Upconversion optogenetics-driven biohybrid sensor for infrared sensing and imaging

Yang, Jia; Zu, Lipeng; Li, Gongxin; Zhang, Chuang; Ge, Zhixing; Wang, Wenxue; Wang, Xiaoduo; Liu, Bin; Xi, Ning; Liu, Lianqing

doi:10.1016/j.actbio.2023.01.017

Cited by 4 publications

(4 citation statements)

References 62 publications

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“…[86][87][88] For instance, UCNPs have been used to convert high-penetrating, low-energy near-infrared light into high-energy visible light or fluorescence, which is sufficient to excite voltage-gated channels and generate action potentials. [89][90][91][92] Additionally, photothermal nanoparticles, such as gold nanoparticles (AuNPs), can convert light into heat energy and drive heat-induced promoters to drive downstream signal expression. 93,94 Other nanoparticles, including mechanoluminescent and radioluminescent nanoparticles, have also been widely studied.…”

Section: Light Transmission Problemmentioning

confidence: 99%

“…To address this challenge, researchers have developed several strategies, such as combining nanomaterials with optogenetic structures to enable wireless optogenetics 86–88 . For instance, UCNPs have been used to convert high‐penetrating, low‐energy near‐infrared light into high‐energy visible light or fluorescence, which is sufficient to excite voltage‐gated channels and generate action potentials 89–92 . Additionally, photothermal nanoparticles, such as gold nanoparticles (AuNPs), can convert light into heat energy and drive heat‐induced promoters to drive downstream signal expression 93,94 .…”

Section: Optogenetic Vector Delivery and Optical Fiber Implantationmentioning

confidence: 99%

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Emerging optogenetics technologies in biomedical applications

Ren,

Cheng,

Wen

et al. 2023

Smart Medicine

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Optogenetics is a cutting‐edge technology that merges light control and genetics to achieve targeted control of tissue cells. Compared to traditional methods, optogenetics offers several advantages in terms of time and space precision, accuracy, and reduced damage to the research object. Currently, optogenetics is primarily used in pathway research, drug screening, gene expression regulation, and the stimulation of molecule release to treat various diseases. The selection of light‐sensitive proteins is the most crucial aspect of optogenetic technology; structural changes occur or downstream channels are activated to achieve signal transmission or factor release, allowing efficient and controllable disease treatment. In this review, we examine the extensive research conducted in the field of biomedicine concerning optogenetics, including the selection of light‐sensitive proteins, the study of carriers and delivery devices, and the application of disease treatment. Additionally, we offer critical insights and future implications of optogenetics in the realm of clinical medicine.

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Section: Light Transmission Problemmentioning

confidence: 99%

Section: Optogenetic Vector Delivery and Optical Fiber Implantationmentioning

confidence: 99%

Emerging optogenetics technologies in biomedical applications

Ren,

Cheng,

Wen

et al. 2023

Smart Medicine

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“…Rare earth (RE) ions co-doped upconversion (UC) materials have the ability to convert infrared light into visible light, making them attractive for many applications, such as solid-state lasers [1], waveguide amplifiers [2], display devices [3], solar cells [4], biological imaging [5], biological sensing [6], detectors [7], and temperature sensors [8]. To obtain an efficient UC process, it is necessary to use a host matrix with low phonon energy and an optimized co-dopant concentration to avoid non-radiative transitions [9,10].…”

Section: Introductionmentioning

confidence: 99%

Efficient green upconversion emission in transparent Teo2-Geo2 glass-ceramic obtained by billet extrusion

Leśniak,

Jiménez,

Starzyk

et al. 2024

Metrology and Measurement Systems

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Transparent Yb3+/Er3+glass-ceramic was successfully obtained by the extrusion method. The extrusion of oxyfluoride tellurite-germanate glass co-doped with Yb3+and Er3+ions at 520°C resulted in the formation of Ba0:75Er0:25F2:25 nanocrystals, leading to an increase in the upconversion (UC) emission intensity of 35 times in glass-ceramic with respect to the glass. The glass to glass-ceramic transition was confirmed by X-ray diffraction (XRD) and Transmission electron microscope (TEM). Also, the structural changes that occurred during crystallization were assessed using Fourier-transform infrared (FTIR) spectroscopy. Furthermore, the pump power and temperature UC emission dependence of glass and glass-ceramic under 976 nm laser excitation were investigated in detail. The assessments showed that i) two-phonons are involved in the UC process and ii) the temperature has a significant influence over it. The Yb3+/Er3+ codoped glass-ceramic shows relatively high Sa and Sr values in a wide temperature range from 300 to 573 K, presenting the maximal Sa value of 3:50 x 10–3 at 573 K and the maximal Sr value of 6:30 x 10–3at 364 K. These results suggest that the glass-ceramic is a good candidate for optical applications such as luminescent thermometry.

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“…This is because the biological unit in biohybrid sensors can sense and respond to a wider range of weak physiological stimuli with higher specificity [6] and can integrate with the host through vascularization to create a more physiological connection to the external evaluation units. Recent in vitro studies have shown the potential of biohybrid sensors for applications such as odorant [7] and taste [8] sensing, directional chemical source detection, [9] infrared detection, [10] and drug evaluation. [11,12] However, to extend these applications to in vivo microenvironments, new strategies are needed that can meet the requirements of the host tissue, the biological sensing, and the nonbiological readout units.…”

Section: Introductionmentioning

confidence: 99%

3D‐Printed Biohybrid Microstructures Enable Transplantation and Vascularization of Microtissues in the Anterior Chamber of the Eye

Kavand,

Visa,

Köhler

et al. 2023

Advanced Materials

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Hybridizing biological cells with man‐made sensors enable the detection of a wide range of weak physiological responses with high specificity. The anterior chamber of the eye (ACE) is an ideal transplantation site due to its ocular immune privilege and optical transparency, which enable superior noninvasive longitudinal analyses of cells and microtissues. Engraftment of biohybrid microstructures in the ACE may, however, be affected by the pupillary response and dynamics. Here, sutureless transplantation of biohybrid microstructures, 3D printed in IP‐Visio photoresin, containing a precisely localized pancreatic islet to the ACE of mice is presented. The biohybrid microstructures allow mechanical fixation in the ACE, independent of iris dynamics. After transplantation, islets in the microstructures successfully sustain their functionality for over 20 weeks and become vascularized despite physical separation from the vessel source (iris) and immersion in a low‐viscous liquid (aqueous humor) with continuous circulation and clearance. This approach opens new perspectives in biohybrid microtissue transplantation in the ACE, advancing monitoring of microtissue–host interactions, disease modeling, treatment outcomes, and vascularization in engineered tissues.

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Upconversion optogenetics-driven biohybrid sensor for infrared sensing and imaging

Cited by 4 publications

References 62 publications

Emerging optogenetics technologies in biomedical applications

Emerging optogenetics technologies in biomedical applications

Efficient green upconversion emission in transparent Teo2-Geo2 glass-ceramic obtained by billet extrusion

3D‐Printed Biohybrid Microstructures Enable Transplantation and Vascularization of Microtissues in the Anterior Chamber of the Eye

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