategy to improve UCL intensity in organic solvent. Different from direct absorption of the excitation light by lanthanide ions, heptamethine cyanine with a much larger absorption cross section was employed as an antenna to absorb the energy of photons and transferred its excited-state energy to Ln 3+ ions through a resonance energy transfer pathway. [5] Owing to the dramatically enhanced light absorption ability, thousands-fold enhancement of UCL in organic phase has been achieved through the dye-sensitization process. [6] Considering the requirements of biological applications, efforts have also been devoted to the sensitization of UCL in aqueous phase. [7] Unfortunately, the sensitization efficiency in aqueous phase is badly restricted. In the past few years, although various structures and composition of UCNPs have been tried, this embarrassing situation changes very slowly. [8] Up to now, the highest enhancement factor of dye sensitization of UCL reported in aqueous phase was only 17-fold. [7a] This means that in a biological aqueous environment, the dye-sensitization strategy is not yet able to provide a solution to the bottleneck of UCL brightness. More importantly, the key factors restricting dye sensitization in aqueous phase are unclear so far.In this work, by delicately modulating the properties of dyes as well as their assembly manner with UCNPs, we discovered the factors that decide the sensitization efficiency. In previous dye-sensitized UCL systems in aqueous phase, dyes were assembled wi...

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Upconversion Nanoprobes: Recent Advances in Sensing Applications

Cited by 214 publications

References 140 publications

Monodisperse Core-Shell NaYF4:Yb3+/Er3+@NaYF4:Nd3+-PEG-GGGRGDSGGGY-NH2 Nanoparticles Excitable at 808 and 980 nm: Design, Surface Engineering, and Application in Life Sciences

Monodisperse Core-Shell NaYF4:Yb3+/Er3+@NaYF4:Nd3+-PEG-GGGRGDSGGGY-NH2 Nanoparticles Excitable at 808 and 980 nm: Design, Surface Engineering, and Application in Life Sciences

Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes

Removing the Obstacle of Dye‐Sensitized Upconversion Luminescence in Aqueous Phase to Achieve High‐Contrast Deep Imaging In Vivo

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