Update and insights into treatment options for chronic spontaneous urticaria

Abstract

Chronic spontaneous urticaria (CSU) is defined as itchy weals, angio-oedema, or both, arising spontaneously without external physical stimuli. Symptoms of the disease continue to develop for more than 6 weeks. It carries a high socioeconomic burden with considerable health care costs. Second generation H1-antihistamines are the mainstay of urticaria treatment and are the only licensed option. However, many patients are resistant to H1-antihistamine therapy. Omalizumab has proven to be an effective therapeutic option in patients with recalcitrant chronic urticaria. Ciclosporin appears to be more beneficial in patients with functional histamine releasing autoantibodies as a cause of their disease. This review article will highlight the major therapeutic options available today for the management of CSU knowing that good quality evidence for efficacy of many agents is scarce except for H1-antihistamines and omalizumab.

Investigation of Patient-Specific Characteristics Associated with Treatment Outcomes for Chronic Urticaria

“…3 These costs are even more significant when one considers that the treatment of CU may be required over many years. 9 CU remains a therapeutic challenge for physicians, because there are no well-structured clinically effective treatment Abbreviations used CU-Chronic urticaria JTFPP-Joint Task Force Practice Parameter LTRA-Leukotriene receptor antagonist OR-Odds ratio algorithm(s) available, based on the presence or absence of specific patient characteristics. 1,10,11 Although the most recent Joint Task Force Practice Parameter (JTFPP) for CU recommends an algorithmic approach (step 1-4) for the treatment of CU, it does not link the step care approach to objective patient-specific characteristics (physical, serologic, or histologic traits).…”

Kroni̇k Ürti̇kerli̇ Hastalarda Basamak Tedavi̇si̇ne Yanit Ve Prognosti̇k Faktörler: Retrospekti̇f Çalişma

“…Her soruda bulunan 5 cevap 0-4 arası puanlandırıldı. Toplam 12 puan alan hastanın klinik kontrolü iyi olarak kabul edildi 3,9,10 .…”