Update about Oralair® as a treatment for grass pollen allergic rhinitis

Klimek, Ludger; Mösges, R.; Demoly, Pascal; Mullol, Joaquim; Wang, De Yun; O’Hehir, Robyn E; Didier, A.; Kopp, Matthias; Bos, Catherine; Karagiannis, E.

doi:10.1080/21645515.2022.2066424

Cited by 2 publications

(1 citation statement)

References 87 publications

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“…Notably in 2019, the number of participants reporting moderate/severe allergic rhinitis symptoms in the control group increased compared with 2018 baseline, whereas no such increase was noted in the Oralair treatment group after the first year of treatment. This is in line with current literature that shows Oralair desensitisation immunotherapy to be an effective and well tolerated treatment for grass pollen allergic rhinitis [ 9 10 ]. Another factor may have been that outcome assessment for allergic rhinitis in this study was the ARIA severity score.…”

Section: Discussionsupporting

confidence: 91%

The Melbourne epidemic thunderstorm asthma event 2016: a 5-year longitudinal study

Huang

Wang

Foo

et al. 2022

Asia Pacific Allergy

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Background In 2016, Melbourne was struck by the world’s largest and most devastating epidemic thunderstorm asthma (ETSA) episode. While affected individuals displayed worsened short-term asthma control, little is known about their longer-term natural history, nor about interventions that restore control. Objective We assessed the asthma symptomatology and related behaviours of ETSA-affected individuals through a single-centre prospective 5-year longitudinal study. We embedded an open-label observational trial investigating the role of grass pollen sublingual tablet (Oralair) allergen immunotherapy in improving asthma and allergic rhinitis symptoms. Methods Allergic rhinitis symptom severity, frequency of asthma symptoms and inhaled corticosteroid usage were assessed via questionnaire yearly. In 2018, a subgroup of participants was enrolled in an observational study of Oralair treatment compared to control. The active group received Oralair from 2019 to 2021; both groups were followed-up for 5 years. Subgroup analyses were performed for participants with complete datasets, and who completed the trial per-protocol. Results Year-on-year data across 5 years was available for 30 participants. The rate of persistent asthma symptoms declined from 37% to 7% in 2016 to 2021. Only 10%–27% of participants reported being completely asymptomatic in any given year. The inhaled preventer prescription rate was 67%, with only 35% being adherent. Twenty-seven participants with available data completed the Oralair trial per-protocol. No significant difference was noted between control and active groups for allergic rhinitis symptoms or asthma control, although the Oralair group saw a significant improvement in asthma control comparing 2019 with 2021. Conclusion This is the longest documented follow-up of ETSA-affected individuals. Five years following sentinel event, there was progressive reduction but some persistence in asthma symptoms. Oralair allergen immunotherapy did not further improve allergic rhinitis or asthma symptoms compared to control, but there were no further ETSA events to test a protective effect during the study period.

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Section: Discussionsupporting

confidence: 91%

The Melbourne epidemic thunderstorm asthma event 2016: a 5-year longitudinal study

Huang

Wang

Foo

et al. 2022

Asia Pacific Allergy

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Trends in airborne grass pollen in Évora City (Portugal)

Caeiro,

Camacho,

Ferreira

et al. 2024

Aerobiologia

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Aerobiology could be used as complementary data or proxy for studying phenology, especially in species which usually are not long-distance transported, such as grasses. This 21-year aerobiological study took place in Évora (South Portugal), using a seven-day recording volumetric pollen trap with the aim of analysing the temporal trends of grass pollen seasons. To this end, data were statistically tested for correlation and regression to determine the features and temporal trends of pollen seasons. Main results show that Poaceae pollen has a high representation in pollen spectrum, 20% (min: 7%; max: 44%), with a long season starting in March and lasting till August/September or October. There was an overall, but not statistically significant trend, towards an increase in the annual pollen integral and peak values, and also an overall non-statistically significant trend towards an earlier start and later end of the pollen season. Main and high pollen seasons have been lasting longer, and the days with allergenic potential have been rising in line with the local temperature rising trend. It seems that grass pollen production is being aided by warmer temperatures and increased grassland areas in Alentejo region. This could promote the increase in annual pollen levels and in the number of high pollen days over the years. In clinical terms, it means that grass allergic patients are exposed to longer periods of airborne pollen and to higher counts over a longer time. The climate conditions projected for Alentejo region, including rising temperature, and the changes in local grassland areas may help to clarify the trends of grass pollen seasons in the next decades.

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Update about Oralair® as a treatment for grass pollen allergic rhinitis

Cited by 2 publications

References 87 publications

The Melbourne epidemic thunderstorm asthma event 2016: a 5-year longitudinal study

The Melbourne epidemic thunderstorm asthma event 2016: a 5-year longitudinal study

Trends in airborne grass pollen in Évora City (Portugal)

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