Update in Chronic Obstructive Pulmonary Disease 2020

Ritchie, A.; Baker, J.R.; Parekh, Trisha M; Allinson, James P.; Bhatt, Surya P.; Donnelly, Louise; Donaldson, Gavin C.

doi:10.1164/rccm.202102-0253up

Cited by 12 publications

(7 citation statements)

References 97 publications

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“…Moreover, the prevalence of COPD was 21% in all subjects, which is in good accordance with previous reports (14.6% to 41%) of patients with NAFLD [41,42]. In addition, aging and long-term smoking were risk factors for COPD in previous studies [9], and our study showed the same trend that median age, smoking rate, and heavy smoking were all higher in the COPD group than in the non-COPD group. Thus, our database appears to correspond with the general characteristics of the population in Japan.…”

Section: Discussionsupporting

confidence: 92%

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MAFLD associated with COPD via systemic inflammation independent of aging and smoking in men

Tsutsumi

Nakano

Kawaguchi

et al. 2022

Diabetol Metab Syndr

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Background and aim Metabolic dysfunction and associated systemic inflammation are risk factors for chronic obstructive pulmonary disease (COPD) and COPD is highly prevalent in men. We investigated the impact of metabolic-associated fatty liver disease (MAFLD) and MAFLD-related systemic inflammation on COPD in men. Methods We enrolled 2,041 men with fatty liver. Patients were classified into the COPD (n = 420/2041) and non-COPD (n = 1621/2041) groups. COPD and its high-risk group were diagnosed using the Japanese Respiratory Society Disease statement. Systemic inflammation was evaluated using the C-reactive protein (CRP)/albumin ratio. Independent factors for COPD were investigated by multivariate analysis and decision-tree analysis. Results The prevalence of MAFLD was significantly higher in the COPD group than in the non-COPD group. In multivariable analysis, in addition to heavy smoking and aging, MAFLD was identified as an independent factor for COPD (OR 1.46, 95% CI 1.020–2.101, P = 0.0385). Decision-tree analysis showed that MAFLD, rather than heavy smoking, was the most influential classifier for COPD in non-elderly men (14% in MAFLD vs 6% in non-MAFLD groups). MAFLD was also the second most influential factor in elderly men who were not heavy smokers. In both groups, the CRP/albumin ratio was the first classifier for COPD (16% in the high CRP/albumin ratio group vs 3% in the low CRP/albumin ratio group of non-elderly men). Conclusions MAFLD is an independent predictor of COPD in men. MAFLD had a significant impact on COPD through systemic inflammation in men of all ages who were not heavy smokers. MAFLD may be useful to broadly identify COPD in men.

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Section: Discussionsupporting

confidence: 92%

“…NAFLD is also associated with the severity of COPD, and the risk of COPD is particularly high in adult men [ 8 ]. Smoking and aging are well-established risk factors for COPD [ 9 ]. However, one-fourth of adults with COPD have never smoked, indicating the presence of other risk factors [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

MAFLD associated with COPD via systemic inflammation independent of aging and smoking in men

Tsutsumi

Nakano

Kawaguchi

et al. 2022

Diabetol Metab Syndr

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“…[270] The development and exacerbation of CRDs are greatly influenced by environmental contaminant exposures, specifically air pollution. [271][272][273] The pathogenesis of CRDs exhibits a diverse spectrum of manifestation including oxidative stress, autophagy, mitochondrial dysfunction, formation of fibrosis and/or emphysema, and significant alterations in the ECM, affecting mechanical support and biochemical cell signals. [274][275][276] Treatments currently available can only help temporarily alleviate discomfort, while the only long term therapeutic solution currently consists of highly invasive organ transplants.…”

Section: Treating Other Chronic Diseases With Hydrogels and Hydrogel ...mentioning

confidence: 99%

Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare through Human and Environmental Treatment

