Update in Pulmonary Infections 2010

Wunderink, Richard G.; Waterer, Grant

doi:10.1164/rccm.201103-0381up

Cited by 3 publications

(4 citation statements)

References 43 publications

(32 reference statements)

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“…(30) Querol-Ribelles et al examined the relationship between d-dimer levels and outcome in a prospective observational study with CAP patients. (26) In nonsurvivors, the mean d-dimer plasma level was 3.786 ng/ml, while in survivors, the mean level was 1.609 ng/ml (p<0.0001). A significant association was found between the presence of elevated d-dimer levels and PSI and APACHE II scores.…”

Section: D-dimer and Coagulation Parametersmentioning

confidence: 85%

“…A significant association was found between the presence of elevated d-dimer levels and PSI and APACHE II scores. (26) Milbrandt et al observed in a recent large cohort study that coagulation abnormalities frequently occurred in patients with CAP requiring hospitalization, and d-dimer levels were again correlated with disease severity and survival. (31) Recently, Salluh et al prospectively evaluated the frequency of early coagulation abnormalities and their impact on outcome in 90 patients with severe CAP requiring ICU admission.…”

Section: D-dimer and Coagulation Parametersmentioning

confidence: 97%

“…(24) Nonetheless, the recent CAPTIVATE trial did not show any survival benefits for this treatment; however, no biomarkerbased stratification was applied. (26) Several coagulation markers have been evaluated in severe CAP. One of the most studied, d-dimer, results from the fibrin breakdown after fibrinolytic system activation.…”

Section: D-dimer and Coagulation Parametersmentioning

confidence: 99%

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Novos marcadores biológicos na pneumonia comunitária grave

Rabello¹,

Pitrowsky²,

Soares³

et al. 2011

Rev. bras. ter. intensiva

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Community-acquired pneumonia (CAP) is the most common infectious disease requiring admission to intensive care units (ICUs), and achieving an early and precise diagnosis of CAP remains a challenge. Biomarkers play an important role in improving clinical judgment in the emergency room and are adjuvant in evaluating treatment responses. Novel biomarkers, such as cortisol, pro-adrenomedullin and endothelin-1, have been shown to be associated with disease severity and short-term outcomes. This review article focuses on the clinical use of novel biomarkers, severity prediction and treatment monitoring as well as future directions of the field.

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Section: D-dimer and Coagulation Parametersmentioning

confidence: 85%

Section: D-dimer and Coagulation Parametersmentioning

confidence: 97%

Section: D-dimer and Coagulation Parametersmentioning

confidence: 99%

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Novos marcadores biológicos na pneumonia comunitária grave

Rabello¹,

Pitrowsky²,

Soares³

et al. 2011

Rev. bras. ter. intensiva

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“…In addition, pneumonia is the most common source of severe sepsis. The estimated financial cost of treating pneumonia in the USA alone exceeds 12 billion dollars per year [2] .…”

Section: Introductionmentioning

confidence: 99%

Lack of Association of the Caspase-12 Long Allele with Community-Acquired Pneumonia in People of African Descent

Chen

Wilson²,

Dahmer

et al. 2014

PLoS ONE

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Community-acquired pneumonia (CAP) is a common cause of sepsis. Active full-length caspase-12 (CASP12L), confined to the people of African descent, has been associated with increased susceptibility to and mortality from severe sepsis. The objective of this study was to determine whether CASP12L was a marker for susceptibility and/or severity of CAP. We examined three CAP cohorts and two control populations: 241 adult Memphis African American CAP patients, 443 pediatric African American CAP patients, 90 adult South African CAP patients, 120 Memphis healthy adult African American controls and 405 adult Chicago African American controls. Clinical outcomes including mortality, acute respiratory distress syndrome (ARDS), septic shock or severe sepsis, need for mechanical ventilation, and S. pneumoniae bacteremia. Neither in the three individual CAP cohorts nor in the combined CAP cohorts, was mortality in CASP12L carriers significantly different from that in non-CASP12L carriers. No statistically significant association between genotype and any measures of CAP severity was found in any cohort. We conclude that the functional CASP12L allele is not a marker for susceptibility and/or severity of CAP.

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Assessment of thoracic ultrasound in complementary diagnosis and in follow up of community-acquired pneumonia (cap)

et al. 2017

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BackgroundChest X-ray (CXR) is the primary diagnostic tool for community-acquired pneumonia (CAP). Some authors recently proposed that thoracic ultrasound (TUS) could valuably flank or even reliably substitute CXR in the diagnosis and follow-up of CAP. We investigated the clinical utility of TUS in a large sample of patients with CAP, to challenge the hypothesis that it may be a substitute for CXR.MethodsOut of 645 consecutive patients with a CXR-confirmed CAP diagnosed in the emergency room of our hospital over a three-years period, 510 were subsequently admitted to our department of Internal Medicine. These patients were evaluated by TUS by a well-trained operator who was blinded of the initial diagnosis. TUS scans were performed both at admission and repeated at day 4-6th and 9-14th during stay.ResultsTUS identified 375/510 (73.5%) of CXR-confirmed lesions, mostly located in posterior-basal or mid-thoracic areas of the lungs. Pleural effusion was detected in 26.9% of patients by CXR and in 30.4% by TUS. TUS documented the change in size of the consolidated areas as follows: 6.3 ± 3.4 cm at time 0, 2.5 ± 1.8 at 4-6 d, 0.9 ± 1.4 at 9-14 d. Out of the 12 patients with delayed CAP healing, 7 of them turned out to have lung cancer.ConclusionsTUS allowed to detect lung consolidations in over 70% of patients with CXR-confirmed CAP, but it gave false negative results in 26.5% of cases. Our longitudinal results confirm the role of TUS in the follow-up of detectable lesions. Thus, TUS should be regarded as a complementary and monitoring tool in pneumonia, instead of a primary imaging modality.

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Update in Pulmonary Infections 2010

Cited by 3 publications

References 43 publications

Novos marcadores biológicos na pneumonia comunitária grave

Novos marcadores biológicos na pneumonia comunitária grave

Lack of Association of the Caspase-12 Long Allele with Community-Acquired Pneumonia in People of African Descent

Assessment of thoracic ultrasound in complementary diagnosis and in follow up of community-acquired pneumonia (cap)

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