Update in Sleep Medicine 2014

Ayas, Najib; Owens, Robert L.; Gozal, David

doi:10.1164/rccm.201503-0647up

Cited by 31 publications

(17 citation statements)

References 45 publications

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“…Obstructive sleep apnea (OSA) is increasingly recognized as a complex and heterogeneous disorder [1]. Recent work shows that this heterogeneity exists in the domains of the presenting symptoms [2], physiologic etiology [3], comorbid conditions [4], and important outcomes [5-7].…”

Section: Introductionmentioning

confidence: 99%

Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches

Zinchuk

Gentry

Concato

et al. 2017

Sleep Medicine Reviews

249

153

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Summmary Obstructive sleep apnea (OSA) is a complex and heterogeneous disorder and the apnea hypopnea index alone can not capture the diverse spectrum of the condition. Enhanced phenotyping can improve prognostication, patient selection for clinical trials, understanding of mechanisms, and personalized treatments. In OSA, multiple condition characteristics have been termed “phenotypes.” To help classify patients into relevant prognostic and therapeutic categories, an OSA phenotype can be operationally defined as: “A category of patients with OSA distinguished from others by a single or combination of disease features, in relation to clinically meaningful attributes (symptoms, response to therapy, health outcomes, quality of life).” We review approaches to clinical phenotyping in OSA, citing examples of increasing analytic complexity. Although clinical feature based OSA phenotypes with significant prognostic and treatment implications have been identified (e.g., excessive daytime sleepiness OSA), many current categorizations lack association with meaningful outcomes. Recent work focused on pathophysiologic risk factors for OSA (e.g., arousal threshold, craniofacial morphology, chemoreflex sensitivity) appears to capture heterogeneity in OSA, but requires clinical validation. Lastly, we discuss the use of machine learning as a promising phenotyping strategy that can integrate multiple types of data (genomic, molecular, cellular, clinical) to identify unique, meaningful OSA phenotypes.

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Section: Introductionmentioning

confidence: 99%

Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches

Zinchuk

Gentry

Concato

et al. 2017

Sleep Medicine Reviews

249

153

View full text Add to dashboard Cite

show abstract

“…(5) If TCES is used as a stand-alone treatment, what is the long-term impact on sleep, sleep disordered breathing, patient symptoms (ie, snoring, sleepiness and quality of life), patient acceptance/adherence and long-term cardiovascular/metabolic risk? 1617 …”

mentioning

confidence: 99%

Stimulating therapy for obstructive sleep apnoea

Strollo

Malhotra

2016

Thorax

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“…The pathogenesis and treatment of sleep disorders in children are generally well understood; however, the optimal treatment of obstructive sleep apnoea (OSA) and the potential impact of comorbidities is less certain [53, 54]. D omany et al [55] examined the rate of treatment failure in 659 children with moderate-to-severe OSA.…”

Section: Sleep Monitoringmentioning

confidence: 99%

Key paediatric messages from Amsterdam

Grigg

Barben²,

Bohlin

et al. 2016

ERJ Open Res

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The Paediatric Assembly of the European Respiratory Society (ERS) maintained its high profile at the 2015 ERS International Congress in Amsterdam. There were symposia on preschool wheeze, respiratory sounds and cystic fibrosis; an educational skills workshop on paediatric respiratory resuscitation; a hot topic session on risk factors and early origins of respiratory diseases; a meet the expert session on paediatric lung function test reference values; and the annual paediatric grand round. In this report the Chairs of the Paediatric Assembly's Groups highlight the key messages from the abstracts presented at the Congress.

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Update in Sleep Medicine 2014

Cited by 31 publications

References 45 publications

Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches

Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches

Stimulating therapy for obstructive sleep apnoea

Key paediatric messages from Amsterdam

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