Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What Is New in the 2017 WHO Blue Book for Tumors and Tumor-Like Lesions of the Neck and Lymph Nodes

Katabi, Nora; Lewis, James S.

doi:10.1007/s12105-017-0796-z

Cited by 44 publications

(34 citation statements)

References 53 publications

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“…In addition, both cysts were detected in individuals with mean age close to 35 years old (37.2 ± 28.6 and 38.2 ± 22.9, respectively). However, it is important to point out that these lesions can be diagnosed in a wide age group, with reports as distinct as in 7-month and 77-year-old individuals (9). The clinical presentation of these lesions in the oral cavity depends on their size, which can vary between 1 and 5 cm, as well as their anatomical location (16).…”

Section: Resultsmentioning

confidence: 99%

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Dermoid and epidermoid cysts of the oral cavity: a 48-year retrospective study with focus on clinical and morphological features and review of main topics

Santos

Rolim²,

Barros

et al. 2020

Med Oral

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Background: Dermoid and epidermoid cysts are slow-growing, benign developmental cysts that arise from ectodermal tissue and can occur anywhere in the body. Less than 7% of these cysts involve the head and neck region, with only 1.6% of cases presenting in the oral cavity. To evaluate the clinical and histopathological features of dermoid (DCs) and epidermoid (ECs) cysts stored in the archives of a referred Oral Pathology Service over a 48-year-period, and to review current concepts about these cysts. Material and Methods: All DCs and ECs were reviewed, and clinical data were obtained from the patient records. Fourteen cases of DCs and thirteen cases of ECs were re-evaluated microscopically by 2 oral pathologists. Results: Among 15.387 cases, 14 (0.09%) had a histopathological diagnosis of DCs and 13 (0.08%) of ECs. For DCs, ten (71.4%) patients were women, with the mean age of 37.2 years. All DCs were lined by a stratified squamous epithelium (100%), with gut and respiratory epithelium observed in 1 (7.1%) and 2 (14.3%) cases, respectively. Chronic inflammatory cells, melanin, multinucleated giant cell reaction, and Pacini bodies were also observed. For ECs, eight (61.5%) cases were in women, and the mean age was 38.2 years. All ECs were lined by a stratified squamous epithelium (100%). Chronic inflammatory cells, melanin pigmentation, and adipose tissue were observed in the fibrous capsule.

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Section: Resultsmentioning

confidence: 99%

“…DCs and ECs are uncommon lesions in the head and neck region, corresponding to 7% of all cases, presenting even less frequently in the oral cavity, representing between only 0.01% and 1.6% of all oral cysts (3,4,(9)(10)(11). Yilmaz et al (11) report that ECs are more common when compared to DCs.…”

Section: Discussionmentioning

confidence: 99%

Dermoid and epidermoid cysts of the oral cavity: a 48-year retrospective study with focus on clinical and morphological features and review of main topics

Santos

Rolim²,

Barros

et al. 2020

Med Oral

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“…All samples were confirmed by pathological examination. The histological grade and tumor stage were assigned according to the World Health Organization (WHO) (16) and the International Union Against Cancer classification system (17).…”

Section: Methodsmentioning

confidence: 99%

Adenovirus‑mediated overexpression of interleukin‑21 regulates the development of oral squamous cell carcinoma in vitro

Liu

Sun

et al. 2020

Oncol Lett

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Interleukin-21 (IL-21) is an important cytokine that is currently being investigated for its potential use in tumor immunotherapy in the future. In tumor cells, IL-21 stimulates the immune response by increasing the cytotoxic activity of natural killer cells, B cells and CD8 + T cells, which in turn induces the apoptosis of tumor cells. The therapeutic effects of IL-21 have been investigated in several types of disease and numerous clinical trials are in progress. The aim of the present study was to determine the role of IL-21 in oral squamous cell carcinoma (OSCC) in vitro. IL-21 expression was detected in OSCC tissues via RT-qPCR, western blotting and immunohistochemistry analyses. The results demonstrated that IL-21 protein expression decreased in OSCC tissues. IL-21 was overexpressed using adenovirus in CAL-27 cells. The Cell Counting Kit-8 assay demonstrated that overexpression of IL-21 inhibited cell proliferation. Furthermore, overexpression of IL-21 inhibited cell migration, detected by the wound healing assay, and promoted cell apoptosis, detected by TUNEL staining and flow cytometry analysis. The results demonstrated that overexpression of IL-21 inhibited activation of the JNK signaling pathway. In conclusion, the findings of the present study suggest that IL-21 may function as a potent antitumor agent in OSCC.

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“…With increasing molecular testing of tumors, unique subsets of sinonasal tumors, as with other malignancies, have been described by their unique molecular alterations . This was reflected in the most recent World Health Organization histological classification of the tumors of the nasal cavity and paranasal sinuses which now includes the following key subtypes: squamous cell carcinoma, intestinal‐type adenocarcinoma, nonintestinal sinonasal adenocarcinoma, NUT midline carcinoma, biphenotypic sinonasal sarcoma, human papillomavirus (HPV)‐related carcinoma with adenoid cystic features, SMARCB1 (INI‐1)–deficient sinonasal carcinoma, renal cell‐like adenocarcinoma, sinonasal lymphoepithelial carcinoma, and SNUC.…”

Section: Introductionmentioning

confidence: 99%

INI-1 (SMARCB1)–Deficient Undifferentiated Sinonasal Carcinoma: Novel Paradigm of Molecular Testing in the Diagnosis and Management of Sinonasal Malignancies

et al. 2020

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Sinonasal tumors consist of a group of rare heterogeneous malignancies, accounting for 3%-5% of all head and neck cancers. Although squamous cell carcinomas make up a significant portion of cancers arising in the sinonasal tract, there are a variety of aggressive tumor types that can present with a poorly differentiated morphology and continue to pose diagnostic challenges. Accurate classification of these unique malignancies has treatment implications for patients. Recent discoveries have allowed more detailed molecular characterization of subsets of these tumor types, and may lead to individualized treatments. INI-1 (SMARCB1)-deficient sinonasal

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Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What Is New in the 2017 WHO Blue Book for Tumors and Tumor-Like Lesions of the Neck and Lymph Nodes

Abstract: corrections of these neck lesions in order to correctly diagnosis them and to provide for proper clinical management. This article will briefly describe the pathologic and clinical features of these entities as they are covered in the new 2017 Blue Book.

Cited by 44 publications

References 53 publications

Dermoid and epidermoid cysts of the oral cavity: a 48-year retrospective study with focus on clinical and morphological features and review of main topics

Dermoid and epidermoid cysts of the oral cavity: a 48-year retrospective study with focus on clinical and morphological features and review of main topics

Adenovirus‑mediated overexpression of interleukin‑21 regulates the development of oral squamous cell carcinoma in vitro

INI-1 (SMARCB1)–Deficient Undifferentiated Sinonasal Carcinoma: Novel Paradigm of Molecular Testing in the Diagnosis and Management of Sinonasal Malignancies

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