Gutiérrez

Frazar

Klaus

et al. 2021

Adv Healthcare Materials

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Humans are constantly exposed to exogenous chemicals throughout their life, which can lead to a multitude of negative health impacts. Advanced materials can play a key role in preventing or mitigating these impacts through a wide variety of applications. The tunable properties of hydrogels and hydrogel nanocomposites (e.g., swelling behavior, biocompatibility, stimuli responsiveness, functionality, etc.) have deemed them ideal platforms for removal of environmental contaminants, detoxification, and reduction of body burden from exogenous chemical exposures for prevention of disease initiation, and advanced treatment of chronic diseases, including cancer, diabetes, and cardiovascular disease. In this review, three main junctures where the use of hydrogel and hydrogel nanocomposite materials can intervene to positively impact human health are highlighted: 1) preventing exposures to environmental contaminants, 2) prophylactic treatments to prevent chronic disease initiation, and 3) treating chronic diseases after they have developed.

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“…COPD is a global health epidemic predominantly caused by cigarette smoke (CS), and it is responsible for more than 3 million deaths worldwide every year and the third leading cause of death in the world. In addition, it is also a leading cause of chronic morbidity [ 2 ]. Pulmonary architectural disruption induced by chronic airway inflammation triggered by CS is arguably one of the most intractable problems of COPD, resulting in irreversible loss of lung function [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Exosomes derived from adipose-derived stem cells alleviate cigarette smoke-induced lung inflammation and injury by inhibiting alveolar macrophages pyroptosis

Zhu

Lian

et al. 2022

Respir Res

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Background Chronic obstructive pulmonary disease (COPD) is a frequently encountered disease condition in clinical practice mainly caused by cigarette smoke (CS). The aim of this study was to investigate the protective roles of human adipose-derived stem cells-derived exosomes (ADSCs-Exo) in CS-induced lung inflammation and injury and explore the underlying mechanism by discovering the effects of ADSCs-Exo on alveolar macrophages (AMs) pyroptosis. Methods ADSCs were isolated from human adipose tissues harvested from three healthy donors, and then ADSCs-Exo were isolated. In vivo, 24 age-matched male C57BL/6 mice were exposed to CS for 4 weeks, followed by intratracheal administration of ADSCs-Exo or phosphate buffered saline. In vitro, MH-S cells, derived from mouse AMs, were stimulated by 2% CS extract (CSE) for 24 h, followed by the treatment of ADSCs-Exo or phosphate buffered saline. Pulmonary inflammation was analyzed by detecting pro-inflammatory cells and mediators in the bronchoalveolar lavage fluid. Lung histology was assessed by hematoxylin and eosin staining. Mucus production was determined by Alcian blue-periodic acid-Schiff staining. The profile of AMs pyroptosis was evaluated by detecting the levels of pyroptosis-indicated proteins. The inflammatory response in AMs and the phagocytic activity of AMs were also investigated. Results In mice exposed to CS, the levels of pro-inflammatory cells and mediators were significantly increased, mucus production was markedly increased and lung architecture was obviously disrupted. AMs pyroptosis was elevated and AMs phagocytosis was inhibited. However, the administration of ADSCs-Exo greatly reversed these alterations caused by CS exposure. Consistently, in MH-S cells with CSE-induced properties modelling those found in COPD, the cellular inflammatory response was elevated, the pyroptotic activity was upregulated while the phagocytosis was decreased. Nonetheless, these abnormalities were remarkably alleviated by the treatment of ADSCs-Exo. Conclusions ADSCs-Exo effectively attenuate CS-induced airway mucus overproduction, lung inflammation and injury by inhibiting AMs pyroptosis. Therefore, hADSCs-Exo may be a promising cell-free therapeutic candidate for CS-induced lung inflammation and injury.

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Update in Chronic Obstructive Pulmonary Disease 2020

Cited by 12 publications

References 97 publications

MAFLD associated with COPD via systemic inflammation independent of aging and smoking in men

MAFLD associated with COPD via systemic inflammation independent of aging and smoking in men

Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare through Human and Environmental Treatment

Exosomes derived from adipose-derived stem cells alleviate cigarette smoke-induced lung inflammation and injury by inhibiting alveolar macrophages pyroptosis

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